A5046619289- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Traumatic Brain Injury and Neurovascular Disturbances
- Pituitary Gland Disorders and Treatments
- RNA Interference and Gene Delivery
- Protein Tyrosine Phosphatases
- Connective tissue disorders research
- CAR-T cell therapy research
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Congenital Heart Disease Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Biomedical Text Mining and Ontologies
- Tuberous Sclerosis Complex Research
- Neurosurgical Procedures and Complications
- S100 Proteins and Annexins
- Nanowire Synthesis and Applications
- Data Mining Algorithms and Applications
- Scoliosis diagnosis and treatment
- IgG4-Related and Inflammatory Diseases
- Advanced biosensing and bioanalysis techniques
- Vascular Malformations Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Adrenal and Paraganglionic Tumors
University of Florida
2021-2024
Florida College
2022
Neurological Surgery
2021
Aga Khan University
2021
Stony Brook University
2021
INTRODUCTION: Pathogen recognition receptor (PRRs) activation is requisite for igniting the immune response and making tumor microenvironment ‘hot’ during oncogenesis. We theorized that these PRRs would remain present in ICI responsive tumors could be challenged using pan-PRR mimic to prospectively predict brain cancer immunogenicity checkpoint inhibitors (ICIs) METHODS: By layering mRNA into multilamellar nanoparticles (ML RNA-NPs), multiple pathogen receptors can simultaneously activated...
Paragangliomas are rare tumors that may present with cranial neuropathies when located along the skull base. Supratentorial paragangliomas less likely to secrete catecholamines but should be worked up, nonetheless. We highlight a case of female in her fourth decade found have petroclival lesion following initial presentation included one month tooth pain, dysphagia, diplopia, hoarseness and right hemifacial hypoesthesia. Magnetic resonance imaging brain demonstrated T2 hyperintense favored...
Neurologic sequalae of Noonan syndrome have been postulated in the literature. A topic significance is role RASopathy shared pathophysiology Syndrome and Chiari I malformation. In this unique case report, we present a patient with concomitant 4th ventricular outflow obstruction. The highlights importance close clinical suspicion population. We utilize to delve into intricacies known encourage ongoing investigation. Keywords: syndrome; malformation; RASopathy.
Abstract BACKGROUND Diffuse Midline Glioma (DMG) is an inoperable pediatric brain tumor with insufficient treatment options. Our group has developed a novel modality for this disease and others, using mRNA vaccines consisting of derived antigens in unique lipid-nanoparticle (NP). METHODS We have treated mice, canines, human patients primary tumors to define local immunotherapuetic response. our neonatally implanted DMG model NPs generated from total-tumor beginning day 31 used MRI, MR...
Pediatric middle cerebral artery aneurysms are often complicated by subsequent rupture and subarachnoid hemorrhage. Unruptured rare in infancy. Here, we present a case of 13-month-old male who underwent clip ligation for the treatment an incidental M3 aneurysm.
Abstract Therapies against glioblastoma (GBM) remain stymied by poor penetration across the blood-brain barrier (BBB) and systemic immunotolerance. These outcomes necessitate development of therapies simultaneously targeted to tumors while engineering peripheral immunity co-localize for synergistic responses. We developed RNA loaded lipid particles (LPs) function as inducers cytotoxic responses in GBM tumor microenvironment (TME) activators immunity. RNA-LP mediated response was studied mice...
Abstract BACKGROUND The dismal prognosis of high-grade gliomas demands novel treatment approaches. Through the development a mRNA lipid particle aggregate (RNA-LPA) vaccine, our lab has shown anti-tumor efficacy in preclinical murine studies and promising immunological responses canine glioma models human (Cell. 2024 May 9;187(10):2521-2535.e21). translational potential necessitates further investigating immune activation mechanism to allow greater applicability this therapy future....
Objective Transforaminal lumbar interbody fusion (TLIF) is a common approach and results in varying degrees of lordosis correction. The purpose this study to determine preoperative radiographic spinopelvic parameters that predict change postoperative segmental after TLIF. Materials & Methods This single surgeon retrospective review one-level two-level TLIFs from L3-S1. All patients underwent bilateral facetectomies, 10 mm TLIF cage (non-lordotic) insertions, pedicle screw-rod construct...
Inflammatory myofibroblastic tumor is a rare, poorly understood that has been found to occur in almost every organ tissue. Its location within the central nervous system uncommon, and patients tend present with nonspecific symptoms.A female her eighth decade presented neurosurgery clinic complaints of headache dizziness. Initial imaging was consistent low-grade, benign brain lesion region left choroidal fissure. She recommended for observation but returned 1 month later progressive symptoms...
Hydrocephalus treatment can be very challenging. While some hydrocephalic patients treated endoscopically, many will require ventricular shunting. Frequent shunt issues over a lifetime is not uncommon. Although most malfunctions are of the catheter or valve, distal failures occur as well. A subset accumulate non-functioning drainage sites.We present 27-year-old male with developmental delay who was shunted perinatally for hydrocephalus from intraventricular hemorrhage prematurity. After...
Imaging before specialist evaluation of abnormal head shape is associated with a delay in and an increase radiation exposure. A retrospective cohort study was performed to identify referral patterns after the implementation low-dose computed tomography (LDCT) protocol physician education examine intervention's impact on time Six hundred sixty-nine patients diagnosis at single academic medical center between July 1, 2014 December 2019 were reviewed. Demographics, information, diagnostic...
Glioblastoma is the most common malignant brain tumor, and thus it important to be able identify patients with this diagnosis for population studies. However, can challenging as diagnostic codes are nonspecific. The aim of study was create a computable phenotype (CP) glioblastoma multiforme (GBM) from structured unstructured data condition in large electronic health record (EHR).
A woman in her fourth decade presented with 1 month of dysphagia, hoarseness, diplopia, and right hemifacial hypoesthesia. Examination was notable for normal facial movement, hearing on audiogram, bilateral vocal cord mobilility. MRI brain demonstrated an avidly enhancing lesion thought to be a clival meningioma ([Fig. 1]). She underwent left combined transpetrosal craniotomy resection the tumor by neurosurgery neurotology 2]). Postoperatively, she awoke House–Brackmann grade II nerve palsy,...