A5100448978- Microbial Natural Products and Biosynthesis
- Bioactive natural compounds
- Natural Antidiabetic Agents Studies
- Marine Sponges and Natural Products
- Flavonoids in Medical Research
- Plant biochemistry and biosynthesis
- Genomics and Phylogenetic Studies
- Phytochemicals and Antioxidant Activities
- Synthesis of Organic Compounds
- Alkaloids: synthesis and pharmacology
- Synthesis of β-Lactam Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Medical and Biological Ozone Research
- Medicinal Plants and Bioactive Compounds
- Phytochemical compounds biological activities
- Microbial Metabolic Engineering and Bioproduction
- Chemical synthesis and alkaloids
- Enzyme Catalysis and Immobilization
- Phytochemistry and Biological Activities
- Chemical Synthesis and Analysis
- Retinal Development and Disorders
- Fungal Biology and Applications
- Traditional Chinese Medicine Analysis
- Biological and pharmacological studies of plants
University of Utah
2022-2025
Weifang University of Science and Technology
2020-2024
China Pharmaceutical University
2022
Ocean University of China
2015-2022
University of Edinburgh
2021
Centre for Inflammation Research
2021
Shanghai First People's Hospital
2017
Beijing University of Chinese Medicine
2011
University of Stuttgart
2007
Animal cytoplasmic fatty acid synthase (FAS) represents a unique family of enzymes that are classically thought to be most closely related fungal polyketide (PKS). Recently, widespread animal lipid metabolic has been described bridges the gap between these two ubiquitous and important enzyme classes: FAS–like PKSs (AFPKs). Although very similar in sequence FAS produce saturated lipids widely found animals, AFPKs instead structurally diverse compounds resemble bioactive polyketides. Little is...
The polyketide synthases (PKSs) in microbes and the cytoplasmic fatty acid humans (FASs) are related enzymes that have been well studied. As a result, there is paradigm explaining general terms how FASs repeatedly use set of enzymatic domains to produce simple fats, while PKSs much more complex manner pharmaceuticals other elaborate molecules. However, most animals also do not conform rules described microbes, including large family bridge metabolism, animal FAS-like (AFPKs). Here, we...
Nearly every animal species on Earth contains a unique polyketide synthase (PKS) encoded in its genome, yet no animal-clade PKS has been biochemically characterized, and even the chemical products of these ubiquitous enzymes are known only few cases. The earliest genome-encoded gene to be identified was SpPks1 from sea urchins. Previous genetic knockdown experiments implicated synthesis urchin pigment echinochrome. Here, we express purify SpPks1, performing biochemical demonstrate that...
A new indole alkaloid, named taichunamide H (1), was obtained from cultures of the fungus Aspergillus versicolor. With observation a carbon resonance with chemical shift 190.4 ppm, generally thought to be carbonyl, structure 1 initially proposed diastereomer that contains unique spiro-azetidine moiety. Further analysis compound using X-ray diffraction showed moiety should revised as fused-imine-containing pyrrole ring, at ppm assigned an imine carbon. Accordingly, also revised.
Abstract 2‐Fluorodeschloroketamine (2‐FDCK) as a substitute for ketamine has emerged among drug abusers in recent years. However, 2‐FDCK not been controlled or regulated many countries, which may be partly related to the lack of evidence on its abuse potential. In this study, we evaluated potential via tests conditioned place preference (CPP), locomotor sensitization, self‐administration and discrimination using reference. induced significant CPP at minimum dose 3 mg/kg mice, an effect...
Two new depsipeptides (1 and 2), together with three known related compounds, pestalotin (3), pestalotiopyrone L (4), PC-2 (5), were discovered in the extract of a mangrove derived fungus Sarocladium kiliense HDN11-112. The structures saroclides A B established by interpretation extensive NMR spectroscopic data X-ray crystallographic analysis. Compound 1 was also produced Simplicillium lamellicola HDN13-430. Compounds 2 inactive against five cancer cell lines four pathogenic microorganisms,...
As major active ingredients of the traditional Chinese medicine motherwort, stachydrine and leonurine were found to have protective effects against cerebral ischemia. However, their bioavailability in vivo was low, efficacy unsatisfactory, which limited further application. To solve these problems, conjugates based on structures designed synthesized. SL06 neuronal cell survival improvement, apoptosis restraining, activation superoxide dismutase (SOD) activity, inhibition lactic dehydrogenase...
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and lung parenchymal destruction. It has a very high incidence in aging populations. The current conventional therapies for COPD focus mainly on symptom-modifying drugs; thus, the development of new urgently needed. Qualified animal models could help to characterize underlying mechanisms can be used drug screening. Current models, such as lipopolysaccharide (LPS) or porcine pancreatic elastase...
C 10 H 15 NO 3 ,orthorhombic, P 2 1 (no.19) Source of materialThe title compound (alternative name:(1S,4S,5R)-1-isobutyl-4methyl-6-oxa-2-aza-bicyclo[3.2.0]heptane-3,7-dione) waso btained by lactonization (2S,3R,4S)-3-hydroxy-2-isobutyl-4methyl-5-oxo-proline in the presence bis(2-oxo-3-oxazolidinyl)phosphinic chloride [1][2][3].Purification flash chromatography (ethyl acetate/petroleum ether) and crystallization from dichloromethane gave b -lactone
Background: Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials in COVID19 without characterisation of Pharmacokinetics /Pharmacodynamics including safety data. One such drug is Nafamostat Mesylate.Methods: We present the findings a phase Ib/II open label, platform randomised controlled trial intravenous hospitalised patients with confirmed COVID-19 pneumonitis. Patients were assigned randomly standard care (SoC), or an alternative therapy. was administered as infusion at...
To compare the contents of flavonoids in axial root and lateral Scutellaria baicalensis, study their correlation.The 5 major flavonoids, baicalin, wogonoside, baicalein, wogonin oroxylin A, were determined S. baicalensis by HPLC. The correlation regression analysis between whole was carried out.The baicalin wogonoside showed no significant difference among upper part lower root, root. A a There only content existing results indicated that positively correlated, coefficient determination for...
Abstract Myricetin is a common plant-derived flavonoid and exhibits wide range of activities. However, myricetin also substantial limitations, such as its poor water-solubility low stability in body when it was administrated by oral. To solve these problems, series derivatives with different disaccharide groups were designed, synthesized evaluated their hypoglycemic All compounds displayed significant α-glucosidase inhibitory activity comparison acarbose vitro , which indicated that had good...