A5055289168- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Biomedical Text Mining and Ontologies
- Cell Image Analysis Techniques
- Genetics, Bioinformatics, and Biomedical Research
- 14-3-3 protein interactions
- PI3K/AKT/mTOR signaling in cancer
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Synthesis and biological activity
- Galectins and Cancer Biology
- Immune cells in cancer
- Academic Publishing and Open Access
- 3D Printing in Biomedical Research
- Science, Research, and Medicine
- Caveolin-1 and cellular processes
- Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Lymphatic System and Diseases
- Wnt/β-catenin signaling in development and cancer
- Lysosomal Storage Disorders Research
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- Vascular Tumors and Angiosarcomas
- Hippo pathway signaling and YAP/TAZ
- Chemokine receptors and signaling
University of Geneva
2014-2024
Délégation Provence et Corse
2024
Université Grenoble Alpes
2011-2018
Inserm
2011-2018
Unit of Virus Host Cell Interactions
2018
Centre National de la Recherche Scientifique
2018
Biology of Infection
2013-2014
Université Joseph Fourier
2011-2014
CEA Grenoble
2011-2014
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2011-2014
Abstract Recruitment of circulating monocytes is critical for tumour angiogenesis. However, how human monocyte subpopulations extravasate to tumours unclear. Here we show mechanisms extravasation CD14 dim CD16 + patrolling and intermediate proangiogenic (HPMo), using xenograft models live imaging transmigration. IFNγ promotes an increase the chemokine CX3CL1 on vessel lumen, imposing continuous crawling HPMo making these insensitive chemokines required their extravasation. Expression...
Abstract Objective Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that principally attacks synovial joints. However, accelerated atherosclerosis and increased cardiovascular morbidity mortality are major clinical consequences of endothelial dysfunction in RA patients. Tumor necrosis factor α (TNFα) the mediator inflammation RA, related to vascular injury by targeting VE‐cadherin, an endothelium‐specific adhesion molecule vital importance for endothelium integrity...
Vascular endothelial (VE)-cadherin is an cell-specific protein responsible for endothelium integrity. Its adhesive properties are regulated by post-translational processing, such as tyrosine phosphorylation at site Y685 in its cytoplasmic domain, and cleavage of extracellular domain (sVE). In hormone-refractory metastatic breast cancer, we recently demonstrated that sVE levels correlate to poor survival. the present study, determine whether kidney cancer therapies had effect on VE-cadherin...
The promising anti-angiogenetic properties of previously synthesized pyrazolyl ureas provided the rationale for synthesis novel 5-aminopyrazoles 2–5, differently decorated on pyrazole nucleus. All derivatives were tested by MTT assays and proved to be non-cytotoxic against eight different tumor cell lines normal fibroblasts. An EdU proliferation assay was carried out human foreskin fibroblasts VEGF stimulated umbilical vein endothelial cells which confirmed absence cytotoxicity compounds up...
Integrin-dependent crosstalk between cell-matrix adhesions and cell-cell junctions is critical for controlling endothelial permeability proliferation in cancer inflammatory diseases but remains poorly understood. Here, we investigated how acetylation of the distal NPKY-motif Integrin-β1 influences cell physiology barrier function. Expression an acetylation-mimetic β1-K794Q-GFP mutant led to accumulation immature accompanied by a transcriptomic reprograming cells, involving genes associated...
Vessel abnormalities are among the most important features in malignant glioma. Vascular endothelial (VE)-cadherin is of major importance for vascular integrity. Upon cytokine challenge, VE-cadherin structural modifications have been described including tyrosine phosphorylation and cleavage. The goal this study was to examine whether these events occurred human glioma vessels. We demonstrated that highly expressed tissue phosphorylated at site Y685, a previously found upon VEGF via Src...
Covalent modifications such as tyrosine phosphorylation are associated with the breakdown of endothelial cell junctions and increased vascular permeability. We previously showed that (VE)-cadherin was phosphorylated in vivo mouse reproductive tract Y685 a target site for Src response to growth factor vitro. In present study, we aimed understand implication VE-cadherin at cyclic angiogenic organs. To achieve this aim, generated knock-in carrying tyrosine-to-phenylalanine point mutation...
// Elda Meta 1 , Beat A. Imhof 2 Patricia Ropraz Richard J. Fish 3 Chiara Brullo Olga Bruno and Adama Sidibé Department of Pharmacy, Medicinal Chemistry Section, University Genoa, 16132 Italy Pathology Immunology, Geneva, 1211 Genève, Switzerland Genetic Medicine Development, Correspondence to: Sidibé, email: adama.sidibe@unige.ch Keywords: angiogenesis; novel target; pyrazolyl-urea; kinase inhibitors; DMPK Received: May 04, 2017 Accepted: July 26, Published: November 21, ABSTRACT The...
Cell Biology is a peer-reviewed journal aiming at publishing original articles and reviews communicating new impactful discoveries in life science. distributed by Rviews Press Open Access dedicated to reporting primary previously unpublished experimental data. Here are the aims editorial policies.
Authors need some information to provide that are dependent on the type of article format they want publish in Cell Biology. Herein, guidelines given authors for next submissions Biology publication following editorial requirements.
We previously reported that vascular endothelial growth factor induced (VE)-cadherin tyrosine phosphorylation at Y685 in a Src-dependent manner vitro. Here, we studied the occurrence of vivo female reproductive tract because it is unique model physiological remodeling dependent on factor. first developed and characterized an anti-phospho-specific antibody against site VE-cadherin to monitor along four phases mouse estrous cycle, termed proestrus, estrus, metestrus, diestrus. A dynamic...
(1) Background: different previously synthesized pyrazoles and imidazo-pyrazoles showed interesting anti-angiogenic action, being able to interfere with ERK1/2, AKT p38MAPK phosphorylation in manners potency; (2) Methods: here, a new small compound library, endowed the same differently decorated chemical scaffolds, has been synthetized obtain agents inhibit pathways involved inflammation, cancer human platelet aggregation. (3) Results: most of derivatives resulted block ROS production,...
Many persons with diabetes mellitus have limb ischemia, which is a major clinical problem. A subset of human monocytes that expresses TIE-2 may enhance neovascularization. We performed 179 phlebotomies on 142 patients (or donors), including 61 patients/donors without or ischemia (controls), 39 diabetic nonischemic and 42 severe requiring amputation. compared these groups for the presence TIE-2-positive proangiogenic monocytes. The proportion in venous blood (on hospital admission) was...
The recruitment of monocytes from the blood to targeted peripheral tissues is critical inflammatory process during tissue injury, tumor development and autoimmune diseases.This facilitated through a capture free flow onto luminal surface activated endothelial cells, followed by their adhesion transendothelial migration (transmigration) into underlying affected tissue.However, mechanisms that support preferential context-dependent monocyte subpopulations are still not fully...
Background: Mucopolysaccharidosis type I-Hurler (MPS1-H) is a severe genetic lysosomal storage disorder due to loss-of-function mutations in the IDUA gene. The subsequent complete deficiency of alpha l-iduronidase enzyme directly responsible progressive accumulation glycosaminoglycans (GAG) lysosomes which affects functions many tissues. Consequently, MPS1 characterized by systemic symptoms (multiorgan dysfunction) including respiratory and cardiac dysfunctions, skeletal abnormalities early...
The responsible commitment of life science experts in the evaluation and improvement research articles is crucial for an efficient scholarly publishing. In Cell Biology, expert roles competences are defined this article. Guidelines consistent objective manuscript reviewing evaluation.
Rviews Press launched Cell Reviews (Marseille, France), its first peer-reviewed journal for discussing the discoveries and achievements in life science. is an Open Access aiming at promoting responsibility, rigor fairness publishing experience. Here are outline aims as well editorial policies.
Scholarly publishing in life science requires implications of internal and external experts the evaluation improvement articles. This role is mainly played by editorial s peer-reviewers. Here are proposed some guidance for a consistent objective reviewing manuscript submitted publication Cell Reviews.
Publishing articles in Cell Reviews requires some essential information to provide a given article format of the journal. Here are highlighted guidelines for authors submitting that suite editorial requirements and Rviews Press journals as by this publication date.