A5089620709- Inflammatory Bowel Disease
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Microscopic Colitis
- GaN-based semiconductor devices and materials
- Ga2O3 and related materials
- Semiconductor materials and devices
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Silicon Carbide Semiconductor Technologies
- Glycosylation and Glycoproteins Research
- Edible Oils Quality and Analysis
- Eosinophilic Esophagitis
- Salivary Gland Disorders and Functions
- Metabolism and Genetic Disorders
- Advanced Photocatalysis Techniques
- ZnO doping and properties
- Autoimmune and Inflammatory Disorders
- Non-Invasive Vital Sign Monitoring
- Immunodeficiency and Autoimmune Disorders
- Blood Pressure and Hypertension Studies
- Advancements in Semiconductor Devices and Circuit Design
- Ultrasound in Clinical Applications
- Inflammatory mediators and NSAID effects
- Meat and Animal Product Quality
Osaka City General Hospital
2024
Setsunan University
2018-2023
Osaka City University
2012-2021
Toshiba (Japan)
2017-2021
Sumitomo Hospital
2014-2020
Wakayama University
2020
Chiba Cancer Center
2008-2019
Hyogo Prefectural Nishinomiya Hospital
2019
Krankenhaus der Elisabethinen
2015
Osaka Hospital
2014
The indigenous bacteria create natural cohabitation niches together with mucosal Abs in the gastrointestinal (GI) tract. Here we report that opportunistic bacteria, largely Alcaligenes species, specifically inhabit host Peyer's patches (PPs) and isolated lymphoid follicles, associated preferential induction of antigen-specific IgA GI were identified as dominant on interior PPs from naïve, specific-pathogen-free but not germ-free mice. Oral transfer intratissue uncultured into mice resulted...
Deletion of the distal region chromosome 1 frequently occurs in a variety human cancers, including aggressive neuroblastoma. Previously, we have identified 500-kb homozygously deleted at 1p36.2 harboring least six genes neuroblastoma-derived cell line NB1/C201. Among them, only KIF1Bbeta, member kinesin superfamily proteins, induced apoptotic death. These results prompted us to address whether KIF1Bbeta could be tumor suppressor gene mapped 1p36 Hemizygous deletion primary neuroblastomas was...
Background and aims Psychologic stress can affect the pathogenesis of inflammatory bowel disease (IBD), but precise contribution psychologic to IBD remains unclear. We investigated association with activity in patients IBD, especially terms mental state sleep condition. Methods This was a multi-center observational study comprising 20 institutions. Data were collected using survey forms for doctors questionnaires patients, clinical parameters investigated. Mental evaluated Center...
Higher mortality rates among psychiatric patients compared with the general population have been widely reported. On other hand, lower cancer for schizophrenics has occasionally pointed out. Few studies from Japan investigated patients, and this study is first large-scale follow-up in country.A total of 4980 admitted to a national mental hospital 1948 through 1982 were followed up until 31 August 1985. The standardized ratios (SMR) calculated comparison population, using person-years...
Semi-insulating layers (SIL) were formed on the surfaces of nominally undoped β-Ga 2 O 3 (010) single crystals by thermal oxidation. Capacitance–voltage measurement with double Schottky configuration was performed to evaluate increase in thickness SIL as a function annealing temperature and time. A SiO layer prepared surface prevented extension SIL, indicating that oxygen incorporation from air successive bulk diffusion dominated carrier compensation process. The activation energy...
We report the photoelectrode properties of an n-type β-Ga 2 O 3 single crystal in aqueous solutions. The conduction and valence band-edge potentials were found to be 1.1 V higher 2.5 lower than H + /H redox potentials, respectively. Photocurrent drastically increased as photogenerated carriers excited at a photon energy fundamental absorption edge 4.7 eV. incident photon-to-current conversion efficiency was 36% 5.2 Gaseous oxygen hydrogen evolved from Pt counter electrode, stoichiometric...
Spinal anaesthesia carries a risk of hypotension. We hypothesized that pleth variability index and perfusion would assess maternal volume status, thus, allow identification patients at higher developing hypotension after spinal for caesarean delivery.Fifty undergoing elective delivery were enrolled. All received with 0.5% hyperbaric bupivacaine (10 mg) fentanyl mcg). Blood pressure was measured every minute. Pleth automatically throughout the procedure using pulse oximetry on finger. In case...
Ideal biomarkers are required to be developed for the diagnosis and prediction of treatment inflammatory bowel disease (IBD). We have reported that alteration N-linked oligosaccharides immunoglobulin (Ig) G is a novel diagnostic marker IBD. Oligosaccharide alterations IgA, however, not been investigated in IBD patients.N- O-linked serum IgA purified from 32 patients with Crohn's (CD), 30 ulcerative colitis (UC), healthy volunteers (HV) were analyzed high-performance liquid chromatography...
Abstract KIF1Bβ, a member of the kinesin superfamily motor proteins, is haploinsufficient tumor suppressor mapped to chromosome 1p36.2, which frequently deleted in neural crest–derived tumors, including neuroblastoma and pheochromocytoma. While KIF1Bβ acts downstream nerve growth factor (NGF) pathway induce apoptosis, further molecular functions this gene product have largely been unexplored. In study, we report that destabilizes morphological structure mitochondria, critical for cell...
In the present study, a new clinical state of transient subclinical hypothyroidism in 12 early pregnant women is documented. The incidence was 18 (0.19%) among 9,453 examined this series Sapporo. characteristics gestational our study may be summarized as follows: temporarily increased TSH blood (11.7 +/- 6.3 microU/ml; mean S.D.) at 8.5 2.4 weeks gestation, accompanied with or without reduced FT4 which spontaneously return to normal 17.9 7.1 weeks; no subjective complaints and previous...
Agalactosyl immunoglobulin (Ig) G is increased in inflammatory bowel disease (IBD) similarly to rheumatoid arthritis (RA). The lectin complement pathway shown be activated through association of agalactosyl IgG with mannan-binding (MBL) RA. Functional changes agalactosylation IBD, however, have not yet been clarified.The ratio the agalactosyl/non-agalactosyl fraction fucosylated oligosaccharides (G0F/G2F) and serum MBL levels were analyzed 59 patients Crohn's (CD), 64 ulcerative colitis...
Background and Aim Differentiation between gastric adenocarcinoma low‐grade adenoma/dysplasia ( LGA ) on endoscopic forceps biopsy is difficult. We aim to clarify the incidence of carcinoma in specimens, obtained by resection ER ), from cases that had been diagnosed as (Vienna category 3) biopsy. Methods In this multicenter, prospective, observational study, patients with adenoma 3 or 4.1) were enrolled. All specimens subjected histopathological central review. Primary endpoint was 4.2 over)...