O Transtorno Afetivo Bipolar (TAB) é uma condição psiquiátrica crônica que afeta milhões de pessoas globalmente, exigindo tratamento contínuo para estabilização do humor e prevenção recaídas. Os antipsicóticos atípicos têm sido amplamente utilizados esse fim, mas seu uso levanta preocupações devido aos possíveis efeitos adversos metabólicos neurológicos. Justifica-se, portanto, a necessidade análise abrangente sobre eficácia segurança desses medicamentos. Objetiva-se, por meio desta...

<h3>Background:</h3> Increased understanding of pathophysiological mechanisms now confirms that systemic juvenile arthritis (sJIA) and adult-onset Still's disease (AOSD) represent a single clinical entity, differentiated only by age onset - below or above 16 years. Recent literature has documented subset pediatric patients with severe presentations (recurrent macrophage activation syndromes (MAS), reactions to biologics, early before 2 years age) who are prone develop lung (LD) [1]. Despite...

<h3>Background:</h3> Modifications in protein glycosylation have been shown to significantly contribute the immunopathogenesis of various immune-mediated diseases. However, a clinical glycobiomarker predict development and severity juvenile lupus erythematosus (jLES) is still unknown. <h3>Objectives:</h3> To explore role promising clinically-relevant characteristics disease activity patients with jLES. <h3>Methods:</h3> Patients diagnosed SLE before age 21 years-old were included....

Introduction: Helicobacter pylori (H. pylori), a Gram-negative bacterium, poses global health threat linked to chronic gastritis, gastric ulcers, and adenocarcinoma. This literature review addresses H. challenges, emphasizing therapeutic resistance modern treatment strategies. Methodology: Original works published from 2019 2023, available in total, presenting experimental clinical studies were included. Results: After the selection considering inclusion exclusion criteria, 17 articles...

<h3>Background</h3> Anti-SSa/Ro antibodies are among the common found in Systemic Sclerosis (SSc) patients (prevalence range 15–38%). Recent studies have suggested association of anti-SSa/Ro with interstitial lung disease (ILD) as well their prognostic role SSc patients, however its definitive importance is yet to be determined. <h3>Objectives</h3> To determine prevalence a cohort and clinical serological features. <h3>Methods</h3> Observational retrospective study was performed including...

The aim of this observational cross-sectional study was to determine the endotypic inflammatory pattern a sample patients with CRS in Brazil, correlate it olfactory function, and evaluate clinical severity disease.

<h3>Background</h3> Low bone mineral density (BMD) is highly prevalent in patients with systemic lupus erythematosus (SLE). However, determinants of BMD changes SLE are still largely unknown. <h3>Objectives</h3> The aim this study was to describe the clinical characteristics submitted a dual energy X-ray absorptiometry (DEXA), evaluating prevalence osteopenia/osteoporosis and searching for possible predictors loss these patients. <h3>Methods</h3> Retrospective observational 160 our...

<h3>Background</h3> The induction of auto-antibodies, such as anti-nuclear antibodies (ANA), is a well-known phenomenon during anti-TNF alpha treatment. However, the correlation this increase in ANA production and clinical response to anti-TNFα Spondyloarthritis (Spa) patients not yet determined. <h3>Objectives</h3> To determine impact positivity for (at baseline after treatment) persistency treatment Spa patients. <h3>Methods</h3> Observational retrospective cohort study was performed....

<h3>Background</h3> Intravenous immunoglobulin (IVIG) is effective in a wide range of clinical conditions, other than primary immunodeficiency, including rheumatic diseases. In fact, the era newer immunosuppressive drugs, there has been an over-increasing number indications for which IVIG tried with success. <h3>Objectives</h3> To evaluate effectiveness and adverse events off-label treatment different diseases, patients our Rheumatology Department. <h3>Methods</h3> We performed observational...

<h3>Background</h3> Short-term changes in biochemical markers of bone turnover have been suggested as predictors long-term response mass density (BMD) during teriparatide treatment. However, few data are available, particularly regarding increases hip BMD. <h3>Objectives</h3> The aim this study was to examine whether early predict BMD patients treated with teriparatide. <h3>Methods</h3> values at baseline and 18 months were obtained a LUNAR Expert 1320 R. β-C-telopeptide collagen 1...

<h3>Background</h3> Among rheumatoid arthritis (RA) patients, the influence of antinuclear antibodies (ANA) in clinical response to anti-TNFα treatment has been suggested. However, recent studies showed conflicting results. <h3>Objectives</h3> To determine impact positivity for ANA at baseline and persistency RA patients. <h3>Methods</h3> Observational retrospective cohort study was performed. Patients fulfilling American College Rheumatology criteria RA, who started their first between 2002...

<h3>Background</h3> Smoking is a known environmental risk factor for developing rheumatoid arthritis (RA), and also marker of worst clinical radiological prognosis. Despite this relation, the effect smoking on RA treatment effectiveness still controversial, with available reports suggesting deleterious effect. <h3>Objectives</h3> To analyse response in patients under biologics, addressing possible differences degree between those being treated anti-TNF alpha agents other biologics....

<h3>Background</h3> Corticosteroids (CS) are used on rheumatoid arthritis (RA) treatment for decades, due to their rapid and efficacious improvement of arthritis. With the recent advances in RA increasing awareness given CS side effects it should be expected that these drugs started being scarcely shorter periods time. <h3>Objectives</h3> Analyse variations dose patients with after start biologic therapy. existence differences between biologics regarding <h3>Methods</h3> A retrospective...

<h3>Background</h3> Minor salivary gland biopsy (MSGB) is a simple procedure that can be used for the diagnosis of Sjögren9s syndrome (SS) and other infiltrative diseases, such as amyloidosis, hemochromatosis, sarcoidosis. The revised version European criteria from American-European Consensus Group (AECG) in 2002 defined MSGB with focus score ≥1 (defined number inflammatory infiltrates at least 50 cells 4 mm² surface unit), major SS classification. also included American College...

<h3>Background</h3> Juvenile systemic lupus erythematosus (jSLE) is rare but associated with a worse prognosis than adult-onset disease. This has been attributed to higher risk of renal involvement, tendency have more active disease over time, receive intensive immunosuppressive treatment and accrue damage longer duration <h3>Objectives</h3> To describe the pattern expression special focus on outcomes in cohort patients jSLE tertiary hospital. <h3>Methods</h3> Retrospective analysis medical...

<h3>Background</h3> Tumour necrosis factor alpha (TNF-α) plays an important role in the pathogenesis of spondyloarthritis (SpA) and advent anti-TNF-α therapy represented a major therapeutic advancement its treatment. There is evidence that cigarette smoking increases production TNF-α reduces effectiveness anti-TNF drugs patients with rheumatoid arthritis. In early axial SpA it was demonstrated independently associated higher disease activity, increased structural damage, poorer functional...

<h3>Objective:</h3> To determine the effect of sleeping position on lung function prematurely born infants when post term, whether any was similar to that before discharge from neonatal unit, and if it differed according bronchopulmonary (BPD) status. <h3>Design:</h3> Prospective study. <h3>Setting:</h3> Tertiary unit. <h3>Patients:</h3> Twenty infants, median gestational age 30 weeks (range 25–32); 10 had BPD. <h3>Interventions:</h3> Before unit (median 36 postmenstrual (PMA)) were studied...

<h3>Background</h3> The induction of auto-antibodies, such as anti-nuclear antibodies (ANA), is a well-known phenomenon during anti-TNF alpha treatment. However, the correlation this increase in ANA production and clinical response to anti-TNFα Rheumatoid Arthritis (RA) patients not yet determined. <h3>Objectives</h3> To evaluate treatment its impact persistency inhibitor RA patients. <h3>Methods</h3> Observational retrospective cohort study was performed. Patients fulfilling American...

<h3>Background</h3> Neuropsychiatric involvement in systemic lupus erythematosus (NPSLE) includes the neurological syndromes of central, peripheral or autonomic nervous systems and psychiatric disorders. Some studies suggests that juvenile (jSLE) has a more serious course frequent neuropsychiatric than adult onset, coursing with significant morbidity mortality. Its prevalence ranges from 22 to 50.9%. <h3>Objectives</h3> To assess manifestations juvenile-onset SLE patients study predictors...

<h3>Background</h3> The 19809s ACR classification criteria for systemic sclerosis (SSc) show low sensitivity, especially in early or mild forms. A new set of has been developed by ACR/EULAR 2013. Applicability the clinical practice remains to be shown. <h3>Objectives</h3> To evaluate performance both SSc a Portuguese population. <h3>Methods</h3> Cross-sectional study including consecutive patients with diagnose (based on expert opinion) followed our rheumatology department. Clinical and...

<h3>Background</h3> Anterior uveitis (AU) is considered to be one of the most common extra-articular manifestations spondyloarthritis (SpA), and its prevalence may vary according genetic background study population. Uveitis can appear both before after onset osteoarticular symptoms. It lead serious complications that compromise visual function. <h3>Objectives</h3> The aim this was compare demographic, clinical laboratory data among SpA patients with without AU. <h3>Methods</h3>...

<h3>Background</h3> Systemic sclerosis (SSc) is known for its poor prognosis. However, it apparent that subsets of patients have bad outcomes sometimes after a short time disease duration whether some others will remain stable with milder disease. The factors impact in the prognosis and mortality are yet to be determined. <h3>Objectives</h3> To study causes dead survival predictors Portuguese SSc population. <h3>Methods</h3> Observational retrospective cohort was performed including...