A5100667247- Mesenchymal stem cell research
- Shoulder Injury and Treatment
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Periodontal Regeneration and Treatments
- Shoulder and Clavicle Injuries
- Osteoarthritis Treatment and Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Bone Tissue Engineering Materials
- MRI in cancer diagnosis
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- SARS-CoV-2 and COVID-19 Research
- Cancer, Hypoxia, and Metabolism
- Total Knee Arthroplasty Outcomes
- Spinal Hematomas and Complications
- Bacterial Infections and Vaccines
- Gallbladder and Bile Duct Disorders
- Peripheral Nerve Disorders
- Diagnosis and treatment of tuberculosis
- Spinal Fractures and Fixation Techniques
- Neurogenesis and neuroplasticity mechanisms
- Cancer Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Phytochemistry and Biological Activities
Sichuan University
1969-2020
West China Hospital of Sichuan University
1969-2020
Southern Medical University
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Cancer Hospital of Chinese Academy of Medical Sciences
2017
Mesenchymal stem cells (MSCs) and hyaluronic acid (HA) have been found in previous studies to great potential for medical use. This study aimed investigate the therapeutic effects of bone marrow mesenchymal (BMSCs) combined with HA on articular cartilage repair canines. Twenty-four healthy canines (48 knee-joints), male or female weight ranging from 5 6 kg, were operated induce defect model divided into 3 groups randomly which received different treatments: BMSCs plus (BMSCs-HA), alone,...
Stem cell therapy is considered an optimistic approach to replace current treatments for cartilage defects. Recently, human urine-derived stem cells (hUSCs), which are isolated from the urine, studied as a promising candidate many tissue engineering therapies due their multipotency and sufficient proliferation activities. However, it has not yet been reported whether hUSCs can be employed in In this study, we revealed that induced expressed chondrogenic-related proteins, including aggrecan...
People have been looking for tissue engineering approaches to treat large segment bone defects as replacements of autologous method. Cell-seeded scaffolds are promising candidates, but lack vascularization into the has greatly hindered their applications. To address this problem, we used a co-culture marrow derived mesenchymal stem cells (BMSCs) and endothelial progenitor (EPCs) on calcium phosphate ceramics better thus osteogenesis. Different ratios BMSC/EPC (3:1, 2:1, 1:1, 1:2, 1:3) in...
Engraftment of tissue-engineered bone plays a pivotal role in the treatment large defects. However, promoting thorough vascularization central area constructs remains great challenge for clinical application. Here, we developed three-dimensional (3D) co-culture system using biphasic calcium phosphate bioceramic (BCPB) scaffold seeded with rabbit peripheral blood-derived mesenchymal stem cells (PB-MSCs) and endothelial progenitor (EPCs) to improve new formation long segmental In vitro...
BACKGROUND:Growing evidence suggests that long non-coding RNAs (lncRNAs), as decoys of microRNAs (miRNAs), are involved in osteoarthritis (OA) progression, but the potential mechanism lncRNA SNHG15 OA remains unknown. Thus, present study explored molecular progression. MATERIAL AND METHODS:OA chondrocytes were created by 20 ng/ml IL-1β stimulation, and experimental model was destabilization medial meniscus (DMM) surgery. Cartilage histomorphology observed safranin fast green double dyeing....
Intervertebral disc degeneration (IVDD) is the most common pathogeny of lumbago. It pathological basis for a series spinal degenerative diseases. For long time, diagnosis and treatment lumbago have rendered difficult, since has not been identified. Therefore, present study aimed to investigate protective effect Sparstolonin B in preventing lumbar intervertebral degeneration, explored its potential mechanism rats. Firstly, effectively reduced histological score increased endplate porosity L2...
To retrospectively compare the detection and characterization of hepatic perfusion disorder (HPD) associated with focal liver lesions (FLLs) at contrast material-enhanced ultrasonography (US) by using contrast-enhanced computed tomography (CT) as reference standard.The study was approved local institutional ethics committee, informed consent waived. Three hundred fifty patients (mean age, 50 years ± 11 [standard deviation]; age range, 19-82 years; 168 women, 182 men) underwent US CT between...
This study aimed to investigate the correlation between transient segmental enhancement (TSE) of liver abscesses on contrast-enhanced ultrasound (CEUS) imaging and computed tomography (CT) scans.In total, 42 in 38 patients were evaluated with real-time CEUS CT imaging. The examinations performed within one 2 days each other all cases. initial reports observations TSE scans correlated later findings images. Contrast-enhanced was used as reference standard evaluate presence TSE. Relationships...
Considering that neutralizing antibody levels induced by two doses of the inactivated vaccine decreased over time and had fallen to low 6 months, homologous heterologous booster immunization programs have been implemented in adults China. The recombinant COVID-19 (ZF2001) after priming with healthy children adolescents has not reported. We performed an open-labeled, single-arm clinical trial evaluate safety immunogenicity ZF2001 among 240 population aged 3-17 years primary outcome was...
Objective To study the relationship between washout speed in contrast-enhanced ultrasound (CEUS) and differentiation grading pathology patients with hypervascular hepatocellular carcinoma (HCC). Methods Totally 271 who underwent complete resection for HCC from April 2009 to December 2014 at Nanchong Central Hospital were included this study. CEUS examinations perfomred all 2-3 days before liver resection. A timer on screen displayed time elapsed since saline flush was used determine...