A5067658527- Genetic factors in colorectal cancer
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Adrenal and Paraganglionic Tumors
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Lymphoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Neuroendocrine Tumor Research Advances
- Biliary and Gastrointestinal Fistulas
- Inflammatory Bowel Disease
- Tracheal and airway disorders
- Eosinophilic Esophagitis
- Gastrointestinal Tumor Research and Treatment
- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Pleural and Pulmonary Diseases
- Digestive system and related health
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2025
Instituto Nazionale Tumori Regina Elena
1999-2023
Fondazione IRCCS Istituto Nazionale dei Tumori
2023
National Cancer Institute
2020-2021
Azienda Ospedaliera Sant'Andrea
2012
Istituti Fisioterapici Ospitalieri
2004
Tumori Foundation
1999-2002
Esophagojejunal anastomosis leakage after total gastrectomy (TG) for esophagogastric junction (EGJ) adenocarcinoma (ADC) constitutes one of the most serious and sometimes life-threatening complications. Management remains controversial still challenging.A 198 patients operated type I II EGJ ADC were reviewed. Diagnosis was based on a combination clinical radiological findings. It classified including objective endoscopic parameters requiring different treatment.Anastomotic diagnosed in 14...
INTRODUCTION: Pancreatic cancer (PC) surveillance of high-risk individuals (HRI) is becoming more common worldwide, aiming at anticipating PC diagnosis a preclinical stage. In 2015, the Italian Registry Families Risk Cancer was created. We aimed to assess prevalence and incidence pancreatic findings, oncological outcomes, harms 7 years after inception, focusing on with least 3-year follow-up or developing events before. METHODS: HRI (subjects family history mutation carriers with/without...
Patients with hereditary non-poliposys colorectal cancer (HNPCC) have better prognosis than sporadic (CRC). Aim of our retrospective study was to compare the overall survival between CRC and HNPCC patients. We analyzed a cohort 40 (25 males 15 females) cases hospital consecutive series 573 (312 261 observed during period 1970–1993. In patients we performed mutational analysis for microsatellite instability. Survival rates were calculated by Kaplan-Meier method compared log rank test. The...
Primary rectal MALT lymphoma is a very rare entity among extranodal lymphomas and its therapeutic management has not been standardized. Different approaches including surgery, chemotherapy radiotherapy have proposed in the last decades. There reports on complete responses after anti-Helicobacter pylori therapy, also patients without serological or histological evidence of Helicobacter infection. In our patient we obtained response with therapy disease-free survival 34 months. Endoscopic...
This retrospective analysis is focused on the efficacy and safety of radioimmunotherapy (RIT) with Zevalin® in nine patients recurrent follicular lymphoma (FL) who were treated a consolidation setting after having achieved complete remission or partial FCR.The median age was 63 yrs (range 46-77), all relapsed histologically confirmed CD20-positive (grade 1 2) FL, at relapse they received FCR every 28 days: F (25 mg/m2x 3 days), C (1 gr/m2 day 1) R (375 mg/m2 4) for 4 cycles. Who least...
Primary rectal MALT lymphoma is a very rare entity among extranodal lymphomas and its therapeutic management has not been standardized. Different approaches including surgery, chemotherapy radiotherapy have proposed in the last decades. There reports on complete responses after anti-Helicobacter pylori therapy, also patients without serological or histological evidence of Helicobacter infection. In our patient we obtained response with therapy disease-free survival 34 months. Endoscopic...
Background: Endoscopic ultrasound (EUS) plays an important role in the diagnosis and staging of thoracic disease. Our report studies diagnostic performance clinical impact EUS fine needle aspiration (FNA) a homogenous cohort patients according to distribution enlarged MLNs or pulmonary masses. Methods: We retrospectively reviewed 211 EUS-FNA 200 consecutive with PET-positive para-mediastinal masses who were referred our oncological center between January 2019 May 2020. Results: The overall...
Aims Immunotherapy has dramatically changed advanced Non-Small Cell Lung Cancer (NSCLC) management improving oncological outcomes and reducing treatment related adverse events. However proximal distal airway fistulas as well esophageal leaks following chemo-immunotherapy have been reported. We report our experience in chemo-immunotherapy-related airways fistula management.
Aims to compare technical and clinical success of SEMS in proximal left sided neoplastic colonic stenosis.
Methods A retrospective analysis of endoscopic, radiological, laboratory and clinical data were carried out from January 2005 to December 2022 in a single onchological center, including only cases with at last 5 years follow up.
Aims In patients diagnosed with cancer, timely identification of distant metastases is crucial for optimal staging and prognosis. Adrenal gland originated mainly from lung (39%), breast (35%) GI tract, pancreas kidney. recent years, role ultrasound endoscopy biopsy (EUS-FNA/B) the detection adrenal has acquired greater importance. However, EUS right more challenging due to its position sub-optimal visualization. The diagnostic yield technical feasibility FNA/B lesions not been systematically...
Self-expandable metal stents (SEMSs) are frequently used in the setting of palliation for occluding, inoperable colorectal cancer (CRC). Among possible complications SEMS positioning, re-obstruction is most frequent. Its management controversial, potentially involving secondary stent-in-stent placement, which has been poorly investigated. Moreover, issue and more-than-two colonic stenting never assessed. We describe a case tertiary SEMS-in-SEMS also discuss our practice based on available...
Aims The minimally invasive procedures used in the diagnostic workup of patients with advanced non-small cell lung cancer (NSCLC) often provide poor yields pathological material suitable for molecular analyses. Not infrequently, DNA yield from small biopsies/cytological samples is insufficient assessment genomic biomarkers that inform personalised therapies. Idylla EGFR mutation test (IEMT) has been specifically designed to process formalin-fixed paraffin-embedded sections without requiring...
Regarding the staging of mediastinal lymph nodes before lung cancer surgery, Endobronchial Ultrasound Transbronchial Needle Aspirations (EBUS-TBNA) have proven to be highly sensitive and specific as well safe. Endoscopic Fine (EUS-FNA) plays an important role in diagnosis thoracic diseases, including cancer. In this study we analysed all patients underwent endoscopic procedures our ultrasound unit.Between January 2013 February 2018, performed a total 929 procedures, 432 EBUS-TBNA 497...
Ewing's sarcoma of the bone is a rare, highly aggressive tumor that typically affects children and young adults. Progress in treatment has improved survival from about 10%, before introduction chemotherapy, to 75% today for patients with localized tumors. On contrary, metastatic disease still poor prognosis, multidisciplinary approach essential improve outcome. Molecular techniques new imaging modalities are affecting diagnosis classification sarcoma. The most frequent sites metastases...