A5050867250- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Antimicrobial Peptides and Activities
- Supramolecular Self-Assembly in Materials
- Proteins in Food Systems
- Adsorption and biosorption for pollutant removal
- Nanopore and Nanochannel Transport Studies
- Advanced Nanomaterials in Catalysis
- Infant Nutrition and Health
- Sphingolipid Metabolism and Signaling
- Nanocluster Synthesis and Applications
- Pancreatic function and diabetes
- Food composition and properties
- Neurogenesis and neuroplasticity mechanisms
- Electrochemical sensors and biosensors
- Advanced Neuroimaging Techniques and Applications
- Food Allergy and Anaphylaxis Research
- Graphene and Nanomaterials Applications
- Pickering emulsions and particle stabilization
- Microplastics and Plastic Pollution
- Biosensors and Analytical Detection
- Recycling and Waste Management Techniques
- Prion Diseases and Protein Misfolding
- Metabolomics and Mass Spectrometry Studies
University of Palermo
2020-2025
Amyloid fibrils have recently emerged as promising building blocks for functional materials due to their exceptional physicochemical stability and adaptable properties. These protein-based structures can be functionalized create hybrid with a diverse range of applications. Here we report simple eco-friendly protocol generating amyloid from hen egg white lysozyme decorated gold nanoparticles that self-assemble in hydrogel. Reactive oligomeric species act reducing agents, enabling the...
The investigation of amyloid fibril formation is paramount for advancing our understanding neurodegenerative diseases and exploring potential correlated therapeutic strategies. Moreover, the self-assembling properties fibrils show promise development advanced protein-based biomaterials. Among methods employed to monitor protein aggregation processes, fluorescence has emerged as a powerful tool. Its exceptional sensitivity enables detection early-stage events that are otherwise challenging...
The interest on detailed analysis of peptide–membrane interactions is great in both fundamental and applied sciences as these may relate to functional pathogenic events. Such are highly dynamic spatially heterogeneous, making the investigation associated phenomena complex. specific properties membranes peptide structural details, together with environmental conditions, determine different events at membrane interface, which will drive fate system. Here, we use an experimental approach based...
Continuous progress has been made in the development of new molecules for therapeutic purposes. This is driven by need to address several challenges such as molecular instability and biocompatibility, difficulties crossing plasma membrane, host resistance. In this context, cell-penetrating peptides (CPPs) constitute a promising tool therapies due their intrinsic ability deliver cells tissues. These short have gained increasing attention applications drug delivery well antimicrobial...
Abstract Creatinine level in biological fluids is a clinically relevant parameter to monitor vital functions and it well assessed that measuring creatinine levels the human body can be of great utility evaluate renal, muscular, or thyroid dysfunctions. The accurate detection may have critical role providing information on health status represents tool for early diagnosis severe pathologies. Among different methods been introduced are evolving with increasing speed, fluorescence-based...
Protein-based materials recently emerged as good candidates for water cleaning applications, due to the large availability of constituent material, their biocompatibility and ease preparation. In this work, new adsorbent biomaterials were created from Soy Protein Isolate (SPI) in aqueous solution using a simple environmentally friendly procedure. microsponge-like structures produced characterized by means spectroscopy fluorescence microscopy methods. The efficiency these removing Pb2+ ions...
Abstract The formation of amyloid structures has traditionally been related to human neurodegenerative pathologies and, in recent years, the interest these highly stable nanostructures was extended biomaterial sciences. A common method monitor growth is analysis Thioflavin T fluorescence. use this selective dye, diffused worldwide, allows mechanistic studies supramolecular assemblies also giving back important insight on structure aggregates. Here we present experimental evidence...
Neurodegenerative diseases affect millions of people worldwide and the presence various physiological barriers limits accessibility to brain reduces efficacy therapies. Moreover, new carriers having targeting properties specific regions cells are needed in order improve therapies for disorder treatment. In this study, first time, Myelin nanoVesicles (hereafter defined MyVes) from brain-extracted myelin were produced. The MyVes have an average diameter 100-150 nm, negative zeta potential,...