A5048633130- Therapeutic Uses of Natural Elements
- Clay minerals and soil interactions
- Cancer-related molecular mechanisms research
- Iron oxide chemistry and applications
- Chemical Reactions and Isotopes
- Genomics, phytochemicals, and oxidative stress
- Cancer, Lipids, and Metabolism
- Body Contouring and Surgery
- Enzyme function and inhibition
- Nutrition, Genetics, and Disease
- Circular RNAs in diseases
- Parathyroid Disorders and Treatments
- Antimicrobial Peptides and Activities
- Genetic Syndromes and Imprinting
- Endoplasmic Reticulum Stress and Disease
- Retinoids in leukemia and cellular processes
- Growth Hormone and Insulin-like Growth Factors
- RNA regulation and disease
- Science, Research, and Medicine
- Lipid Membrane Structure and Behavior
- Telomeres, Telomerase, and Senescence
- Cancer Cells and Metastasis
- Computational Drug Discovery Methods
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
University of Palermo
2013-2023
Diabetes UK
2015
Multicavity halloysite nanotube materials were employed as simultaneous carriers for two different natural drugs, silibinin and quercetin, at 6.1% 2.2% drug loadings, respectively.
A dual drug-loaded HNT–CD glycocluster delivery system based on halloysite nanotubes and carbohydrate functionalized cyclodextrin for of natural drugs was developed.
We present a classic interactome bioinformatic analysis and study on competing endogenous (ce) RNAs for hTERT. The hTERT gene codes the catalytic subunit limiting component of human telomerase complex. Human reverse transcriptase (hTERT) is essential integrity telomeres. Telomere dysfunctions have been widely reported to be involved in aging, cancer, cellular senescence. network has analyzed using BioGRID interaction database (http://thebiogrid.org/) related tools such as Osprey...
Continuous progress has been made in the development of new molecules for therapeutic purposes. This is driven by need to address several challenges such as molecular instability and biocompatibility, difficulties crossing plasma membrane, host resistance. In this context, cell-penetrating peptides (CPPs) constitute a promising tool therapies due their intrinsic ability deliver cells tissues. These short have gained increasing attention applications drug delivery well antimicrobial...
It has been suggested that cancer stem cells (CSC) may play a central role in oncogenesis, especially undifferentiated tumours. Anaplastic thyroid carcinoma (ATC) characteristics suggestive of tumour enriched CSC. Previous studies the cell factor SOX2 preeminent hierarchical determining SW1736 ATC line. In detail, silencing is able to suppress expression markers analysed, strongly sensitizing line treatment with chemotherapeutic agents. Therefore, order further investigate ATC, competing...
To evaluate circulating soluble α-klotho (sαKL) levels in GHD children before and after 12 months of GH treatment (GHT).Auxological basal metabolic parameters, oral glucose tolerance test for insulin levels, sensitivity indices klotho were evaluated follow-up 58 56 healthy controls.At baseline, showed significantly lower growth velocity standard deviation score (SDS) (p < 0.001), bone/chronological age ratio peak area under the curve (AUC) arginine (ARG) (both p 0.001) glucagon stimulation...
RET kinase gain-of-function mutations represent the main cause of high aggressiveness and invasiveness medullary thyroid cancer (MTC). The selective inhibition is a suitable strategy for treatment this endocrine neoplasia. Herein, we performed an innovative ligand-based virtual screening protocol using DRUDITonline web service, focusing on as biological target. In process, thieno[3,2-c]quinolines 6a-e 7a-e were proposed new potential inhibitors. selected compounds synthetized by appropriate...