A5101477672- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Ovarian function and disorders
- Cardiovascular Disease and Adiposity
- Reproductive Biology and Fertility
- Lipid metabolism and disorders
- Diabetes Management and Research
- Thyroid Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Adrenal and Paraganglionic Tumors
- Gestational Diabetes Research and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Body Composition Measurement Techniques
- Childhood Cancer Survivors' Quality of Life
- Diabetes Treatment and Management
- Hormonal Regulation and Hypertension
- Glaucoma and retinal disorders
- Adrenal Hormones and Disorders
- Cancer-related Molecular Pathways
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
University of Palermo
2008-2018
Federico II University Hospital
2015
Tecnologie Avanzate (Italy)
2013
OBJECTIVE To individuate a novel sex-specific index, based on waist circumference, BMI, triglycerides, and HDL cholesterol, indirectly expressing visceral fat function. RESEARCH DESIGN AND METHODS Visceral adiposity index (VAI) was first modeled 315 nonobese healthy subjects. Using two multiple logistic regression models, VAI retrospectively validated in 1,498 primary care patients comparison to classical cardio- cerebrovascular risk factors. RESULTS All components of metabolic syndrome...
The Visceral Adiposity Index (VAI) is a sex-specific mathematical index, based on Waist Circumference (WC), Body Mass (BMI), triglycerides (TG) and HDL cholesterol (HDL) levels, indirectly expressing visceral adipose function insulin sensitivity. Our aim was to find the optimal cut-off points of VAI identifying dysfunction (VAD) associated with cardiometabolic risk in Caucasian Sicilian population.Medical check-up data 1,764 Primary Care patients (PC patients) were retrospectively...
Although there is still no clear definition of "adipose tissue dysfunction" or ATD, the identification a clinical marker altered fat distribution and function may provide needed tools for early condition cardiometabolic risk. Our aim was to evaluate correlations among various anthropometric indices [BMI, Waist Circumference (WC), Hip (HC), Waist/Hip ratio (WHR), Body Adiposity Index (BAI) Visceral adiposity (VAI)] several adipocytokines [Visfatin, Resistin, Leptin, Soluble leptin receptors...
Aliment Pharmacol Ther 2012; 35: 238–247 Summary Background Metabolic factors have been associated with liver damage in patients non‐alcoholic fatty disease (NAFLD). Aims To test a new marker of adipose dysfunction, the visceral adiposity index (VAI), NAFLD to assess whether or not it is host factors, and investigate potential correlation histological findings. Methods One hundred forty‐two consecutive were evaluated by biopsy, clinical metabolic measurements, including insulin resistance...
Metabolic factors have been associated with liver damage in patients genotype 1 chronic hepatitis C (G1 CHC). We tested visceral adiposity index (VAI), a new marker of adipose dysfunction G1 CHC, to assess its association host and viral link both histological findings sustained virological response (SVR). Two hundred thirty-six consecutive CHC were evaluated by way biopsy anthropometric metabolic measurements, including insulin resistance (IR), homeostasis model assessment (HOMA), VAI using...
Women with polycystic ovary syndrome (PCOS) frequently exhibit central obesity, glucose intolerance, atherogenic dyslipidemia and hypertension, which are characteristic features of a condition cardiometabolic risk. Our objective was to investigate the relationship between visceral adiposity index (VAI) phenotypic characteristics in women PCOS.We conducted cross-sectional case-control study our Endocrinology Outpatients Clinic. A total 220 PCOS (Rotterdam definition) 144 age- BMI-matched...
Currently available studies that fully analyse the metabolic parameters in patients with prolactinoma are scarce and discordant. The aim of this study was to evaluate effects cabergoline (CAB) treatment newly diagnosed relation disease control CAB dosage.This is a retrospective clinical-based therapy analysis.Forty-three (eight men, 35 women), aged 33·65 ± 11·23 years, were evaluated metabolically at baseline after 12 months treatment.Body mass index (BMI), systolic diastolic blood pressure,...
Diabetes mellitus (DM) is one of the most frequent complications Cushing's syndrome (CS). The aim this study was to define changes in insulin sensitivity and/or secretion relation glucose tolerance categories newly diagnosed CS patients.Cross-sectional on 140 patients with CS.A total 113 women (80 pituitary disease and 33 adrenal disease, aged 41.7±15.7 years) 27 men (19 eight 38.1±20.01 at diagnosis were divided according into normal (CS/NGT), impaired fasting (CS/prediabetes), diabetes...
Objective: To evaluate BRAFV600E mutation on consecutive fine-needle aspiration biopsy (FNAB) specimens in order to assess FNAB's usefulness preoperative papillary thyroid carcinoma (PTC) diagnosis with the contemporaneous analysis of RET/PTC1 and RET/PTC3 rearrangements obtained from ex vivo nodules. Design: Thyroid FNABs 156 subjects nodules 49 corresponding surgical samples were examined for presence BRAF by real-time allele-specific polymerase chain reaction, confirmed use a laser...
Background Recent publications suggest that neoplastic initiation and growth are dependent on a small subset of cells, termed cancer stem cells (CSCs). Anaplastic Thyroid Carcinoma (ATC) is very aggressive solid tumor with poor prognosis, characterized by high dedifferentiation. The existence CSCs might account for the heterogeneity ATC lesions. CD133 has been identified as cell marker normal cancerous tissues, although its biological function remains unknown. Methodology/Principal Findings...
Abstract BACKGROUND. BRAF V600E mutation and p27 kip1 expression have been introduced as novel indicators that may predict prognosis in different tumors, well papillary thyroid carcinomas. METHODS. Tissue samples from 214 consecutive patients who underwent total or near‐total thyroidectomy with histological diagnosis of carcinoma (PTC) ≤1 cm were analyzed for by a real‐time, allele‐specific amplification immunohistochemistry. RESULTS. The was detected 88 the tumors examined, significant...
SUMMARY Aims To assess whether host metabolic factors influence the degree of hepatic steatosis and fibrosis in patients infected with hepatitis C virus, to evaluate impact anti‐viral therapy on insulin resistance serum levels adipocytokines. Methods Clinical biochemical features, anthropometrical characteristics, fasting insulin, leptin, adiponectin resistin were measured ‘naïve’ chronic C, before, during after Peg‐Interferon‐alpha 2a plus Ribavirin. Results Forty‐eight included (M/F 28/20;...
BRAF V600E is the most common mutation found in papillary thyroid carcinoma (PTC). Tissue inhibitor of metalloproteinases (TIMP-1) and nuclear factor (NF)-κB have been shown to play an important role cancer. In particular, TIMP-1 binds its receptor CD63 on cell surface membrane activates Akt signaling pathway, which eventually responsible for anti-apoptotic activity. The aim our study was evaluate whether interplay among these three factors exists exerts a functional PTCs. To this purpose,...
The sexual dimorphism of the somatotroph axis has been documented, but whether acromegaly-related metabolic alterations are gender-dependent never investigated. aim study was to evaluate impact gender on parameters in acromegaly. We conducted a retrospective, comparative, multicenter study. 307 newly diagnosed acromegalic patients included were grouped by gender: 157 men (aged 48.01 ± 14.28 yr), and 150 women 48.67 14.95 yr; which 77 premenopausal 73 postmenopausal). measured each component...
The visceral adiposity index (VAI) has proved to be a marker of adipose dysfunction, strongly associated with insulin sensitivity in both the general and specific populations patients at metabolic risk. objective study was test VAI as useful tool assess early risk acromegaly. Twenty-four newly diagnosed acromegalic (11 women 13 men, aged 54.9 ± 13.6 yr) were grouped into those normal (group A, n = 13, 54.2%) high B, 11, 45.8%). Glucose, hemoglobin A1c, nadir area under curve (AUC) GH (AUCGH)...
GH replacement therapy in children with deficiency (GHD) mainly promotes linear growth. Not only have very few studies fully analyzed the metabolic consequences of therapy, but also question as to whether may affect adipokine secretion has been insufficiently investigated. Our aim was study effects on auxological data, lipid and glycemic profiles, insulin homeostasis (HOMA-IR) serum adipokines children.This a 1-year prospective study. Thirty-four GHD (11.6 +/- 2.6 years) thirty healthy...
Is it possible to distinguish metabolically healthy polycystic ovary syndrome (MH-PCOS) from unhealthy PCOS (MU-PCOS) by simple diagnostic tools such as body mass index (BMI), waist/hip ratio (WHR), at-risk category suggested Androgen Excess Society (AES) and visceral adiposity (VAI)? VAI could be an easy useful tool in clinical practice population studies for assessment of MU-PCOS. is a good indicator insulin sensitivity cardiometabolic risk oligo-ovulatory women with PCOS. We conducted...
MicroRNAs can be used as very efficient circulating biomarkers. The role of microRNAs in polycystic ovary syndrome (PCOS) and the effects antiandrogen therapy on microRNA expression is still not fully understood. A panel serum were retrotranscribed via looped reverse primer transcription specific for each miRNA quantified probe RT-PCR 16 Caucasian hyperandrogenic PCOS women selected according to Rotterdam criteria a subset seven patients after four months sequential antiandrogenic therapy....
Polycystic ovary syndrome (PCOS) is considered predominantly as a hyperandrogenetic and the evaluation of metabolic parameters insulin sensitivity not mandatory.PCOS diagnostic criteria [National Institute Health (NIH), Rotterdam Consensus (ROT), Androgen Excess Society (AES)] are unanimous recognized. We aimed to assess in women with suspected PCOS whether application three differently characterizes profile sensitivity.Retrospective study cohort admitted our Outpatient Clinic for PCOS.Two...
Objective On the basis of known diabetes risk in polycystic ovary syndrome (PCOS), recent guidelines Endocrine Society recommend use an oral glucose tolerance test (OGTT) to screen for impaired (IGT) and type 2 (T2DM) all women with PCOS. However, given high prevalence PCOS, OGTT would have a cost–benefit ratio. In this study, we identified, through receiver operating characteristic analysis, simple predictive markers composite endpoint (impaired fasting (IFG) or IGT IFG+IGT T2DM) PCOS...