A5074182337- Agriculture Sustainability and Environmental Impact
- Muscle Physiology and Disorders
- Environmental Impact and Sustainability
- Adipose Tissue and Metabolism
- Climate Change and Health Impacts
- Nutrition and Health in Aging
- Economic and Environmental Valuation
- Growth Hormone and Insulin-like Growth Factors
- Neurogenetic and Muscular Disorders Research
- RNA Research and Splicing
- GDF15 and Related Biomarkers
- Climate Change Policy and Economics
- Food Waste Reduction and Sustainability
- Botulinum Toxin and Related Neurological Disorders
- Hereditary Neurological Disorders
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Child Nutrition and Water Access
- Cerebral Palsy and Movement Disorders
- Cardiomyopathy and Myosin Studies
- Energy and Environment Impacts
AgResearch
2012-2022
New Zealand (NZ) is the world's largest exporter of sheep meat and an important beef. Given current concern about impact food production on climate change, it to understand extent greenhouse gas (GHG) emissions for NZ exported products. This Life Cycle Assessment study calculated cradle-to-grave carbon footprint beef produced in different markets. Sensitivity analyses were performed evaluate effect Global Warming Potential (GWP) metrics, sequestration by trees farms allocation methods at...
Insulin-like growth factors (IGFs) and myostatin have opposing roles in regulating the size of skeletal muscle, with IGF1 stimulating, inhibiting, growth. However, it remains unclear whether these proteins mutually dependent, or independent, roles. To clarify this issue, we crossed null (Mstn-/-) mice overexpressing Igf1 muscle (Igf1+) to generate six genotypes male mice; wild type (Mstn+/+ ), Mstn+/-, Mstn-/-, Mstn+/+:Igf1+, Mstn+/-:Igf1+ Mstn-/-:Igf1+ Overexpression increased mass mixed...
Myostatin inhibits myogenesis and there is reduced abundance of the mature protein in skeletal muscles adult male compared with female mice. This reduction probably occurs after translation, which suggests that it a regulated mechanism to reduce availability myostatin males. Reduced may, thereby, contribute development sexually dimorphic growth muscle. Our first objective was determine if decrease before linear phase aid growth, or afterwards maintain mass Mice were killed from 2 32 weeks...
Skeletal muscles of myostatin null (Mstn(−/−)) mice are more susceptible to atrophy during hind limb suspension (HS) than wild-type mice. Here we sought elucidate the mechanism for this susceptibility and determine if Mstn(−/−) can regain muscle mass after HS. Male were subjected 0, 2 or 7 days HS followed by 1, 3 reloading (n = 6 per group). lost from expressing fast type IIb myofibres was recovered in both genotypes days. Concentrations MAFbx MuRF1 mRNA, crucial ligases regulating...
Intramuscular injections of the paralytic botulinum neurotoxin A (Btx) and physical exercise are used in treatment chronic spasticity children with cerebral palsy. We tested whether Btx-induced paralysis and/or training would have differential effects on expression mechanosensing signalling genes implicated adaptive remodelling skeletal muscle. Juvenile (29-day-old) male rats were injected Btx or saline (NoBtx) into right gastrocnemius housed standard cages (NoEx) running wheels (Ex), for 3...
Growth and differentiation factor-11 (GDF-11) is a secreted protein that closely related to myostatin, known inhibitor of skeletal muscle development. The role GDF-11 in regulating growth remains unclear the pattern expression during post-natal has not been reported. Therefore, we sought determine its effect on myoblast proliferation differentiation. We collected gastrocnemius muscles from male female mice at 2, 3, 4, 6, 12, 20 32 weeks age (n = 6 per sex age). In addition, were col- lected...
Myostatin plays a fundamental role in regulating the size of skeletal muscles. To date, only single myostatin gene and no splice variants have been identified mammals. Here we describe splicing cryptic intron that removes coding sequence for receptor binding moiety sheep myostatin. The deduced polypeptide variant (MSV) contains 256 amino acid N-terminal domain, which is common to myostatin, unique C-terminus 65 acids. Western immunoblotting demonstrated MSV mRNA translated into protein,...
Insulin-like growth factor-1 (IGF1) is crucial for regulating post-natal and, along with myostatin (MSTN), regulates muscle size. Here, we sought to clarify the roles of these two genes in sexually dimorphic body and mass. In first study, established that Igf1 mRNA was increased a greater extent receptor earlier male, than female, gastrocnemius muscles during rapid phase (from 2 6 weeks) were unchanged, thereafter, 32 weeks age WT mice ( P < 0.001). second determine if supplemental IGF1...
Among the different sustainability metrics, carbon footprint is most commonly reported, but depletion of non-renewable resources such as fossil fuels, also important. This study aimed to calculate “cradle farm-gate” and resource milk production in Canterbury, New Zealand, comparing two farm systems: one pasture-based with a relatively small amount brought-in feed (Lincoln University Dairy Farm, LUDF) an average Canterbury farm. The estimate was 0.68 0.80 kg CO2-eq/kg fat protein-corrected...