A5032837067- Microbial Natural Products and Biosynthesis
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Synthesis of β-Lactam Compounds
- Polysaccharides and Plant Cell Walls
- Plant-derived Lignans Synthesis and Bioactivity
- Chemotherapy-induced organ toxicity mitigation
- Legume Nitrogen Fixing Symbiosis
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Microbial Metabolism and Applications
- Plant biochemistry and biosynthesis
- Plant Gene Expression Analysis
- Garlic and Onion Studies
- Glycosylation and Glycoproteins Research
- Microbial Metabolites in Food Biotechnology
- Plant Pathogenic Bacteria Studies
- Enzyme-mediated dye degradation
- Plant-Microbe Interactions and Immunity
- Enzyme Production and Characterization
KTH Royal Institute of Technology
2022-2024
AlbaNova
2021-2023
University of Padua
2012
Plant C-glycosylated aromatic polyketides are important for plant and animal health. These specialized metabolites that perform functions both within the plant, in interaction with soil or intestinal microbes. Despite importance of these compounds, there is still limited knowledge how they metabolized. The Gram-positive aerobic bacterium Deinococcus aerius strain TR0125 other species thrive a wide range harsh environments. In this work, we identified C-glycoside deglycosylation gene cluster...
(1,3;1,4)-β-D-Glucans are widely distributed in the cell walls of grasses (family Poaceae) and closely related families, as well some other vascular plants. Additionally, they have been found organisms, including fungi, lichens, brown algae, charophycean green bacterium Sinorhizobium meliloti. Only three members Cellulose Synthase-Like (CSL) genes families CSLF, CSLH, CSLJ implicated (1,3;1,4)-β-D-glucan biosynthesis grasses. Little is known about enzymes responsible for synthesizing...
Ellagic acid (EA), a natural polyphenol abundant in fruits and common our diet, is under intense investigation for its chemopreventive activity resulting from multiple effects. EA inhibits topoisomerase II, but the effects on human enzyme of urolithins, monolactone metabolites, are not known. Therefore, action several synthetic urolithins toward topoisomerases II was evaluated, showing that polyhydroxylated EA, EA-related compounds potent inhibitors α β isoforms at submicromolar...
Fighting cancer still relies on chemo- and radiation therapy, which is a trade-off between effective clearance of malignant cells severe side effects healthy tissue. Targeted treatment the other hand promising refined strategy with less systemic interference. The enzyme horseradish peroxidase (HRP) exhibits cytotoxic in combination indole-3-acetic acid (IAA). However, plant-derived out bounds for medical purposes due to its foreign glycosylation pattern resulting rapid immunogenicity. In...
Pyranose oxidase (POx, glucose 2-oxidase; EC 1.1.3.10, pyranose:oxygen 2-oxidoreductase) is an FAD-dependent oxidoreductase and a member of the auxiliary activity (AA) enzymes (subfamily AA3_4) in CAZy database. Despite general interest fungal POxs, only few bacterial POxs have been studied so far. Here, we report biochemical characterization POx from Streptomyces canus (ScPOx), sequence which positioned separate, hitherto unexplored clade phylogenetic tree. Kinetic analyses revealed that...
The Gram-negative bacterium Xanthomonas campestris is one of the most problematic phytopathogens, and especially pathovar ( Xcc ) that causes a devastating plant disease known as black rot it considerable interest to understand molecular mechanisms enable virulence pathogenicity. bacteria depend on lipoproteins (LPs) serve many important functions including control cell shape integrity, biogenesis outer membrane (OM) establishment transport pathways across periplasm. LPs are localized OM...