A5026866430- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Infections and bacterial resistance
- Antibiotics Pharmacokinetics and Efficacy
- Enterobacteriaceae and Cronobacter Research
- Vibrio bacteria research studies
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
Universidade Federal do Espírito Santo
2018-2023
Fundação Oswaldo Cruz
2014-2015
The most important resistance mechanism against β-lactam drugs is the production of carbapenemases. In this study, we report first identification Klebsiella pneumoniae carbapenemase (KPC)-2 and New Delhi metallo-β-lactamase (NDM)-1 in Enterobacter hormaechei subps. oharae from Brazil. detection carbapenemases was done by phenotypic assays, PCR, DNA sequencing, whereas performed conventional techniques, sequencing 16S rDNA gene, hsp60-genotyping. Molecular typing using pulsed-field gel...
Enzymes of the OXA-48 family have become some most important beta-lactamases in world. A new variant (OXA-370) was first described for an Enterobacter hormaechei strain isolated Rio Grande do Sul (southern region Brazil) 2013. Here we report detection blaOXA-370 gene 24 isolates belonging to three Enterobacteriaceae species (22 Klebsiella pneumoniae isolates, 1 cloacae isolate, and aerogenes isolate) collected from five hospitals de Janeiro, Brazil, 2013 2014. The showed a multidrug...
Infections caused by KPC-producing Klebsiella pneumoniae (Kp-KPC) are associated with high mortality rates due to the increased number of resistant isolates and scarcity therapeutic options. This scenario reinforces urgent need for new chemotherapeutics. Herein, we investigated effects 1,10-phenanthroline-5,6-dione (phendione) its metal-based complexes, [Cu(phendione)3](ClO4)2.4H2O (Cu–phendione) [Ag(phendione)2]ClO4 (Ag–phendione), both alone also combined carbapenems (meropenem (MEM),...