A5072464597- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Adenosine and Purinergic Signaling
- Heat shock proteins research
- Bacteriophages and microbial interactions
- Enzyme Structure and Function
- RNA regulation and disease
- Influenza Virus Research Studies
- Protein Structure and Dynamics
Baylor College of Medicine
2016-2023
Abstract Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against detrimental effects cellular stress. Under conditions stress they undergo drastic conformational rearrangements in order to bind misfolded substrate and prevent protein aggregation. Owing dynamic nature small oligomers, elucidating structural basis chaperone action oligomerization still remains a challenge. In understand organization sHSP we have determined crystal structures...
Rotavirus capping enzyme VP3 is a stable tetramer with unique RNA binding, RTPase, and helicase activities.
Nogo-66 receptor 1 (NgR1) binds a variety of structurally dissimilar ligands in the adult central nervous system to inhibit axon extension. Disruption ligand binding NgR1 and subsequent signaling can improve neuron outgrowth, making an important therapeutic target for diverse neurological conditions such as spinal crush injuries Alzheimer’s disease. Human serves mammalian orthoreovirus (reovirus), but mechanism virus–receptor engagement is unknown. To elucidate how mediates cell entry...
Following infection, viruses synthesize nonstructural proteins that mediate viral replication and promote dissemination. Viruses from the family Reoviridae encode are required for formation of progeny viruses. Although different in diverge primary sequence, they functionally homologous appear to facilitate conserved mechanisms dsRNA virus replication. Using vitro cell culture approaches, we found mammalian reovirus protein σNS binds stabilizes RNA is genome synthesis. This work contributes...
ABSTRACT Human Nogo-66 receptor 1 (NgR1) is a for mammalian orthoreoviruses (reoviruses), but the mechanism of virus-receptor engagement unknown. NgR1 binds variety structurally dissimilar ligands in adult central nervous system (CNS) to inhibit axon outgrowth. Disruption ligand binding and subsequent signaling can improve neuron regrowth, making an important therapeutic target diverse conditions such as spinal crush injuries Alzheimer disease. To elucidate how mediates cell entry reovirus,...