A5072402364- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Behavioral and Psychological Studies
- Nuclear Receptors and Signaling
- Histone Deacetylase Inhibitors Research
- Genetics and Neurodevelopmental Disorders
- Child and Animal Learning Development
- Olfactory and Sensory Function Studies
- Anesthesia and Neurotoxicity Research
- Neuropeptides and Animal Physiology
- Sleep and Wakefulness Research
- Autism Spectrum Disorder Research
- Neurogenesis and neuroplasticity mechanisms
- Nicotinic Acetylcholine Receptors Study
- Memory Processes and Influences
- Advanced MRI Techniques and Applications
- Plant and animal studies
- Mindfulness and Compassion Interventions
Oregon Health & Science University
2014-2024
University of Pennsylvania
1998-2004
University of California, San Diego
1998
Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both memory synaptic plasticity. The current model for the action of HDAC assumes that they alter gene expression globally thus affect processes in a nonspecific manner. Here, we show enhancement hippocampus-dependent hippocampal plasticity by is mediated transcription factor cAMP response element-binding protein (CREB) recruitment transcriptional coactivator acetyltransferase CREB-binding (CBP) via domain CBP....
Significance Noninvasive brain imaging holds great promise for expanding our capabilities of treating human neurologic and psychiatric disorders. However, key limitations exist in human-only studies, the ability to use animal models would greatly advance understanding function. Mice offer sophisticated genetic molecular methodology, but correlating these data functional mouse has remained a major hurdle. This study is first, knowledge, whole-brain show large-scale architecture with...
Several recent studies have shown that chromatin, the DNA-protein complex packages genomic DNA, has an important function in learning and memory.Dynamic chromatin modification via histone deacetylase (HDAC) inhibitors acetyltransferases (HATs) may enhance hippocampal synaptic plasticity hippocampus-dependent memory.Little is known about effects of HDAC on extinction, a process through which ability previously conditioned stimulus, such as conditioning context, to evoke response diminished.We...
Recent accounts of memory suggest that retrieval a learning experience transforms into labile state requires period protein synthesis to be reconsolidated fixed state. In this article, we show the impairments in behavior caused by inhibitor anisomycin given after are temporary and thus not likely reflect disruptions synthesis-dependent reconsolidation process. Mice received injections either initial acquisition or contextual fear conditioning. When followed acquisition, freezing was impaired...
Spaced training is generally more effective than massed for learning and memory, but the molecular mechanisms underlying this trial spacing effect remain poorly characterized. One potential basis differential modulation, by distinct temporal patterns of neuronal activity, protein synthesis-dependent processes that contribute to expression specific forms synaptic plasticity in mammalian brain. Long-term potentiation (LTP) a type modification may be important certain memory storage To explore...
Many molecular accounts of long-term memory storage postulate that the synthesis new proteins is necessary for changes in neuronal function. These experiments generally have examined learning occurs as associations are acquired between neutral and biologically important stimuli. Little known about importance protein establishment memories extinction, which relations established during acquisition severed. Extinction appears to be an active process results formation rather than simple erasure...
The current study examined whether a postretrieval drug memory could be disrupted by the beta-adrenoceptor antagonist propranolol, administered following reactivation in cocaine-mediated conditioned place preference paradigm. Following cocaine conditioning, rats were given test of preference, followed immediately intraperitoneal administration propranolol or saline. Rats that received showed no for cocaine-paired floor during subsequent test, while vehicle-treated continued to express floor....
A key finding in studies of the neurobiology learning memory is that amygdala critically involved Pavlovian fear conditioning. This well established delay-cued and contextual conditioning; however, surprisingly little known role trace Trace conditioning, which CS US are separated time by a interval, requires hippocampus prefrontal cortex. It possible recruitment cortical structures conditioning alters compared to delay where overlap. To investigate this, we inactivated male C57BL/6 mice with...
Previous work has demonstrated post-retrieval impairment in associative learning paradigms, including those mediated by drugs of abuse, using nonspecific β-adrenergic receptor (β-AR) antagonists. Remarkably little is known about the role specific β-AR subtypes, or other adrenergic receptors, these effects. The current study examined effects β 1 and 2 , as well α -adrenergic antagonism following retrieval a cocaine conditioned place preference (CPP). We found that rats administered antagonist...
Methylphenidate (MPH, Ritalin) is a norepinephrine and dopamine transporter blocker that widely used in humans for treatment of attention deficit disorder narcolepsy. Although there some evidence targeted microinjections MPH may enhance fear acquisition, little known about the effect on extinction. Here, we show MPH, administered before or immediately following extinction contextual fear, will retention C57BL/6 mice. Animals received (2.5–10 mg/kg) an session showed decreased freezing...
Four experiments assessed the effects of trial (T) and intertrial (I) durations on magazine approach behavior in rats. In Experiments 1 2, different groups animals were conditioned with various combinations I T durations. The rate acquisition, terms number trials required to reach acquisition criteria, generally was faster trained large I:T ratios. There also differences terminal response rates between identical ratios but absolute Differences evident at end conditioning persisted during a...
Much is known about the neurobiology of memory storage for learned fear. In contrast, molecular mechanisms underlying extinction fear are just beginning to be delineated. Here, we investigate role protein kinase A (PKA) in contextual by using conventional and temporally regulated transgenic approaches that allow us inhibit PKA activity neurons within brain regions thought involved extinction. Strikingly, reduction facilitated development extinction, without interfering with original memory....