A5064210740- Voice and Speech Disorders
- Oral and Maxillofacial Pathology
- Sarcoma Diagnosis and Treatment
- Tracheal and airway disorders
- Bone Tumor Diagnosis and Treatments
- Head and Neck Cancer Studies
- Corneal surgery and disorders
- Head and Neck Anomalies
- Ear and Head Tumors
- Corneal Surgery and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Soft tissue tumor case studies
- Dysphagia Assessment and Management
- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Cancer and Skin Lesions
- Lymphoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Vascular Tumors and Angiosarcomas
- Chronic Lymphocytic Leukemia Research
- Neurofibromatosis and Schwannoma Cases
- Ear Surgery and Otitis Media
Centre Hospitalier Universitaire de Saint-Étienne
2012-2023
Institute Cancer De La Loire Lucien Neuwirth
2020-2022
Université Jean Monnet
2021-2022
Hôpital Nord
2009-2021
Centre Hospitalier Universitaire de Besançon
2014
Biologie, ingénierie et imagerie pour l'Ophtalmologie
2014
Institut Universitaire de France
2014
Hôpital Pasteur
2007
Bellevue Hospital Center
2005
Bellevue University
2004
Immune system affects prognosis of various malignancies. Anti-immune pathways like PD-L1 and CTLA4 are used by the tumor to overcome immune they serve as immunotherapy targets. The microenvironment head-and-neck squamous cell carcinoma (SCCHN) has not been sufficiently studied.152 SCCHN were immunohistochemically studied for expression CD3, CD8, CD57, CD4, granzyme b, CD20, CD163, S100, PD-L1, CXCR4.CD3, CD57 stromal S100 higher density is a good prognostic factor (p=0.02, 0.01, 0.02, 0.03...
Despite immune microenvironment of head and neck squamous cell carcinoma (HNSCC) has been studied, there are no sufficient data on the role tumor stroma factors. The aim study was to explore prognostic predictive these factors in a large series HNSCC.This is retrospective 266 patients with laryngeal pharyngeal SCC. Clinical were correlated following histological parameters: tumor-stroma ratio (TSR), budding activity (BA), nests size (CNS), type.Stroma-rich tumors, budding, smaller CNS at...
Abstract Objectives The disruption or defect of the myometrium in uterine scar a cesarean section (CS) has been known by various names, such as niche, isthmocele, deficient scar, pouch, diverticulum. Symptomatology, risk factors for niche development, and available treatment modalities have recently studied. However, histologic features this disease remain unknown. Methods eight niches are thoroughly described summary most important aspects literature is provided. Five cases CS scars without...
Background Brain metastases (Bmets) are frequent; however, limited data exist on the efficacy of immunotherapy in these lesions. The aims study were to analyze immunohistochemical expressions programmed death ligand 1 (PD-L1) and CD8 Bmets compare them with their paired primary tumors, as well correlate results clinicopathological features. Methods This is a retrospective 233 patients 111 primaries. Clinical, histological, molecular recorded compared PD-L1 expressions. statistical analysis...
Induction chemotherapy (IC) is occasionally used in head and neck cancer, leading to less extensive surgery reduced need for irradiation. Factors predicting the response IC have not been determined. In this study, we investigated clinical histopathologic factors that predict IC.Head squamous cell carcinomas from 81 patients were analyzed; factors, histologic parameters, expression of p16 p53 correlated with prognosis.Factors a good nonoropharyngeal localization, rich lymphocytic tissue...
Purpose: To quantify cell survival and tissue structure preservation of porcine cornea stored in a bioreactor (BR) that recreates transcorneal pressure gradient equivalent to intraocular (IOP) renews the medium. Methods: A BR comprising endothelial epithelial chambers was machined biocompatible material. The cornea, securely held, separated chambers. Medium flow inside chamber were maintained by peristaltic pump. In chamber, corneal surface alternatively exposed air specific Two transparent...
Chordomas are rare sarcomas that usually treated by surgery and/or radiotherapy since these chemo-resistant tumors, but immunotherapy could be a possible option for chordoma patients. However, few reports investigating the composition of immune microenvironment exist. We immunohistochemically studied 81 chordomas regarding their factors and compared them with clinicopathological data. Macrophages CD4 cells were most prominent inflammatory cell populations, followed CD8 T cells, while CD20 B...