A5102877587- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Inflammatory mediators and NSAID effects
- Protein purification and stability
- Neuropeptides and Animal Physiology
- Monoclonal and Polyclonal Antibodies Research
- Water Treatment and Disinfection
- Metal complexes synthesis and properties
- Urinary and Genital Oncology Studies
- PI3K/AKT/mTOR signaling in cancer
- Ferrocene Chemistry and Applications
- Diverse Scientific Research Studies
- Virology and Viral Diseases
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Fecal contamination and water quality
- Virus-based gene therapy research
- Heme Oxygenase-1 and Carbon Monoxide
- Biosimilars and Bioanalytical Methods
Islamic Azad University, Tehran
2023
Iran University of Medical Sciences
2023
Babraham Institute
2021-2023
Abzena (United Kingdom)
2021-2023
SUNY Downstate Health Sciences University
2023
Université de Montréal
2020-2023
Tarbiat Modares University
2020-2023
Razi Vaccine and Serum Research Institute
2020
Agricultural Research & Education Organization
2020
University College London
2011-2018
Abstract Defects in antitumor immune responses have been associated with increased release of prostaglandin E2 (PGE2) as a result overexpression cyclooxygenase (COX)-2 by tumors. In this report, we examine the effects PGE2 on CD8+ T-cell generated both cross-presenting dendritic cells and direct priming tumor cells. Our data show that inhibits cell maturation, resulting abortive activation naive T cells, is dependent interleukin-10 production Interaction naïve presence vitro results...
Abstract Tumor-expressed ICAM-1 interaction with LFA-1 on naïve tumor-specific CD8+ T cells not only stabilizes adhesion, but, in the absence of classical B7-mediated costimulation, is also able to provide potent alternative costimulatory signaling resulting production antitumor cytotoxic lymphocyte (CTL) responses. This study shows that overproduction prostaglandin (PG) E2 by metastatic murine renal carcinoma (Renca) inhibited direct priming CTL responses vivo preventing IFNγ-dependent...
In this study, we generated human MHC Class I-restricted CD4+ T cells specific for Epstein-Barr virus (EBV) and cytomegalovirus (CMV), two herpesviridae associated with lymphoma, nasopharyngeal carcinoma medulloblastoma, respectively. Retroviral transfer of virus-specific, HLA-A2-restricted TCR-coding genes that recognized HLA-A2/peptide multimers produced cytokines when stimulated II-deficient presenting the relevant viral peptides in context HLA-A2. Peptide titration revealed had a 10-fold...
A key predictor for the success of gene-modified T cell therapies cancer is persistence transferred cells in patient. The propensity less differentiated memory to expand and survive efficiently has therefore made them attractive candidates clinical application. We hypothesized that redirecting specialized niches BM support differentiation would confer increased therapeutic efficacy. show overexpression chemokine receptor CXCR4 CD8+ (TCXCR4) enhanced their migration toward vascular-associated...
Hypoxia in tumours is known to cause resistance conventional chemotherapeutic drugs. In contrast, little about the effects of hypoxia on targeted anti-cancer This study evaluated effect a series clinically approved tyrosine kinase inhibitors (TKIs).The (0.1% oxygen) activity cytotoxic drugs (5-fluorouracil, doxorubicin and vinblastine), hypoxia-activated prodrug tirapazamine 9 TKIs was determined panel cell lines. Where had marked chemosensitivity, Western blot analysis conducted determine...
Abstract Ag receptors used for cancer immunotherapy are often directed against tumor-associated Ags also expressed in normal tissues. Targeting of such can result unwanted autoimmune attack tissues or induction tolerance therapeutic T cells. We a murine model to study the phenotype and function cells redirected double minute protein 2 (MDM2), that shows low expression many Transfer MDM2-TCR–engineered into bone marrow chimeric mice revealed recognition hematopoietic maintained cell function,...
Background: Many studies have been showed that certain illnesses including fungi and bacterial infections can be transmitted to human by contaminated swimming pools water. The main objective of the present study was detect microbial (bacterial fungi) chemical (pH chlorine levels) pollutions all water in Hamadan city, Iran . Methods: This a cross-sectional carried out on 6 (including four indoor two outdoor pools) summer 1999 Hamadan, west Iran. sampling done twice per week randomly evening...
Background: Acanthamoeba belongs to the free-living amoebae genus that causes a widespread infection with different severities in humans and animals. Treatment of these opportunistic protozoan infections is still not safe or effective. The aim present study was evaluate effect spring extract Artemisia aucheri on vitro. Method: Trophozoites cysts were cultured non-nutrient agar plates containing bacteria Escherichia coli. Macrophage cells RPMI-1640 medium. : Different concentrations extracts...
Abstract Combination approaches using stimulatory cytokines, checkpoint inhibitors, chemotherapy and/or radiation therapy are known to improve overall survival of cancer patients. Recombinant interleukins (IL) have had limited clinical success due short pharmacokinetics, inefficient tumor targeting and more frequent dosing, leading toxicities. To address these issues, we developed a novel platform that delivers immunomodulators in either mono- or bispecific format. The consists fully human,...