A5079547403- Head and Neck Cancer Studies
- Endometrial and Cervical Cancer Treatments
- Lysosomal Storage Disorders Research
- Advanced Radiotherapy Techniques
- Colorectal and Anal Carcinomas
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Glycogen Storage Diseases and Myoclonus
- Effects of Radiation Exposure
- Cervical Cancer and HPV Research
- Oral health in cancer treatment
- Erythrocyte Function and Pathophysiology
- Pancreatic and Hepatic Oncology Research
- Airway Management and Intubation Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Nausea and vomiting management
- Cardiac tumors and thrombi
- Hepatocellular Carcinoma Treatment and Prognosis
- Anesthesia and Pain Management
- MRI in cancer diagnosis
- Tracheal and airway disorders
- Sphingolipid Metabolism and Signaling
- Hematological disorders and diagnostics
- Death Anxiety and Social Exclusion
Delhi State Cancer Institute
2016-2024
Institute of Medical Sciences
2023-2024
Banaras Hindu University
2023
PAREXEL International (India)
2017-2019
Mount Sinai Hospital
2018
Barkatullah University
2017
Tata Memorial Hospital
2007-2013
Indian Institute of Toxicology Research
2012
King George's Medical University
2009-2012
Advanced Centre for Treatment, Research and Education in Cancer
2011-2012
Mucositis, a radiotherapy-associated toxicity, is an important factor determining morbidity and treatment compliance. Gastrointestinal mucositis in patients undergoing radiotherapy may also depend on time of administration radiation addition to several other factors. The presence any correlation between the severity acute gastrointestinal cervical carcinoma irradiation was prospectively evaluated.A total 229 with were randomized morning (8:00-10:00 AM) evening (6:00-8:00 PM) arms. incidence...
Patients of head and neck cancer undergoing radiotherapy develop oral mucositis. The severity mucositis may also depend on the time administration radiation apart from patient-related factors. most radiosensitive phase cell cycle (G2-M) occurs in late afternoon evening human mucosa; therefore, it is more vulnerable to injury evening. present study evaluated prospectively acute carcinoma patients irradiated morning (08:00-11:00 h) versus afternoon/evening (15:00-18:00 h).A total 212 were...
Abstract Background Clinical trials for rare diseases often include multiple endpoints that capture the effects of treatment on different disease domains. In many diseases, primary endpoint is not standardized across trials. The win ratio approach was designed to analyze interest in clinical and has mostly been applied cardiovascular Here, we data from COMET, a phase 3 trial late-onset Pompe disease, illustrate how this can be used orphan drug context. Methods All possible participant...
A major problem in cancer pharmacology is the unpredictability of outcome therapy, both terms tumor response and host toxicity. Pharmacogenetic variability associated with drug metabolizing enzyme systems a determinant variations these outcomes.A case-control study 100 male cases head neck squamous cell carcinoma equal number healthy controls was conducted. Genomic DNA isolated from blood samples collected patients studied by PCR-RFLP technique for CYP2D6 polymorphism. All received three...
Background: Bone marrow metastasis by a nonhematologic malignancy signifies advanced stage of disease and confers poor prognosis. The aim this study was to analyze clinical presentation, hematological profile, biochemical radiological patterns bone involvement in patients with metastatic malignancies retrospectively. Materials Methods: Ninety procedures were done cases for suspected or as part staging procedure. Results: Sixteen out 90 showed malignancies. most common metastasize malignant...
To determine variation in the actual doses delivered to organs at risk and target patients treated for localized carcinoma of prostate using image-guided radiotherapy.Ten with helical TomoTherapy underwent daily localization megavoltage CT, on which prostate, rectum bladder were recontoured. The planned adaptive module was used dose recalculation. study endpoints analyse variations certain dose-volume parameters (BD 2cc , RD BV 100% 70% RV ), maximum anteroposterior (AP) lateral rectal...
12070 Background: Although the reports suggest 15-25% cancer patients receiving highly- and moderately emetogenic chemotherapy (HEC MEC) experience nausea vomiting beyond day 5, majority of clinical trials focus on delayed induced (CINV) only during first 5 days treatment. Here we present a real world observational data with fixed combination IntraVenous (Fos)NEtupitant Palonosetron (IV NEPA) in preventing nausea/vomiting extended phase among HEC/MEC. Methods: An open label, single arm,...
Abstract Introduction:Metastatic carcinoma in the lymph nodes of neck from an unknown primary is relatively rare, accounting for about 3% all head and cancers. Management secondary undetermined controversial.Materials Methods:The case records patients treated Department Radiotherapy, Chatrapati Shahuji Maharaj Medical University, Oct 1999 to Sep 2004, were studied with without a known tumor analyzed detail elucidate outcome various treatment modalities stages disease. One hundred forty found...
Present study investigated the relationships among psychosocial, spiritual well being and death anxiety advance stage cancer patients in order to improve prognosis quality of life as reduce their sufferings. By studying various beings anxiety, it would be possible identify psychological needs help treatment make them mentally strong cope with disease. Data was collected from Sample 80 patients, six exclusive hospitals western central zones India. Patients were identified per clinical details...
The baroreflex is an important afferent mechanism controlling autonomic functions. As nerves course through the neck, they are susceptible to damage by neck irradiation in head and cancer patients. With increased survival of patients because improved therapy, cardiovascular morbidity mortality them have become apparent this clinical concern. There few case reports failure as a chronic sequel irradiation.The present study evaluated changes cardio-autonomic tone postural reflex neck-irradiated...
Molecular targeted agents have lower hematological toxicity. However, specific side-effects such as allergic rashes, skin reactions and high cost limit their use. We report a case of 35-year-old male patient with carcinoma left tonsil treated concurrent cetuximab radiotherapy. After four weeks treatment, the developed sudden onset pain in calf region radiating to foot. Doppler study limb revealed complete thrombosis superficial femoral, popliteal proximal tibial arteries veins no flow...
Purpose: Induction chemotherapy has shown to provide consistent benefit for local control in primary treatment of advanced oropharyngeal cancer. The beneficial role chemoradiation following induction over concurrent not been evaluated. Present study evaluates the same prospectively. Method: Out 135 patients locally carcinoma, 105 were found eligible and randomized treat either with consisting 2-3 cycles cisplatin 5- Florouracil followed by low dose weekly based chemoradiotherapy (treatment...
Objective: Bone marrow examination is essential for staging Hodgkin's Lymphoma (HL) at the time of diagnosis to determine correct treatment and prognosis disease. The aim this study was analyze clinical presentation, hematological profile, biochemical radiological presentation patterns bone involvement in patients with Hodgkins lymphoma retrospectively. Materials Methods: procedures were done 49 cases a part procedure. Results: 9 showed by lymphoma. Clinically, 1 patient staged as stage II...
Abstract Introduction: The aim of the study was to evaluate prognostic significance histopathological differentiation in treatment outcome locally advanced carcinoma cervix. Materials and Methods: This retrospective includes 167 patients cervix treated between January 2006 December 2008 who have received definitive chemoradiation. Results:: number with well (85 [50.9%]) moderately differentiated (76 [45.5%]) nearly equal poorly variety having only 6 (3.6%) patients. On completion out...