A5010940382- Appendicitis Diagnosis and Management
- Breast Cancer Treatment Studies
- Intraperitoneal and Appendiceal Malignancies
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
- BRCA gene mutations in cancer
- DNA Repair Mechanisms
- FOXO transcription factor regulation
- Hernia repair and management
- Chronic Lymphocytic Leukemia Research
- Renal cell carcinoma treatment
- Lymphoma Diagnosis and Treatment
- Big Data and Business Intelligence
- Cancer Cells and Metastasis
- Autoimmune Neurological Disorders and Treatments
- Pancreatitis Pathology and Treatment
- Economic and Financial Impacts of Cancer
- Neuroendocrine Tumor Research Advances
- Meta-analysis and systematic reviews
- Big Data Technologies and Applications
- Lung Cancer Research Studies
Mayo Clinic in Arizona
2023-2024
Collaborative Group (United States)
2022-2023
Henry Ford Health System
2022
Harbor–UCLA Medical Center
2021
Olive View-UCLA Medical Center
2021
Providence Regional Medical Center Everett
2021
Columbia University Irving Medical Center
2021
Harborview Medical Center
2021
Cornell University
2021
Cedars-Sinai Medical Center
2015-2021
The mesoderm- and epithelial-mesenchymal transition-associated transcription factor FOXC1 is specifically overexpressed in basal-like breast cancer (BLBC), but its biochemical function not understood. Here, we demonstrate that controls stem cell (CSC) properties enriched BLBC cells via activation of Smoothened (SMO)-independent Hedgehog (Hh) signaling. This non-canonical Hh mediated by Gli2. Furthermore, show the N-terminal domain (aa 1-68) binds directly to an internal region 898-1168)...
Antibody-drug conjugates (ADC) have emerged as potent antitumor drugs that provide increased efficacy, specificity, and tolerability over chemotherapy for the treatment of cancer. ADCs generated by targeting cysteines lysines on antibody shown but these products are heterogeneous, instability may limit their dosing. Here, a novel technology is described enables site-specific conjugation toxins to antibodies using chemistry produce homogeneous, potent, highly stable conjugates. We developed...
Multiple farnesylated proteins are involved in signal transduction cancer. Farnesyltransferase inhibitors (FTIs) have been developed as a strategy to inhibit the function of these proteins. As FTIs proliferation melanoma cell lines, we undertook study assess impact FTI advanced melanoma. also important for T activation, measurement effects on was pursued. A 3-stage trial design with maximum 40 patients and early stopping if there were no responders first 14, or fewer than 2 28 patients....
Abstract Oncogene amplification confers a growth advantage to tumor cells for clonal expansion. There are several, recurrently amplified oncogenes throughout the human genome. However, it remains unclear whether this recurrent is solely manifestation of increased fitness resulting from random mechanisms, or if genomic locus-specific mechanism plays role. Here we show that ERBB2 oncogene at 17q12 susceptible palindromic gene amplification, characterized by inverted (palindromic) duplication...
Background and Objectives Pre‐operative localization of small bowel neuroendocrine tumors (SBNET) is important for operative planning. The aim was to determine the effectiveness pre‐operative imaging double‐balloon enteroscopy (DBE) in identifying extent disease. Methods Database review identified 85 patients with primary SBNET between 2006 2013. Analysis included who underwent imaging, endoscopy, surgery at our institution. Results Average age 60.7 years. Sixty‐six (77.1%) had a NET ileum....
Abstract Surface ectoderm (SE) cells give rise to structures including the epidermis and ectodermal associated appendages such as hair, eye mammary gland. In this study, we validate a protocol that utilizes BMP4 γ-secretase inhibitor DAPT induce SE differentiation from human induced pluripotent stem (hiPSCs). hiPSC-differentiated expressed markers suggesting their commitment lineage. Computational analyses using integrated quantitative transcriptomic proteomic profiling reveal TGFβ...
A patient's belief in the likely success of a treatment may influence outcomes, but this has been understudied surgical trials.To examine association between patients' baseline beliefs about likelihood with outcomes antibiotics for appendicitis Comparison Outcomes Antibiotic Drugs and Appendectomy (CODA) trial.This was secondary analysis CODA randomized clinical trial. Participants from 25 US medical centers were enrolled May 3, 2016, February 5, 2020. Included participants who randomly...
Targeting more than one molecule in multifactorial diseases involving several disease mediators may provide improved therapeutic efficacy. Psoriasis is a which interleukin (IL)-6 and IL-23 are important because they facilitate development of Th17 cells; widely accepted to be associated with psoriasis. To meet the need for new therapeutics, we aimed create clinically relevant bispecific drug, by combining inhibitory properties anti-IL-6 anti-IL-23 antibodies, exhibiting high affinity,...
Breast cancers arising in the setting of hereditary breast cancer genes BRCA1 and BRCA2 are most commonly classified as basal-like (BLBC) or luminal cancer, respectively. BLBC is an aggressive subtype associated with liver lung metastases poorer prognosis than other subtypes for which chemotherapy only systemic therapy. Multiple immunohistochemical markers used to identify subtype, including absence estrogen receptor alpha, progesterone receptor, human epidermal growth factor 2. Forkhead box...
High-dose interleukin-2 (IL-2) is the only approved immunologic therapy for advanced melanoma, but response rates are low and significant toxicities limit treatment to otherwise healthy patients. g209-2M a nanopeptide engineered mimic an epitope of gp100 melanocyte differentiation protein that recognized in human leukocyte antigen (HLA)-restricted manner by melanoma tumor-infiltrating lymphocytes some Previous reports indicated administration peptide could induce g209-reactive circulating T...
Small bowel neuroendocrine tumors (SBNET) account for most gastrointestinal tumors. Patients often present with late-stage disease; however, there is little information regarding factors that contribute to recurrence. Database review identified 301 patients diagnosed SBNET between 1990 and 2013. Univariate analysis included who underwent complete resection. Survival was estimated by the Kaplan–Meier method. A total of 147 met study criteria. Average age 60 years (range 21–91); 49 per cent...
The Forkhead box C1 (FOXC1) transcriptional factor is a critical biomarker for basal-like breast cancer (BLBC). We recently reported that FOXC1 promotes stem cell properties in BLBC by activating Smoothened (SMO)-independent Hedgehog (Hh) signaling, suggesting FOXC1-mediated mechanism function and anti-Hh therapy resistance.
A screening test has been developed for the presumptive identification of Torulopsis (Candida) glabrata from other common clinical isolates yeast-like fungi. An interlaboratory comparison a protocol consisting morphology on cornmeal Tween 80 agar and trehalose fermentation at 42 degrees C was successful in differentiating T. taxa that are frequent or possible isolates. The results 517 yeast isolates, 241 which were glabrata, compared with their final via commercial systems (API20C Yeast...
Journal Article Appendiceal neoplasms in patients treated with antibiotics for acute appendicitis: secondary analysis of the CODA randomized clinical trial Get access Writing Group Collaborative Search other works by this author on: Oxford Academic Google Scholar British Surgery, znad240, https://doi.org/10.1093/bjs/znad240 Published: 27 July 2023 history Received: 09 March Revision received: June Accepted: 06
The burden of gastric cancer involving Hispanic patients in the United States is growing as both population and incidence this group increases. This compounded by presentation with advanced disease socioeconomic challenges shaping care. We sought to describe demographics, factors, treatment, survival experience adenocarcinoma.Patients adenocarcinoma diagnosed between 2004 2015 (n=90,737) National Cancer Database were retrospectively identified. Patients ethnicity compared against...
From a review of the literature it appears that local trauma is factor in genesis oral hyperkeratoses. The major concern systemic influence has been focused upon vitamin A metabolism. Existing evidence indicates deficiency can produce hyperkeratosis and therapeutic amounts exert an anti- or dekeratinizing effect on normal hyperkeratotic mucosa. An attempt was made this investigation to study, under double-blind conditions (vitamin versus placebo supplementation), problem leukoplakia terms...
This ACM Ubiquity Symposium presented some of the current thinking about big data developments across four topical dimensions: social, technological, application, and educational. While 10 articles can hardly touch expanse field, we have sought to cover most important issues provide useful insights for curious reader. More than two dozen authors from academia industry provided shared their points view, focus interest outlines future research. Big digital has changed will change world in many...