A5055651609- Neural dynamics and brain function
- Nicotinic Acetylcholine Receptors Study
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Photoreceptor and optogenetics research
- Vestibular and auditory disorders
- Neuroscience and Music Perception
- Monoclonal and Polyclonal Antibodies Research
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Neuropeptides and Animal Physiology
University of Strathclyde
2015-2020
University of Nottingham
2017-2019
MRC Institute of Hearing Research
2017-2019
Medical Research Council
2017-2019
The phase of low-frequency network activity in the auditory cortex captures changes neural excitability, entrains to temporal structure natural sounds, and correlates with perceptual performance acoustic tasks. Although these observations suggest a causal link between rhythms perception, it remains unknown how precisely they affect processes by which populations encode sounds. We addressed this question analyzing responses anesthetized rats using stimulus–response models. These models...
Abstract Neuronal activity can modify Alzheimer’s disease pathology. Overexcitation of neurons facilitate progression whereas the induction cortical gamma oscillations reduce amyloid load and improve cognitive functions in mouse models. Although previous studies have induced by either optogenetic activation parvalbumin-positive (PV+) or sensory stimuli, it is still unclear whether other approaches to induce also be beneficial. Here we show that PV+ basal forebrain (BF) increases burden,...
Animal models of tinnitus are essential for determining the underlying mechanisms and testing pharmacotherapies. However, there is doubt over validity current behavioural methods detecting tinnitus. Here, we applied a stimulus paradigm widely used in test (gap-induced inhibition acoustic startle reflex GPIAS) whilst recording from auditory cortex, showed neural response changes that mirror those found tests. We implanted guinea pigs (GPs) with electrocorticographic (ECoG) arrays recorded...
A common method for measuring changes in temporal processing sensitivity both humans and animals makes use of GaP-induced Inhibition the Acoustic Startle (GPIAS). It is also basis a detecting tinnitus rodents. However, link to has not been properly established because GPIAS yet used objectively demonstrate humans. In guinea pigs, Preyer (ear flick) myogenic reflex an acoustic startle test, while humans, it eye-blink reflex. Yet, have vestigial remnant reflex, which can be detected by skin...
Abstract Neuronal activity can modify Alzheimer’s disease pathology. Although overexcitation of neurons facilitate progression, the induction cortical gamma oscillations reduce amyloid load and improve cognitive functions in mouse models. These beneficial effects be caused by either optogenetic activation parvalbumin-positive (PV+) or 40 Hz repetitive sensory stimuli. However, given fact that induced multiple mechanisms, it is still unclear whether other approaches to induce also beneficial....