A5081663154- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Antimicrobial Peptides and Activities
- Peptidase Inhibition and Analysis
- Piperaceae Chemical and Biological Studies
King's College London
2020-2024
Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen. secreted by Candida albicans and critical for driving infection host immune responses several model systems. However,
Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents inducers. Whilst some expressed constitutively at mucosal tissues, the primary site of many infections, others elicited in response to pathogens. In context Candida albicans, fungal factors inducing release these innate immune molecules poorly defined. Herein, we identify candidalysin a potent trigger several key AMPs known possess anti-Candida functions. We also find extracellular ATP be an...
Candida albicans (C. albicans) is a dimorphic commensal human fungal pathogen that can cause severe oropharyngeal candidiasis (oral thrush) in susceptible hosts. During invasive infection, C. hyphae invade oral epithelial cells (OECs) and secrete candidalysin, pore-forming cytolytic peptide required for pathogenesis at mucosal surfaces. Candidalysin produced the hyphal invasion pocket triggers cell damage responses OECs. also activates multiple MAPK-based signaling events collectively drive...
ABSTRACT Candida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma membrane host cells thereby promoting disease and immunopathology. Candidalysin was first identified C. strain SC5314, but recent investigations have revealed candidalysin “variants” differing amino acid sequence isolates , related species dubliniensis C...