A5066041481- MicroRNA in disease regulation
- Hepatitis C virus research
- Systemic Lupus Erythematosus Research
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Hibiscus Plant Research Studies
- Natural Antidiabetic Agents Studies
- ATP Synthase and ATPases Research
- RNA Interference and Gene Delivery
- Pesticide Exposure and Toxicity
- Medicinal plant effects and applications
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Phytase and its Applications
- Diverse Scientific Research Studies
- Rabbits: Nutrition, Reproduction, Health
- Head and Neck Cancer Studies
- Biological and pharmacological studies of plants
- Phytochemistry and Biological Activities
- Drug-Induced Hepatotoxicity and Protection
- Agriculture, Water, and Health
- Enzyme Production and Characterization
- Cancer-related gene regulation
Biotech Park
2020-2024
Gauhati University
2015-2022
Indian Institute of Technology Guwahati
2020-2021
Gauhati Medical College and Hospital
2017-2019
Oral squamous cell carcinoma (OSCC) is one of the common type cancer in humans. A combinatorial approach has been done by using paclitaxel (PTX), 5-fluorouracil (5-FU) and ascorbic acid (AA) loaded solid lipid nanoparticles (SLN) for its treatment. SLN were made high-speed homogenization ultrasonication technique they used alone combination to check their efficacy against OSCC induced animal model. Pharmacokinetics biodistribution study optimized formulations PTX, 5-FU AA was performed. The...
Aims: This study was designed to determine if vitamin D receptor (VDR), carrier globulin/binding protein (GC), and cytochrome P-450 family 2, subfamily R, polypeptide 1 (CYP2R1) gene polymorphisms are risk factors in the development of hepatocellular carcinoma (HCC) hepatitis C virus (HCV)-infected patients from Northeast India. Materials Methods: A total 351 HCV-infected were enrolled which 167 diagnosed with chronic (CHC), 124 liver cirrhosis (LC), 60 HCC together 102 age- sex-matched...
Malaria disease is an infectious disease, endemic to tropical and sub-tropical regions causing half a million people's deaths every year. Bioactive compounds derived from medicinal plants are used treat malaria disease. H. cannabinus C. capsularisare two edible abundant in distribution the Assam region, India. In this study, in-vitro in-silico investigations were performed explore anti-malarial activity of plant extracts against Plasmodium falciparum with its validation hemocompatibility on...
Promoter methylation reflects in the inactivation of different genes like O 6 -methylguanine-DNA methyltransferase DNA repair gene and runt-related transcription factor 3, a known tumor suppressor various cancers such as esophageal cancer. The promoter was evaluated for 3 CpG, CHH, CHG context (where H is A, T, or C) by next-generation sequencing. status correlated with quantitative messenger RNA expression. In addition, expression risk factors tobacco, alcohol, betel nut consumption,...
Chronic hepatitis C virus (HCV) infection leads to variable outcomes, ranging from prolonged slow hepatic damage leading cirrhosis, and hepatocellular carcinoma (HCC). Polymorphism in cytokines IL-10 IL-12 that impact the immune response HCV may play a role determining this outcome. This study was aimed determine if polymorphisms IL-12B contribute susceptibility risk of developing HCC patients Northeast India. - 1082, -819, -592 -1188 were genotyped by polymerase chain reaction-restriction...
Background: To investigate polymorphisms in heat shock proteins A1B and A1L (HOM) associated risk of oesophageal carcinoma Northeast India.Materials Methods: The study includes cancer (ECA) patients attending general outpatient department (OPD) endoscopic unit Gauhati Medical College.Patients were diagnosed based on histopathological findings.Genomic DNA was typed for HSPA1B1267 HSPA1L2437 SNPs using the polymerase chain reaction with restriction fragment length polymorphisms.Results: A...
Introduction: Toxic hepatitis refers to the inflammation of liver that may follow on inhalation, ingestion or parenteral administration a number pharmacological and chemical agents. The traditional knowledge ethnic tribal people using plants as herbal medicine has become very significant gives both positive negative impact in treatments diseases. A pilot study been conducted among locality Assam, India during year 2016-17. local practitioners (locally known “Bez” “Ojha”) were providers...
Background: Malaria, an infectious protozoan disease endemic to tropical and sub-tropical regions, results in around half a million deaths annually across various age groups. The emergence of drug-resistant strains Plasmodium falciparum presents critical challenge existing treatments. Hibiscus cannabinus Corchorus capsularis, both edible medicinal plants within the Malvaceae family, have traditionally been employed for their properties treating bacterial infections viral fevers.Study purpose...
Introduction: X-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision pathway, as scaffold protein that brings together proteins of DNA complex. XRCC1 is reported to be candidate influence on cancer risk. Oesophageal Cancer (EC) eighth common type worldwide and sixth cause related deaths world [Zhang et. al., 2009]. The aim our present study was assess association rs1799782 (Arg194Trp), rs25489 (Arg280His) rs25487 (Arg399Gln) gene polymorphisms with oesophageal...
Background: The habit of using masticatories is quite common among the population state Assam. There are numerous types available throughout state, most which include areca nut in different forms, accompanied with beetle leaves and tobacco other associated substances added for flavor. Aim: To determine level nitrite present prevailing state. Materials & Methods: classical Griess method was used estimation these Assam (n=35) basic diazotization principle spectrophotometric determination....
Introduction: Promoter methylation results in the alteration of different gene expressions such as like O6-methylguanine-DNA methyltransferase (MGMT) and Runt-related transcription factor 3 (RUNX3) various cancers oesophageal cancer (EC). MGMT is a DNA repair enzyme RUNX3 novel tumor suppressor gene. CpG In this study, we analyzed status promoters (EC) to evaluate relationship between expression EC. Methods: A total 80 EC tissue samples were for promoter by methylation-specific polymerase...
Abstract The features of translational repression by micro-RNA can cause various diseases in humans. liver-specific microRNA (mir122) is primarily involved tissue tropism during HCV infection. This study focuses on evaluating host serum miR-122 as a prognostic marker A positive expression was observed CHC patients followed HCC compared to healthy controls. difference median levels and (p < 0.000) found contrast Cirrhosis = 0.511). threefold higher liver cirrhosis than chronic hepatitis....
Background: The microRNA (miRNA) mediated translational repression can cause various diseases in humans. liver-specific miRNA (microRNA-122 (miR-122)) is primarily involved tissue tropism during hepatitis C virus (HCV) infection which ultimately leads to hepatocellular carcinoma (HCC). Objectives: This study focuses on evaluating host serum miR-122 as a prognostic marker HCV-induced carcinoma. Methods: Evaluation of expression was carried out by quantitative real time PCR. Results: Positive...