A5085818737- High voltage insulation and dielectric phenomena
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Plasma Diagnostics and Applications
- Power Transformer Diagnostics and Insulation
- Vacuum and Plasma Arcs
- Semiconductor materials and devices
- Electron and X-Ray Spectroscopy Techniques
- Microbial Natural Products and Biosynthesis
- Electrostatic Discharge in Electronics
- Marine Sponges and Natural Products
- Lightning and Electromagnetic Phenomena
- Particle accelerators and beam dynamics
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Phytochemicals and Antioxidant Activities
- Synthetic Organic Chemistry Methods
- Phytochemistry and Bioactive Compounds
- Marine Toxins and Detection Methods
- Magnetic confinement fusion research
- Thermal Analysis in Power Transmission
- Sesquiterpenes and Asteraceae Studies
- Superconducting Materials and Applications
- Genomics and Phylogenetic Studies
- Seaweed-derived Bioactive Compounds
Hiroshima University
2015-2023
The Ohio State University
2022
Saitama University
2009-2021
Saitama Prefecture
2015-2021
Osaka University
2011-2016
Japan Atomic Energy Agency
2015
Princeton Plasma Physics Laboratory
2015
Nagoya University
1999-2011
Abstract One of the major reasons for wide epidemicity tuberculosis and necessity extensive chemotherapeutic regimens is that causative agent, Mycobacterium , has an ability to become dormant. Therefore, new lead compounds are anti‐bacterial against M. in both active dormant states urgently needed. Marine sponge diterpene alkaloids, agelasines B, C, D, from Indonesian marine genus Agelas were rediscovered as anti‐dormant‐mycobacterial substances. Based on concept transformants...
The breakdown of alumina rf windows is mostly caused by multipactor, as well material defects and contamination. Since multipator induces localized surface heating, leading to melting, it necessary observe secondary electron emission (SEE) coefficients ceramics under high temperature conditions. SEE commercial sapphire were measured a scanning microscopy (SEM) with single short-pulsed beam (100 pA, 1 ms) at room 650degC. Additive materials used for sintering alumina, such SiO <sub...
Previous phytochemical investigations have revealed the presence of a variety compounds such as pyrrolidine derivatives, flavonoids, and megastigmanes in Egyptian plants. Onopordum alexandrinum has been traditionally used by natives for treatment skin cancers leprosy. In this paper isolation four new sesquiterpene–amino acid conjugates, onopornoids A–D (1–4), i.e., three elemanes one germacrane, acylated flavonoid glucoside (5) along with nine known (6–14) from whole aerial parts title plant...
Design techniques for the vacuum insulation have been developed in order to realize a reliable voltage holding capability of multi-aperture multi-grid (MAMuG) accelerators fusion application. In this method, nested multi-stage configuration MAMuG accelerator can be uniquely designed satisfy target within given boundary conditions. The evaluation capabilities each acceleration stages was based on previous experimental results about area effect and effect. Since found extension by total facing...
In order to realize negative ion sources and accelerators be applicable International Thermonuclear Experimental Reactor JT-60 Super Advanced, a large cesium (Cs)-seeded source multi-aperture multi-stage electric acceleration have been developed at Japan Atomic Energy Agency (JAEA). Long pulse production of the beams independently carried out. The long high current has achieved 100 s beam 15 A by modifying source. duration time is increased three times longer than that before modification....
Chemical conversion of the extract natural resources is a very attractive way to expand chemical space discover bioactive compounds. In order search for new medicines treat parasitic diseases that cause high morbidity and mortality in affected countries world, ethyl acetate from rhizome Alpinia galanga (L.) has been chemically converted by epoxidation using dioxirane generated situ. The biological activity (CCE) A. significantly increased against Leishmania major up 82.6 ± 6.2 % at 25 μg/mL...
The potent antimycobacterial activity of (±)-platencin is reported. Complete inhibition Mycobacterium smegmatis growth was observed at MICs 0.5 μg mL−1 and 0.3 under aerobic hypoxic conditions, respectively. Notably, the compound exhibited bacteriostatic activities towards tuberculosis H37Rv (MIC = 2 mL−1), multi-drug-resistant M. 1 extensively drug-resistant mL−1). An overexpression study transformants revealed that platencin selectively targeted Mt-KasB modestly inhibited Mt-KasA Mt-FabH.
For the realization of ITER neutral beam (NB) system, a method for achieving acceleration voltage 1 MV vacuum insulated source (VIBS) has been developed. Additionally, design basis insulation also developed by integrating previous empirical scaling holding capability plane and coaxial electrodes with new corner region where locally-concentrated electric field is generated. The clarified that product obtained analysis in vessel was much higher than allowable level. Therefore, order to improve...
Three new flavonoid glycosides named isolinariins C, D and E (1-3), two known (4, 5) three flavonoids (6-8) were isolated from the whole plant of Linaria japonica. The structures these compounds determined mainly by spectroscopic analyses. bioactivities evaluated for their inhibitory activities against human cell line A549, collagenase, advanced glycation end product (AGE) formation. Among compounds, (1, 2 3) showed inhibition toward AGE formation (IC50 values 34.8, 35.0 19.5 µM,...
This paper describes the dependence of charging characteristics on electric field distribution alumina (Al/sub 2/O/sub 3/) surface as affected by triple junction in vacuum. For HV electrical insulation design vacuum interrupter, flashover is very important problem to be solved. Attention should paid fact that dielectric are strongly influenced emission electrons from and accumulated charges surface. In order clarify mechanism, we measured for various types junctions. particular, focused...
The objective of this paper is to research the charge distribution characteristics on inner surface a bottle type insulator depending shape shield ring, which used mitigate high electric field near triple junction. was sandwiched between upper and lower parallel electrodes. These electrodes were equipped with ring inside insulator. distributions measured over whole area cylindrical by an electrostatic probe after ramped dc voltage application. We investigated varying rings. As result, we...
The Asteraceae family is a promising source of bioactive compounds, such as the famous plants Tanacetum cinerariifolium (pyrethrin) and Artemisia annua (artemisinin). As result our series phytochemical studies subtropical plants, two novel sesquiterpenes, named crossoseamines A B in this study (1 2, respectively), one undescribed coumarin-glucoside (3), eighteen known compounds (4-21) were isolated from aerial part Crossostephium chinense (Asteraceae). structures elucidated by spectroscopic...
An investigation into the methanol extracts obtained from stems of Dodonaea viscosa led to isolation one nor-clerodane diterpene (1) and two labdane diterpenes (2, 3), as well 17 known compounds (4–20). The structures these were elucidated based on chemical spectral evidence. stereochemical structure was confirmed via its circular dichroism spectrum calculated electronic spectrum. Isolated evaluated for their inhibitory effects collagenase tyrosinase. Since...
Cadaba rotundifolia (Forssk.) (family: Capparaceae; common name: Qadab) is one of four species that grow in the Red Sea costal region Kingdom Saudi Arabia. The roots and leaves C. traditionally used to treat tumors abscesses Sudan. A previous phytochemical study yielded a quaternary alkaloid, but no report on chemical constituents aerial parts growing Arabia has been issued so far. Oxidative stress advanced glycation end products (AGEs) are thought as causal factors many degenerative...