A5017537703- Celiac Disease Research and Management
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Tryptophan and brain disorders
- Diabetes and associated disorders
- Food Allergy and Anaphylaxis Research
- SARS-CoV-2 and COVID-19 Research
- Digestive system and related health
- Indoor Air Quality and Microbial Exposure
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Multiple Sclerosis Research Studies
- Transgenic Plants and Applications
- Monoclonal and Polyclonal Antibodies Research
- Immunotoxicology and immune responses
- Atherosclerosis and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Lupus Erythematosus Research
- Microscopic Colitis
- Eosinophilic Esophagitis
- Gut microbiota and health
- Air Quality and Health Impacts
- Systemic Sclerosis and Related Diseases
- Occupational exposure and asthma
- Vitamin C and Antioxidants Research
Immunosciences Lab (United States)
2016-2025
CytRx (United States)
2013-2024
Phoenix (United States)
2013-2024
Ferdowsi University of Mashhad
2024
L'Alliance Boviteq
2024
Loma Linda University
2015-2022
Deakin University
2020
Xenobe Research Institute
2019
Lincoln College
2018
Harvard University
2017
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, molecular mimicry COVID-19 viral proteins tissues could be the cause. applied both monoclonal anti-SARS-Cov-2 (spike protein, nucleoprotein) rabbit polyclonal (envelope membrane protein) 55 different antigens. found that SARS-CoV-2 had reactions with 28 out of representing a diversity groups included barrier proteins, gastrointestinal, thyroid neural tissues, more....
Abstract COVID-19 shares the feature of autoantibody production with systemic autoimmune diseases. In order to understand role these immune globulins in pathogenesis disease, it is important explore spectra. Here we show, by a cross-sectional study 246 individuals, that autoantibodies targeting G protein-coupled receptors (GPCR) and RAS-related molecules associate clinical severity COVID-19. Patients moderate severe disease are characterized higher levels than healthy controls those mild...
Millions of children are exposed to concentrations air pollutants, including fine particulate matter (PM2.5 ), above safety standards. In the Mexico City Metropolitan Area (MCMA) megacity, show an early brain imbalance in oxidative stress
Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) severity due to immunosenescence and certain age-dependent medical conditions (e.g., obesity, cardiovascular disorder, chronic respiratory disease). However, despite well-known influence of age on autoantibody biology in health disease, its impact developing severe COVID-19 remains poorly explored. Here, we performed cross-sectional study autoantibodies directed against 58 targets associated with autoimmune diseases...
Persistent infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), reactivation of dormant viruses, and immune-oxidative responses are involved in long COVID.
Gut luminal dysbiosis and pathobiosis result in compositional biodiversified alterations the microbial host co-metabolites. The primary mechanism of bacterial evolution is horizontal gene transfer (HGT), acquisition new traits can be achieved through exchange mobile genetic elements (MGEs). Introducing genetically engineered microbes (GEMs) might break harmonized balance intestinal compartment. present objectives are: 1. To reveal role played by GEMs’ transfers changing landscape enteric...
Similar to many complex autoimmune diseases, genetic and environmental factors including diet, infection xenobiotics play a critical role in the development of autism. In this study, we postulated that infectious agent antigens such as streptokinase, dietary peptides (gliadin casein) ethyl mercury (xenobiotic) bind different lymphocyte receptors tissue enzyme (DPP IV or CD26). We assessed hypothesis first by measuring IgG, IgM IgA antibodies against CD26, CD69, streptokinase (SK), gliadin...
The mechanisms behind autoimmune reaction to nervous system antigens in autism are not understood. We assessed the reactivity of sera from 50 patients and healthy controls specific peptides gliadin cerebellum. A significant percentage showed elevations antibodies against cerebellar simultaneously. For examining cross-reaction between dietary proteins antigens, were prepared rabbits, binding rabbit anti-gliadin, anti-cerebellar peptides, anti-MBP, anti-milk, anti-egg, anti-soy anti-corn...
Currently, studies have shown that genetic predisposition accounts for approximately thirty percent of all autoimmune diseases.The rest, 70 percent, are due to environmental factors, including toxic chemicals, dietary components, gut dysbiosis, and infections (Figure 1).Autoimmune disorder symptoms initially nonspecific include malaise fatigue, low-grade fevers, aches, pains.Due this vagueness, patients frequently diagnosed with an disease after they become weak unable function normally,...
COVID-19 is a heterogenous disease resulting in long-term sequela predisposed individuals. It not uncommon that recovering patients endure non-respiratory ill-defined manifestations, including anosmia, and neurological cognitive deficit persisting beyond recovery-a constellation of conditions are grouped under the umbrella syndrome. Association between autoimmune responses individuals was shown several studies.To investigate against neuronal CNS autoantigens SARS-CoV-2-infected patients, we...
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is associated with increased levels of autoantibodies targeting immunological proteins such as cytokines and chemokines. Reports further indicate that COVID‐19 patients may develop a broad spectrum autoimmune diseases due to reasons not fully understood. Even so, the landscape induced by SARS‐CoV‐2 remains uncharted territory. To gain more insight, we carried out comprehensive assessment known be linked...
After exposure to many toxic chemicals, NK function can be decreased significantly. Weeks or months later, natural killer (NK) rebound normal levels in some and suppressed for prolonged periods of time other patients.In view this, we decided study the effect buffered vitamin C on NK, T B cell patients who had been exposed chemicals. first blood draw, 55 immediately ingested granulated water at a dosage 60 mg/Kg body weight. Exactly 24 hours was again drawn follow-up function. Vitamin high...
Gut luminal dysbiosis and pathobiosis result in compositional biodiversify alterations the microbial host co-metabolites. The main mechanism of bacterial evolution is horizontal gene transfer (HGT) acquisition new traits can be achieved through mobile genetic element (MGEs) exchange. Introducing genetically engineered microbes (GEMs) might break harmonized balance intestinal compartment. present objectives are: 1. To reveal role played by GEMs' transfers changing landscape enteric...
Mycoplasma fermentans and other species are colonizers of human mucosal surfaces may be associated with immunodeficiency virus infection. While many infectious agents have been described in different percentages patients Chronic Fatigue Syndrome (CFS), little is known about the prevalence mycoplasmas especially M. CFS patients. A polymerase chain reaction (PCR)-based assay was used to detect genus genomes peripheral blood mononuclear cells (PBMC) Blood collected from 100 50 control subjects....