A5026855073- Neuropeptides and Animal Physiology
- Dental Implant Techniques and Outcomes
- Oral microbiology and periodontitis research
- Pain Mechanisms and Treatments
- Periodontal Regeneration and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Ion channel regulation and function
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Forensic Anthropology and Bioarchaeology Studies
- Tissue Engineering and Regenerative Medicine
- Bone Metabolism and Diseases
- Endodontics and Root Canal Treatments
- Neuroendocrine regulation and behavior
- Adenosine and Purinergic Signaling
- Pharmacological Effects and Assays
- Dental Radiography and Imaging
- Oral and gingival health research
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Bone and Dental Protein Studies
- Neuroscience of respiration and sleep
- Pharmacological Receptor Mechanisms and Effects
- Nicotinic Acetylcholine Receptors Study
Universidad Complutense de Madrid
2024
The University of Adelaide
2003-2018
Australian Dental Association
2007-2013
Background and Objective: The origin of cells in the mature periodontium, location their progenitors, are still unknown. It is also unknown whether inflammation influences number distribution these within periodontium. Molecules such as STRO‐1, CD146 CD44 have been identified on a variety mesenchymal stem cells. aim this study was to identify localize putative diseased healthy human periodontal ligament using cell‐surface markers for Material Methods: Healthy periodontitis‐affected teeth...
Mesenchymal stem cells (MSC) have been considered as a potential therapy for the treatment of periodontal defects arising from periodontitis. However, issues surrounding their accessibility and proliferation in culture significantly limit ability to be used mainstream approach. It is therefore important that alternative, easily accessible, safe populations identified. Controlled induction induced pluripotent (iPSC) into MSC-like emerging an attractive source obtaining large regenerative...
Background and Objective The complex microenvironment of the periodontal wound creates many challenges associated with multitissue regeneration lesions. Recent characterization mesenchymal stem cell‐like populations residing in ligament tissues has shown that these cells exhibit features postnatal cells. Despite advances, a lack consistency design preclinical studies limited study allogeneic transplantation applications restricted our understanding their clinical utility treatment disease....
Cantley MD, Bartold PM, Marino V, Fairlie DP, Le GT, Lucke AJ, Haynes DR. Histone deacetylase inhibitors and periodontal bone loss. J Periodont Res 2011; 46: 697–703. © 2011 John Wiley & Sons A/S Background Objective: Bone loss caused by enhanced osteoclast activity is a significant feature of periodontitis. (HDACi) can suppress osteoclast‐mediated in vitro vivo . This study investigated whether HDACi experimental Material methods: Experimental periodontitis was induced mice oral...
Periodontitis is an infective disease caused predominantly by gram-negative anerobes. The host inflammatory response to these bacteria causes alveolar bone loss, which characterizes periodontitis. Omega-3 polyunsaturated fatty acids have recognized anti-inflammatory effects; their oxygenated derivatives are key mediators in reducing inflammation. In this study we tested the hypothesis that dietary supplementation with tuna fish oil rich n-3 acid, docosahexaenoic would reduce loss mice...
Objectives: To assess the relationship between smooth and roughened implant surfaces of straight narrow configurations with respect to microdamage bone surface during placement dental implants Materials methods: Straight tapered, rough Nobel Biocare were placed into sheep mandibles. Microdamage within adjacent was quantitated using a semi-automated digitized histomorphometric method. Results: Independent type, microdamage, microcracks, cross-hatch damage diffuse significantly higher close...
Mesenchymal stromal cell-like populations have been derived from mouse-induced pluripotent stem cells (miPSC-MSC) with the capability for tissue regeneration. In this study, murine iPSC underwent differentiation towards an MSC-like immunophenotype. Stable miPSC-MSC cultures expressed MSC-associated markers, CD73, CD105, and Sca-1, but lacked expression of pluripotency marker, SSEA1, hematopoietic CD34 CD45. Functionally, exhibited potential trilineage into osteoblasts, adipocytes,...
Live-animal micro-computed tomography is a new and promising technique that can be used to quantify changes in bone volume for periodontal disease models. The major aim of this study was develop the methodology live-animal determine effect novel secretory phospholipase A2 inhibitor on alveolar loss.Periodontitis induced mice by oral infection with Porphyromonas gingivalis over period 13 wk, scans were taken at different time-points progression. This enabled conclusions made as when treatment...
Abstract In rodent models of inflammatory arthritis, bone erosion has been non‐invasively assessed by micro‐computed tomography (micro‐ CT ). However, non‐invasive assessments paw swelling (oedema) are still based on clinical grading visual evaluation, or measurements callipers, not always reliable for the tiny mouse paws. The aim this work was to demonstrate a novel straightforward 3 D micro‐ analysis protocol capable quantifying only joint erosion, but also soft tissue swelling, from same...
Abstract Background : This study evaluated the attachment of human periodontal ligament (HPDL) and gingival (HG) fibroblasts onto commercially available barrier membranes coated with plateletrich plasma (PRP). Methods Gore‐Tex® Regenerative Membrane (GTN1), Inion GTR® Biodegradable system (INION), Gore‐Resolut XT membrane (GTRX) were studied. The pre‐wetted phosphate buffered saline before exposure to PRP for two hours. HPDL or then seeded incubated in culture medium 24 samples fixed...
γ-aminobutyric-acid-containing neurons and GABA B receptors have been identified in human dental pulp; however, their significance pulpal physiology is unclear. The purpose of this study was to determine whether pre-synaptic GABAergic heteroreceptors influence the release noradrenaline (NA). Segments vital pulp were incubated [ 3 H]NA (0.6 μM) superfused with Krebs solution. GABA, a receptor agonist (baclofen), A antagonists [bicuculline (+)-(S)-5, 5-dimethylmorpholinyl-2-acetic acid (Sch...
Cultures of stromal cells from pregnant mouse uterus, and an FL cell line derived human amnion, displayed significant capacities to O-methylate noradrenaline. O-methylation was inhibited in the by uptake1-inhibitors, uptake2 inhibitors. These findings are discussed terms distribution possible functional importance catecholamine metabolising systems female reproductive system.