BACKGROUND AND IMPORTANCE: Anterior cerebral artery aneurysms requiring bypass are rare; thus, the literature regarding subsequent pathology related to procedure is severely lacking. Hence, there no consensus management strategy. The progressive enlargement of de novo para-anastomotic aneurysm carries a higher rupture risk this abnormal vessel. peculiar location, vascular territory, and small corridor interhemispheric fissure pose challenges its management. CLINICAL PRESENTATION: We present...

Moyamoya disease (MMD) is a unique progressive steno-occlusive of the distal ends bilateral internal arteries and their proximal branches. The difference in clinical symptoms between adult children MMD patients has been well recognized. In this study, we sought to investigate phenomenon through histopathological study. Fifty-one underwent surgical procedures for treatment standard indications at Kyoto University Hospital. Fifty-nine specimens MCA were obtained from during procedures. Five...

Recent research has demonstrated that mesenchymal stem cells (MSCs) potentially benefit and enhance coronavirus disease (COVID-19) recovery. This occurs via a mechanism promotes viral clearance by phagocytes macrophages. action through the innate (increase in IL-10 production decrease TNF-α IL-12 production) adaptive immune system (decrease IL-17 production, promote regulatory T cell proliferation inhibit effectors proliferation). MSCs are expected to act as an anti-inflammatory...

Abstract The use of human induced pluripotent stem cells (hiPSCs) eliminates the ethical issues associated with fetal or embryonic materials, thus allowing progress in cell therapy research for ischemic stroke. Strict regulation development requires xeno‐free condition to eliminate clinical complications. Maintenance hiPSCs feeder‐free presents a higher degree spontaneous differentiation comparison conventional cultures. Therefore, derivation might be not ideal developing transplantable...

Introduction: Meningitis is the most severe and dangerous complication of tuberculosis, can be fatal if not treated adequately. Acute hydrocephalus often accompanied by tuberculous meningitis. This study aims to assess prognostic factors in adult patients with meningitis hydrocephalus.
 Methods: The was conducted retrospectively collecting data from medical records TB Patient were collected analyzed using multiple logistic regression obtain significant factors.
 Result: Fifty-four...

Abstract Oligodendrocytes (OLs) show heterogeneous properties that depend on their location in the central nervous system (CNS). In this regard, investigation of oligodendrocyte precursor cells (OPCs) derived from human pluripotent stem (hPSCs) should be reconsidered, particularly cases brain‐predominant disorders for which brain‐derived OPCs are more appropriate than spinal cord‐derived OPCs. Furthermore, animal‐derived components responsible culture variability derivation and complicate...

Clinical features of high risk brain arteriovenous malformations (BAVMs) are well characterized. However, pathological evidences about the differences that possessed by patients still lacking. We reviewed archived routine hematoxylin-eosin specimens from a total 54 surgical treated BAVMs. The histopathological in nidus were semi-quantitatively analyzed. obtained BAVMs between several clinical features. Among analyzed features, significant observed degree venous enlargement and intimal...

The presence of pneumonia in patients with traumatic brain injury (TBI) is associated high fatality and poor outcomes. Patients severe TBI are often admitted to the intensive care unit, which utilization APACHE II score commonly used predict mortality risk. Therefore, we aimed evaluate association between incidence ventilator-associated (VAP) TBI. This was a retrospective study. A total 32 who were unit at Dr. Hasan Sadikin Hospital from January 1, 2018 – December 31, 2019, investigated this...

Abstract Background Over the last decade, since clinical trials examining targeted therapeutics for gliomas have failed to demonstrate a meaningful increase in survival, emphasis has recently been switched toward innovative techniques modulating immune response against tumors and their microenvironments (TME). Cancerous cells eleven hallmarks which make it distinct from normal ones, among is evasion. Immune evasion glioblastoma helps evade various treatment modalities. Summary Glioblastoma’s...

Gliomas are the most prevalent type of primary brain tumors. Clarifying correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand (PD-L1) L-type amino acid transporter (LAT-1) with respect to overall survival in patients. Immunohistochemistry (IHC) results from 25 samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens diagnosed as grade II,...

Objective Diffuse astrocytic tumour (DAT) is a diffuse infiltrative astrocytoma accompanied by molecular parameters such as the presence or absence of isocitrate dehydrogenase (IDH) gene mutations. Ki-67 marker for DAT proliferation, while programmed death ligand 1 (PD-L1) indicates an immune evasion mechanism. This study aimed to analyze correlation among mutant IDH1 R132H, Ki-67, and PD-L1 immunoexpression in DAT. Methods A cross-sectional was carried out on 30 paraffin blocks cases....

Background: Dura mater is a special tissue that fulfills critical function in brain anatomy and physiology. This contains numerous cells, stem growth factors. research investigates the protein interaction contributing to dura healing process. Methods: We use available analysis software perform protein-protein (PPI) (http://gpsprot.org/index.php). GPS Protein an interactive platform for visualizing human by integrating HIPPIE CORUM databases. excluded HIV-1 proteomic RNAi databases, instead...

Abstract Objective: The IDH1 mutation status is one of the main factors indicated prognosis patients with astrocytic malignancies; yet, targeted sequencing not readily available in countries limited resources. We aimed to analyze association between examination and overall survival rates diffuse tumor patients. Methods: This retrospective cohort multicenter study included 327 patients, January 2017 – December 2022. immunohistochemistry or PCR data MGMT status, WHO classification, Karnofsky...

Background: It is known that eye enucleation causes various morphological and functional alterations in the central nervous system (CNS). The purpose of this study was to examine sub-chronic effects monocular on distribution calcium binding proteins calbindin D28k (CB) parvalbumin (PV) as well glial fibrillary acidic protein (GFAP) immunoreactivity superior colliculus (SC) Wistar rats.Materials Methods: Thirty young adult (8 weeks) male rats from SLC (Shizuoka, Japan), weighing 200-250...

Introduction: Glioblastoma is the deadliest malignant brain tumors in adults. The main challenges treating glioblastoma are its resistance to chemo-radiotherapy, poor outcome and low survival rate. World Health Organization (WHO) 2016 classification identifies two types of by mutational status isocitrate dehydrogenase (IDH); since our national insurance experiences budget-limitation, we could not freely apply it institutions. We aims find prevalence glioblastoma-not otherwise specified (NOS)...

BACKGROUND: Coronavirus (CoV) disease (COVID-19) has become a global health pandemic by early 2020; it pushed the health-care system to its limit. From initial estimates, 15% of COVID-19 patients caused severe acute respiratory CoV 2 syndrome present with symptoms and requires hospitalization or even intensive care. There is no specific treatment against COVID-19, particularly for those symptoms. Desperation driven clinicians try an alternative therapies little no-evidence previously....

BACKGROUND: Moyamoya disease (MMD) is a peculiar disease, characterized by progressive steno-occlusion of the distal ends bilateral internal carotid arteries and their proximal branches. Numerous studies MMD investigated as singular pathway, thus overlooked complexity pathobiology.
 AIM: In this study, we sought to investigate gene expression in involved reveal novel mechanism MMD.
 MATERIALS AND METHODS: Eight middle cerebral artery (MCA) specimens were obtained from six patients...