A5105930202- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Global Cancer Incidence and Screening
- Air Quality and Health Impacts
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Minimally Invasive Surgical Techniques
- Surgical Simulation and Training
- Heavy Metal Exposure and Toxicity
- Colorectal Cancer Surgical Treatments
- Economic and Financial Impacts of Cancer
- Radiomics and Machine Learning in Medical Imaging
- Healthcare professionals’ stress and burnout
- Cancer, Lipids, and Metabolism
- COVID-19 and healthcare impacts
- MRI in cancer diagnosis
- Urinary and Genital Oncology Studies
- Extracellular vesicles in disease
- Healthcare Policy and Management
- Ultrasound Imaging and Elastography
- Statistical Methods in Clinical Trials
- Radiation Dose and Imaging
- Ultrasound and Hyperthermia Applications
- Circular RNAs in diseases
- Toxic Organic Pollutants Impact
Duke University
2023-2025
University of Illinois Chicago
2016-2025
Duke Medical Center
2016-2025
Illinois College
2020
Memorial Sloan Kettering Cancer Center
2019
Accreditation Council for Graduate Medical Education
2019
University of Illinois Urbana-Champaign
2019
University of Illinois Hospital & Health Sciences System
2017
Rush University Medical Center
2012
Background Healthcare professionals (HCPs) on the front lines against COVID-19 may face increased workload and stress. Understanding HCPs' risk for burnout is critical to supporting HCPs maintaining quality of healthcare during pandemic. Methods To assess exposure, perceptions, workload, possible pandemic we conducted a cross-sectional survey. The main outcomes measures were self-assessment burnout, indicated by single item measure emotional exhaustion, other experiences attitudes associated...
Background: Healthcare professionals (HCPs) on the front lines against COVID-19 may face increased workload, and stress. Understanding HCPs risk for burnout is critical to supporting maintaining quality of healthcare during pandemic. Methods: To assess exposure, perceptions, possible pandemic we conducted a cross-sectional survey. The main outcomes measures were self-assessment other experiences attitudes associated with working Findings: A total 2,707 from 60 countries participated in this...
We compared intraoperative and perioperative outcomes between extraperitoneal transperitoneal radical prostatectomy performed using a "purpose-designed" single port robotic platform.A total of 98 patients underwent the da Vinci SP® system with (group I, 52) vs II, 46) approach. Demographics data including postoperative recovery were recorded 2 groups.Groups similar in terms demographics prostate cancer risk category. Mean operative time (201±37.5 248.2±42.3 minutes, p <0.00001) as well...
Background: Healthcare professionals (HCPs) on the front lines against COVID-19 may face increased workload, and stress. Understanding HCPs' risk for burnout is critical to supporting HCPs maintaining quality of healthcare during pandemic.Methods: To assess exposure, perceptions, possible pandemic we conducted a cross-sectional survey. The main outcomes measures were self-assessment other experiences attitudes associated with working pandemic.Findings: A total 2,707 from 60 countries...
Objective: To report early institutional experience with the single-port robotic platform and compare perioperative outcomes between robot-assisted partial nephrectomies (SP-RAPN) multiport (MP-RAPN) when utilizing a retroperitoneal approach. Methods: A retrospective chart review of patients who underwent SP-RAPN or MP-RAPN at our institution November 1, 2013 May 30, 2021 was performed. Surgical platforms were compared through univariate analysis using Kruskal–Wallis test for continuous...
262 Background: Stockholm3 is a multiparametric blood test incorporating germline risk, proteins and clinical data which improves prostate cancer (PC) risk stratification compared to PSA, however no validation exists in an ethnically diverse population. Methods: SEPTA prospective trial (NCT04583072) aimed validate cohort of men referred for biopsy at 17 North American sites from 2019 2023 (supplemented with bio-banked specimens 2008-2020). The had two prespecified primary aims when comparing...
410 Background: Inflammasomes are multiprotein complexes that regulate inflammation-associated signaling pathways. Although inflammation plays a crucial role in cancer cell proliferation, the specific of inflammasomes prostate (PCa) remains underexplored. This study aims to elucidate expression inflammasome-related genes PCa and assess their association with clinical outcomes. Methods: De-identified transcriptome data from cohort 52,266 radical prostatectomy (RP) samples tested (2016-2024)...
The purpose of this study was to compare performance Stockholm3 in an external validation with commonly used prostate cancer biomarkers and risk calculators. SEPTA a multicenter trial validating racially/ethnically diverse population men meeting local care guidelines for biopsy (2019-2023). In total, 2115 (98%) complete data calculators were included. primary outcome detection Grade Group ≥ 2 (GG 2) cancer. Predictors included Stockholm3, free/total PSA ratio, density, European Randomized...
The incidence of infectious complications after transrectal ultrasound guided prostate needle biopsy is rising. We sought to identify the and predictors infection in a large cohort men undergoing who receive targeted prophylaxis.We retrospectively reviewed records 5,214 consecutive patients underwent from January 2013 December 2014 at UroPartners, urology group comprising 28 clinics metropolitan Chicago. At 1 microbiology laboratory all swabs were processed, presence fluoroquinolone...
The Genomic Prostate Score (GPS), performed on biopsy tissue, predicts adverse outcome in prostate cancer (PCa) and has shown promise for improving patient selection active surveillance (AS). However, its impact treatment choice high-risk populations of African Americans is largely unknown and, general, the effect GPS this difficult decision not been evaluated randomized trials.
In the prostate-specific antigen (PSA) screening era, approximately 15% of US men still present with clinically high-risk prostate cancer (PC). However, PC may be downgraded/downstaged at radical prostatectomy (RP), making additional therapy unnecessary. The authors tested oncologic outcomes in disease stratified on RP pathology.A total 611 (PSA level > 20 ng/mL, biopsy Gleason sum [bGS] ≥ 8, or clinical classification T3) underwent and pelvic lymphadenectomy between 1998 2011. Outcomes...
BACKGROUND: Abnormal methylation of urinary TWIST1 and NID2 conferred high sensitivity specificity for the detection urothelial carcinoma. OBJECTIVE: We examine performance urine-based TWIST1/NID2 assay with addition urine cytology urotheli al MATERIALS AND METHODS: A prospective multi-institutional study was conducted to assess a patients hematuria or under surveillance non-muscle invasive bladder cancer (NMIBC). All underwent cystoscopy, assay, cytology. Receiver operator characteristic...