A5003515248- Cardiac electrophysiology and arrhythmias
- Advanced Radiotherapy Techniques
- Numerical methods in engineering
- Prostate Cancer Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Cardiovascular Function and Risk Factors
- Advanced Numerical Methods in Computational Mathematics
- Fluid Dynamics Simulations and Interactions
- Ion channel regulation and function
- Advanced X-ray and CT Imaging
- Tissue Engineering and Regenerative Medicine
- Medical Imaging Techniques and Applications
- Elasticity and Material Modeling
- Dam Engineering and Safety
- Cardiomyopathy and Myosin Studies
- Cardiac Arrhythmias and Treatments
- Model Reduction and Neural Networks
- ECG Monitoring and Analysis
- Advanced MRI Techniques and Applications
- Radiation Therapy and Dosimetry
- Cardiovascular Effects of Exercise
- Prostate Cancer Treatment and Research
- Computational Fluid Dynamics and Aerodynamics
- 3D Printing in Biomedical Research
- High voltage insulation and dielectric phenomena
University College London
2022-2024
Instituto de Investigación Sanitaria Aragón
2019-2023
Universidad de Zaragoza
2019-2023
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2020-2023
Instituto de Salud Carlos III
2023
Institute of Engineering
2020
Laboratoire de Traitement de l'Information Médicale
2016-2018
Université de Bretagne Occidentale
2018
Inserm
2017
Centre Hospitalier Régional Universitaire de Brest
2017
Engineered heart tissues (EHTs) built from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) showed promising results for cardiac function restoration following myocardial infarction. Nevertheless, iPSC-CMs have longer action potential and lower cell-to-cell coupling than adult-like CMs. These immature electrophysiological properties favor arrhythmias due to the generation of gradients when hiPSC-CMs are injected in tissue. Culturing on three-dimensional (3D) scaffolds...
This research explored a novel explicit total Lagrangian Fragile Points Method (FPM) for finite deformation of hyperelastic materials. In contrast to mesh-based methods, where mesh distortion may pose numerical challenges, meshless methods are more suitable large modelling since they use enriched shape functions the approximation displacements. However, this comes at expense extra computational overhead and higher-order quadrature is required obtain accurate results. work, method FPM was...
The monodomain model is widely used in in-silico cardiology to describe excitation propagation the myocardium. Frequently, operator splitting decouple stiff reaction term and diffusion so that they can be solved separately. Commonly, implicitly with a large time step while by using an explicit method adaptive stepping. In this work, we propose fully for solution of decoupled model. contrast semi-implicit methods, methods present lower memory footprint higher scalability. However, such are...
Hyperactivity of the parasympathetic nervous system has been linked to development paroxysmal atrial fibrillation (AF). The neurotransmitter acetylcholine (ACh) causes a reduction in action potential (AP) duration (APD) and an increase resting membrane (RMP), both which contribute enhance risk for reentry. Research suggests that small-conductance calcium activated potassium (SK) channels may be effective target treating AF. Therapies targeting autonomic system, either alone or combination...
We present a new hybrid edge and region-based parametric deformable model, or active surface, for prostate volume segmentation in transrectal ultrasound (TRUS) images.Our contribution is threefold. First, we develop detector derived from the radial bas-relief approach, allowing better scalar detection low contrast configurations. Second, combine an edge-based force proposed with driven by Bhattacharyya gradient flow adapted to case of surfaces. Finally, quasi-automatic initialization...
Abstract Cardiac tissue slices preserve the heterogeneous structure and multicellularity of myocardium allow its functional characterization. However, access to human ventricular samples is scarce. We aim demonstrate that from small transmural core biopsies collected living donors during routine cardiac surgery structural properties larger myocardial specimens, allowing accurate electrophysiological In pigs, we compared left with blocks same region. humans, analyzed papillary muscles donors....
Biofabrication of human tissues has seen a meteoric growth triggered by recent technical advancements such as induced pluripotent stem cells (hiPSCs) and additive manufacturing. However, generation cardiac tissue is still hampered lack adequate mechanical properties crucially the often unpredictable post-fabrication evolution biological components. In this study we employ melt electrowriting (MEW) hiPSC-derived to generate fibre-reinforced minitissues. These are thoroughly characterized in...
Rule-based methods are commonly used to estimate the arrangement of myocardial fibers by solving Laplace problem with appropriate Dirichlet boundary conditions. Existing algorithms using Finite Element Method (FEM) solve Laplace-Dirichlet problem. However, meshless under development for cardiac electrophysiology simulation. The objective this work is propose a rule based method determination fiber without requiring mesh discretization as it required FEM.The proposed employs Fragile Points...
We present the Cell-based Maximum Entropy (CME) approximants in E3 space by constructing smooth approximation distance function to polyhedral surfaces. CME is a meshfree method combining properties of and compact support element-based interpolants. The evaluated problems large strain elastodynamics for three-dimensional (3D) continua using well-established Meshless Total Lagrangian Explicit Dynamics (MTLED) method. accuracy efficiency assessed several numerical examples terms computational...
Multi-scale cardiac electrophysiological modeling involves high computational load due to the inherent complexity as well limitations of employed numerical methods (e.g., Finite Element Method -FEM).This study investigates use Meshless Local Petrov-Galerkin Mixed Collocation (MLPG-MC) method simulate electrophysiology.MLPG-MC is a truly meshless where both unknown function and its gradient are interpolated using nodal collocation.A 3 cm × human ventricular tissue was simulated based on...
The autonomic nervous system (ANS) plays an essential role in the generation and maintenance of cardiac arrhythmias. ANS can be divided into its extrinsic intrinsic components, with latter being organized epicardial neural network interconnecting axons clusters ganglia called ganglionated plexi (GPs). GP ablation has been associated a decreased risk atrial fibrillation (AF) recurrence, but accurate location GPs is required for to effective. Although stimulation triggers both sympathetic...
We present the meshfree mixed collocation method (MCM) for cardiac electrophysiology simulation. Capitalizing on property of MCM, we introduce an immersed grid approach automated generation node grids from medical image data. This allows us to avoid time-consuming mesh and processing that mesh-based methods like finite element (FEM) require. employ MCM solve monodomain model considering electrical propagation in 2D tissue sheets, 3D slabs, a realistic biventricular anatomy. demonstrate...
Prostate volume changes due to edema occurrence during transperineal permanent brachytherapy should be taken under consideration ensure optimal dose delivery.Available models, based on prostate observations, face several limitations.Therefore, patient-specific models need developed accurately account for the impact of edema.In this study we present a biomechanical model reproduce resolution patterns documented in literature.Using biphasic mixture theory and Finite Element analysis, proposed...
There is increasing evidence on the role of autonomic nervous system in pathogenesis atrial fibrillation. Interventions targeting modulation electrical activity have been shown to reduce incidence arrhythmias. Additionally, recent investigations proved that pharmacological therapies inhibiting small-conductance calcium-activated potassium (SK) channels are able lessen cholinergic effects atria. In this study we use computational modeling and simulation test individual combined SK channel...
Background: The purpose of this study was to develop a rapid, reliable, and efficient tool for three-dimensional (3D) dosimetry treatment planning post-treatment evaluation liver radioembolization with 90Y microspheres, using tissue-specific dose voxel kernels (DVKs) that can be used in everyday clinical practice. Materials Methods: Two DVKs were calculated through Monte Carlo (MC) simulations. the lungs generated, distribution compared direct MC A method developed produce 3D map by...
Multi-scale cardiac electrophysiological modeling involves high computational load due to the inherent complexity as well limitations of employed numerical methods (e.g., Finite Element Method - FEM). This study investigates use Meshless Local Petrov-Galerkin Mixed Collocation (MLPG-MC) method simulate electrophysiology. MLPG-MC is a truly meshless where both unknown function and its gradient are interpolated using nodal collocation. A 3 cm × human ventricular tissue was simulated based on...
State-of-art simulators of cardiac tissue electrophysiology are commonly based on the Finite Element Method (FEM).FEM is known to be a robust and accurate numerical method, but its accuracy highly depends quality mesh.Generating good-quality mesh may cumbersome time consuming for models with complex geometries, such as those representing anatomy human organs.This limitation restricts clinical application FEM.To overcome this challenge, we propose use meshfree Moving Kriging Mixed Collocation...