A5025810259- scientometrics and bibliometrics research
- Cardiac, Anesthesia and Surgical Outcomes
- Complementary and Alternative Medicine Studies
- Musculoskeletal pain and rehabilitation
- Burn Injury Management and Outcomes
- Academic Publishing and Open Access
- Health and Medical Research Impacts
- Immunotherapy and Immune Responses
- Health Sciences Research and Education
- Injury Epidemiology and Prevention
- Spine and Intervertebral Disc Pathology
- Hemodynamic Monitoring and Therapy
- Cancer Immunotherapy and Biomarkers
- Healthcare Policy and Management
- Innovations in Medical Education
- Cancer-related Molecular Pathways
- Spaceflight effects on biology
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Publishing and Scholarly Communication
- Space Exploration and Technology
- High Altitude and Hypoxia
- Artificial Intelligence in Healthcare and Education
- Monoclonal and Polyclonal Antibodies Research
- Reconstructive Surgery and Microvascular Techniques
University of California, Irvine
2015-2025
UC Irvine Health
2019-2024
Mayo Clinic
1993-2019
Ottawa Hospital
2019
Ottawa Hospital Research Institute
2019
Teesside University
2019
The University of Texas Health Science Center at Houston
2018
Mayo Clinic in Florida
2012-2017
Health and Safety Authority
2017
Health Information and Quality Authority
2017
While the immune microenvironment has been investigated in breast cancers, little is known about its role non-malignant tissues. Here we quantify and localize cellular components normal tissue lobules, with without visible infiltrates (lobulitis). Up to ten representative lobules each eleven samples were assessed for B cells (CD20), cytotoxic T (CD8), helper (CD4), dendritic (CD11c), leukocytes (CD45), monocytes/macrophages (CD68). Using digital image analysis, cell densities measured...
// Jiayin Shen 1 , Karson S. Putt 2 Daniel W. Visscher 3 Linda Murphy 4 Cynthia Cohen 5 Sunil Singhal 6 George Sandusky 7 Yang Feng 8 Dimiter Dimitrov and Philip Low 1,2 Department of Chemistry, Purdue University, West Lafayette, IN, USA Center for Drug Discovery, Laboratory Medicine Pathology, Mayo Clinic, Rochester, MN, Biochemistry Molecular Biology, Clinic College Medicine, Pathology Emory University Hospital, Atlanta, GA, Division Thoracic Surgery, Hospital the Pennsylvania School...
In a previous study of gene array data, the authors identified survivin as candidate marker aggressiveness in clear cell renal carcinoma (ccRCC). What remained question was whether expression at protein level is an independent predictor disease progression and cancer-specific survival.Between 1990 1994, 312 patients underwent nephrectomy for ccRCC Mayo Clinic Rochester had paraffin tissue available. The performed immunohistochemistry with antisurvivin antibody, quantitated by using...
Lung cancer is the number one cause of deaths in United States and globally. The advent targeted therapies has offered a new treatment paradigm for lung cancer, but currently validated emerging drugs are effective only small minority cancers, predominantly adenocarcinomas. Folate receptors can serve as targets attached to folate overexpressed many cancers.To determine frequency receptor overexpression cancers different cell types potential folate-linked therapy.High-density tissue...
Abstract Folate receptors (FR) may be of use for targeted delivery cytotoxic drugs in invasive urothelial carcinoma (iUC), which improved therapy is needed. FR expression and function iUC were explored the antitumor activity toxicity a folate-targeted vinblastine conjugate evaluated dogs with naturally occurring iUC, an excellent model human iUC. immunohistochemistry was carried out on normal dog bladder tissues together nuclear scintigraphy to monitor folate uptake. Dose escalation...
Recent surveys indicate that 48% of consumers actively use generative artificial intelligence (AI) for health-related inquiries. Despite widespread adoption and the potential to improve health care access, scant research examines performance AI chatbot responses regarding emergency advice.
Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of cytokines produced by activated macrophages (e.g., TNFα, IL-1, IL-6, IL-17, GM-CSF). However, no approved directly target this subset macrophages.First, we undertook to examine whether the folate receptor beta (FR-β) positive subpopulation macrophages, which marks in animal models rheumatoid arthritis, might constitute prominent population inflamed lesions humans. Next, utilized anti-FR-β...
Important questions for pediatric burn care specialists relate to the quality of life those children who survive most severe injuries. This study examines psychological adjustment 25 survived injuries > or = 80% total body surface area and impact such injury on families. Data were analyzed from recent assessment, with Child Behavior Checklist, Teacher Report Form, Piers-Harris Children's Self-Concept Scale, Parenting Stress Index, a parental questionnaire designed by authors. As group,...
The optimal retrieval of a literature search in biomedicine depends on the appropriate use Medical Subject Headings (MeSH), descriptors and keywords among authors indexers. We hypothesized that authors, investigators indexers four biomedical databases are not consistent their terminology Complementary Alternative Medicine (CAM). Based research question addressing validity spinal palpation for diagnosis neuromuscular dysfunction, we developed concepts with respective controlled vocabulary key...
Parents of pediatric patients with burns often perceive their children as troubled and having an increased number problem behaviors. This study examines the relationship between these behaviors parent's own emotional well-being. Mothers 38 burned completed three standardized questionnaires: Child Behavior Checklist, Parental Stress Index, Eight State Questionnaire. The population was further divided into untroubled by a Checklist total T score 60. were not significantly different from...
The aim of this study was to illustrate the contribution stakeholder engagement impact health technology assessment (HTA) using an Irish HTA a national public access defibrillation (PAD) program.In response draft legislation that proposed PAD program, Minister for Health requested Information and Quality Authority undertake inform design implementation program necessary underpinning legislation. outlined requiring widespread installation maintenance automatic external defibrillators in...