ZnO films grown by pulsed-laser deposition on c-plane Al2O3 substrates were annealed at temperatures up to 600 °C produce n-type carrier concentrations in the range 7.5×1015–1.5×1020 cm−3. After high-dose (3×1016 cm−2) Mn implantation and subsequent annealing °C, all show 2–5×1020 cm−3 room temperature hysteresis magnetization loops. The saturation coercivity of implanted single-phase both strong functions initial anneal temperature, suggesting that concentration alone cannot account for...

A study of single-dose digoxin kinetics was performed in 6 young and 7 elderly patients. The rate absorption, determined by the time to peak concentration after an oral dose, more rapid younger group. extent as measured comparison area under plasma concentration/time curve intravenous administration, similar both groups. Mean half-life longer individual values were variable absolute apparent volume distribution reduced older patients correlated inversely with age. When corrected for weight,...

The effects of oral and intravenous administration atenolol were studied in healthy volunteers. aseries single doses reduced an exercise tachycardia. After a 200‐mg dose, the effect on tachycardia was maximal at 3 hr declined linearly with time rate approximately 10% per 24 hr. peak plasma concentration occurred thereafter exponentially elimination half‐life 6.36 ± 0.55 hr: 43 3.9% dose excreted urine within 72 There correlation between reduction logarithm corresponding concentration....

Beta adrenoceptor–mediated responsiveness to isoproterenol was compared in young and old subjects using the production of cyclic adenosine monophosphate (cyclic AMP) by lymphocytes as an index. The mean log dose-response curve for elderly group displaced right maximum response less than that subjects. results corroborate evidence a decreased isoproterenol-induced increases heart rate raise possibility generalized decrease beta functions age. Clinical Pharmacology Therapeutics (1980) 27,...

ABSTRACT: In a survey of an institutional geriatric population 403 patients it was found that among 88 who were being maintained with digitalis, 31 had been receiving for at least year although currently there no evidence heart disease. A study conducted to ascertain whether or not necessary continue digitalis. Pertinent clinical and laboratory baseline data included serum digoxin levels creatinine clearance; the remainder determinations repeated three weeks seven after omission Baseline...

Abstract Forty one intensive care unit and 61 medical surgical ward registered nurses from two large urban teaching hospitals completed a stress questionnaire to examine factors, coping behaviors, recommendations for alleviating within the work environment. Stress variables were grouped into five clusters: (a) patient‐related, (b) environmental, (c) management‐related, (d) interpersonal, (e) knowledge skills. Multivariate analysis of variance demonstrated significant main effect, with...

The effects of strenuous exercise on lymphocyte beta‐adrenoceptor density and responsiveness in nine men were biphasic. There was an initial increase receptor density, seen immediately after exercise, with a subsequent decline to below pre‐exercise values. In parallel, maximum isoprenaline‐stimulated cyclic AMP production by lymphocytes greatly increased at the end decreased thereafter. increases may be functional significance represent response tissue demands placed upon it. After time,...

Blood levels of practolol after oral and parenteral administration were determined in normal subjects, the effects each dose on heart rate induced by strenuous exercise measured. Oral was rapidly absorbed produced peak blood 1 to 3 hours. Between 2 7 hours varied little more than twofold either within or between subjects. The half‐life 10 11 Practolol100 mg minimum produce near maximum blockade at hours; maintenance this effect for 24 reqUired 400 mg. Near as long a level 1.0 1.4 µg per...

Delivery of macromolecular drugs to airway cells after inhalation can be limited by rapid clearance, in vivo degradation, and poor intracellular targeting. Liposome carriers offer an effective method improving drug stability, but conventional liposomes have targeting capacity are cleared rapidly the lungs. Further modification is required improve liposome-cell interaction Therefore, we proposed conjugating three arginine-rich membrane translocating peptides, namely, HIV-TAT, Antennapedia,...

Summary β-Adrenoceptor density was measured in lymphocytes from neonates and normotensive hypertensive adults aged 18 to 85 years. Receptor did not differ young elderly people. In but people there a peak β-adrenoceptor middle life: otherwise, receptor densities were similar hypertensives. Neonates had lower lymphocyte than adults. Decreases β-adrenoceptor-mediated responses old age may be due alterations postreceptor events.

To investigate the possibility of altered digoxin receptor binding properties in neonates, we compared with erythrocytes from neonates and adults. Neonatal had two a half times as many sites adult erythrocytes. The neonatal "receptors" also dissociation constants for that were twice value. These findings suggest differences may explain clinical observation decreased sensitivity to infants. Clinical Pharmacology Therapeutics (1980) 28, 346–349; doi:10.1038/clpt.1980.172

This article describes the context and development of new Nurse Practitioner Standards for Practice in Australia, which went into effect January 2014. The researchers used a mixed-methods design to engage broad range stakeholders who brought both political practice knowledge standards. Methods included interviews, focus groups, surveys, work-based observation nurse practitioner practice. Stakeholders varied terms their need detail Nonetheless, they invariably agreed that standards should be...

Summary Platelet α 2 -and lymphocyte ß -adrenoceptor densities, plasma noradrenaline and serum Cortisol were measured before, during one week after a course of EEG-monitored electroconvulsive therapy, in nine depressed patients. A 50% fall Hamilton Depression Rating scores occurred fairly consistent total seizure time, regardless the amount ECT given. densities showed statistically significant three ECTs, but unchanged full independent clinical change. Lymphocyte unaltered. Plasma...

Displacement- and ionization-energy transfers to Si, SiO2, GaAs as functions of incident neutron energy were calculated using new cross section data fine group structure in the NJOY code system. Neutron spectra determinations for several reactor environments made activation sections a technique with SAND II code. Measurements carrier removal rates Si transistor gain degradation representative environments. Experimental results are compared damage ratios predicted displacement functions. For...