A5090796257- Retinal Development and Disorders
- Zebrafish Biomedical Research Applications
- Retinal Diseases and Treatments
- CRISPR and Genetic Engineering
Huazhong University of Science and Technology
2021-2022
Neural retina leucine zipper ( NRL ) is an essential gene for the fate determination and differentiation of precursor cells into rod photoreceptors in mammals. Mutations are associated with autosomal recessive enhanced S-cone syndrome dominant retinitis pigmentosa. However, exact role Nrl regulating development maintenance zebrafish Danio rerio ), a popular animal model used retinal degeneration regeneration studies, has not been fully determined. In this study, we generated nrl knockout via...
Abstract The neural retina leucine zipper ( NRL ) is an essential gene for the fate determination and differentiation of rod photoreceptors in mammals. Mutations have been associated with autosomal recessive enhanced S-cone syndrome dominant retinitis pigmentosa. However, exact role Nrl regulating development maintenance zebrafish, a popular animal model used retinal degeneration regeneration studies, has not fully determined. In this study, we generated nrl knockout zebrafish by CRISPR-Cas9...