A5080298948- Mosquito-borne diseases and control
- Fungal Infections and Studies
- SARS-CoV-2 detection and testing
- Biosensors and Analytical Detection
- Parasitic Infections and Diagnostics
- Plant Disease Resistance and Genetics
- Malaria Research and Control
- Antifungal resistance and susceptibility
- Phytoplasmas and Hemiptera pathogens
- Viral Infections and Vectors
- Nail Diseases and Treatments
- SARS-CoV-2 and COVID-19 Research
- Vector-Borne Animal Diseases
- Enterobacteriaceae and Cronobacter Research
- Trace Elements in Health
- Aquaculture disease management and microbiota
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- bioluminescence and chemiluminescence research
- Phytochemistry Medicinal Plant Applications
- Phytochemistry and Bioactivity Studies
- Microbial Natural Products and Biosynthesis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Toxoplasma gondii Research Studies
- Rabies epidemiology and control
Universidade Federal de Goiás
2017-2025
Universidade de Brasília
2016-2019
Inducing immunogenic cell death (ICD) during cancer therapy is a major challenge that might significantly improve patient survival. The purpose of this study was to develop theranostic nanocarrier, capable both conveying cytotoxic thermal dose when mediating photothermal (PTT) after its intravenous delivery, and consequently inducing ICD, improving nanocarrier consists red blood membranes (RBCm) embedding the near-infrared dye IR-780 (IR) camouflaging Mn-ferrite nanoparticles (RBCm-IR-Mn)....
Iron is an essential nutrient for all organisms. For pathogenic fungi, iron the success of infection. Thus, these organisms have developed high affinity uptake mechanisms to deal with metal deprivation imposed by host. Siderophore production one that fungal pathogens employ acquisition. Paracoccidioides spp. present orthologous genes encoding enzymes necessary biosynthesis hydroxamates, and plasma membrane proteins related transport molecules. All are induced in deprivation. In addition, it...
Arboviruses are a group of viruses transmitted to vertebrate hosts by certain blood-feeding arthropods. Among urban vectors arboviruses, mosquitoes the genus Aedes most common. However, other may be susceptible infection and involved in transmission, such as Mansonia spp. Therefore, this study aimed investigate whether humeralis can infected with Mayaro virus (MAYV).These insects were collected from 2018 2020 chicken coops rural communities Jaci Paraná Porto Velho, Rondônia, Brazil, while...
Aim: During infection development in the host, Paracoccidioides spp. faces deprivation of micronutrients, a mechanism called nutritional immunity. This condition induces remodeling proteins present different metabolic pathways. Therefore, we attempted to identify membrane and their regulation by zinc lutzii. Materials & methods: Membranes enriched fraction yeast cells P. lutzii were isolated, purified identified 2D LC–MS/MS detection database search. Results conclusion: Zinc suppressed...
Copper is an essential micronutrient for the performance of important biochemical processes such as respiration detoxification, and uptake metals like iron. Studies have shown that copper deprivation a strategy used by host against pathogenic fungi Cryptoccocus neoformans Candida albicans during growth development infections in lungs kidneys. Although there are some studies, little known about impact members Paracoccidioides genus. Therefore, using isobaric tag labeling (iTRAQ)-Based...
Zinc is one of the main micronutrients for all organisms. One defense mechanisms used by host includes sequestration metals in fungal metabolism, such as iron and zinc. There are several that maintain balance intracellular zinc supply. MicroRNAs effector molecules responses between pathogen host, favoring or preventing infection many microorganisms. Fungi Paracoccidioides genus thermodimorphic etiological agents paracoccidioidomycosis (PCM). In current pandemic scenario world mycosis studies...
Despite the advance of vaccination worldwide, epidemic waves caused by more transmissible and immune evasive genetic variants SARS-CoV-2 have sustained ongoing pandemic COVID-19. Monitoring such is expensive, as it usually relies on whole-genome sequencing methods. Therefore, necessary to develop alternatives that could help identify samples from specific variants. Reverse transcription loop-mediated isothermal amplification a method has been increasingly used for nucleic acid amplification,...
Eukaryotic cells have different mechanisms of post-transcriptional regulation. Among these mechanisms, microRNAs promote regulation targets by cleavage or degradation the mRNA. Fungi Paracoccidioides complex are etiological agents main systemic mycosis Latin America. These fungi present a plasticity to adapt and survive in conditions, presence microRNAs-like molecules could be part that provide such plasticity. MicroRNAs produced host influence progression this lungs besides regulating...
MicroRNAs are molecules involved in post-transcriptional gene regulation. In pathogenic fungi, microRNAs have been described at different morphological stages by regulating targets processes such as morphogenesis and energy production. Members of the Paracoccidioides complex main etiological agents a systemic mycosis Latin America. Fungi present wide range plasticity to colonize niches. response environmental changes these fungi undergo switch, remodel their cellular metabolism modulate...
Paracoccidioides spp. are thermally dimorphic fungi that cause paracoccidioidomycosis and can affect both immunocompetent immunocompromised individuals. The infection lead to moderate or severe illness death. undergo micronutrients deprivation within the host, including iron. To overcome such cellular stress, this genus of responds in multiple ways, as utilization hemoglobin. A glycosylphosphatidylinositol (GPI)-anchored fungal receptor, Rbt5, has primary role acquiring essential nutrient...
O atual surto de COVID-19 tornou-se uma séria ameaça à saúde das pessoas em todo o mundo. SARS-CoV-2 é facilmente transmitido através do contato com aerossóis, gotículas e fômites infectadas. No entanto, também foi detectado amostras fezes, sugerindo possível contaminação fecal oral. A epidemiologia baseada águas residuárias ferramenta monitoramento perfil microbiológico comunidade que pode contribuir para a identificação patógenos, auxiliando na tomada decisões, previamente aos surtos...
Mosquitos do gênero Mansonia spp. são abundantes em regiões que ocorreram modificações ecológicas promovidas pelo homem, como construções de usinas hidrelétricas, razão aumento macrófitas, indispensáveis na reprodução deste mosquito. Entretanto, não descritos vetores doenças, apesar algumas espécies serem relatadas naturalmente infectadas com alguns arbovírus Mayaro e Chikungunya, foram realizados estudos competência vetorial (Aitken, 1960; Diallo, 2012). O objetivo trabalho foi avaliar a...
Arboviral diseases are a group of infectious caused by viruses transmitted arthropods, mainly mosquitoes. These diseases, such as those the dengue (DENV), Zika (ZIKV), chikungunya (CHIKV), and yellow fever (YFV) viruses, have significant impact worldwide. In this context, entomological surveillance plays crucial role in control prevention arboviruses providing essential information on presence, distribution, activity vector Based surveillance, transovarian transmission provides regarding...