A5050297977- Trypanosoma species research and implications
- Antifungal resistance and susceptibility
- Cardiomyopathy and Myosin Studies
- Angiogenesis and VEGF in Cancer
- Carcinogens and Genotoxicity Assessment
- Metal complexes synthesis and properties
- Research on Leishmaniasis Studies
- Cardiovascular Disease and Adiposity
- HIV/AIDS oral health manifestations
- Nanoplatforms for cancer theranostics
- Chemotherapy-induced organ toxicity mitigation
- Fungal Infections and Studies
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- RNA and protein synthesis mechanisms
- Glycosylation and Glycoproteins Research
- Silymarin and Mushroom Poisoning
- Photoacoustic and Ultrasonic Imaging
- Pomegranate: compositions and health benefits
- Bioactive Compounds and Antitumor Agents
- Mycotoxins in Agriculture and Food
- Click Chemistry and Applications
- Galectins and Cancer Biology
- Mosquito-borne diseases and control
- Genomics, phytochemicals, and oxidative stress
Universidade Federal de Goiás
2016-2025
Universidade de Brasília
2005-2014
Resumo Objetivo: descrever os desafios da implantação do sistema de vigilância e prevenção chikungunya no Brasil. Métodos: estudo descritivo dos casos suspeitos doença notificados Sistema Informação Agravos Notificação (Sinan) entre 2014 2016. Resultados: período estudado, foram mais 100 mil prováveis país, com maior concentração nos estados Nordeste (83,3% 2015; 91,0% em 2016); o Sinan apresentou excelente oportunidade encerramento 2015 (85%) alta completitude das variáveis obrigatórias....
Inducing immunogenic cell death (ICD) during cancer therapy is a major challenge that might significantly improve patient survival. The purpose of this study was to develop theranostic nanocarrier, capable both conveying cytotoxic thermal dose when mediating photothermal (PTT) after its intravenous delivery, and consequently inducing ICD, improving nanocarrier consists red blood membranes (RBCm) embedding the near-infrared dye IR-780 (IR) camouflaging Mn-ferrite nanoparticles (RBCm-IR-Mn)....
Abstract Antimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make ruthenium(ii) complexes attractive the development of new chemotherapeutic agents cancer treatment. In this study, cytotoxic activities possible mechanism death induced by three ruthenium were evaluated, [Ru(MIm)(bipy)(dppf)]PF6 (1), [RuCl(Im)(bipy)(dppf)]PF6 (2) [Ru(tzdt)(bipy)(dppf)]PF6 (3). The results showed indexes triple-negative breast line (MDA-MB-231) with IC50 value index complex 1...
The administration of anti-trypanosome nitroderivatives curtails Trypanosoma cruzi infection in Chagas disease patients, but does not prevent destructive lesions the heart. This observation suggests that an effective treatment for requires understanding its pathogenesis.To understand origin clinical manifestations heart we used a chicken model system which can be initiated egg, parasite persistence is precluded. T. inoculation into air chamber embryonated eggs generated chicks retained only...
Delivery efficiencies of theranostic nanoparticles (NPs) based on passive tumor targeting strongly depend either their blood circulation time or appropriate modulations the microenvironment. Therefore, predicting NP delivery efficiency before and after a microenvironment modulation is highly desirable. Here, we present new erythrocyte membrane-camouflaged magnetofluorescent nanocarrier (MMFn) with long (92 h) high (10% ID for Ehrlich murine model). MMFns owe magnetic fluorescent properties...
Pedunculagin (PD), an ellagitannin found in different plant species, possesses several pharmaceutical properties, including antitumor, antioxidant, gastroprotective, hepatoprotective, and anti-inflammatory properties. However, the effects of PD alone on DNA remain to be determined. The aim this study was investigate potential cytotoxic, genotoxic, antigenotoxic activities isolated from Plinia cauliflora seeds using silico vitro assays. To elucidate biological PD, tools indicative...
IR-780 iodide is a fluorescent dye with optical properties in the near-infrared region that has applications tumor detection and photothermal/photodynamic therapy. This multifunctional effect led to development of theranostic nanoparticles both chemotherapeutic drugs such as docetaxel, doxorubicin, lonidamine. In this work, we developed two albumin-based containing dyes, one them possessing magnetic core. Molecular docking AutoDock Vina studies showed binds bovine serum albumin (BSA) greater...
Noninvasive thermometry during magnetic nanoparticle hyperthermia (MNH) remains a challenge. Our pilot study proposes methodology to determine the noninvasive intratumoral thermal dose MNH in subcutaneous tumor model.Two groups of Ehrlich bearing-mice with solid and carcinoma, control group (n = 6), treated 4) were investigated. Histopathology was used evaluate percentage non-viable lesions tumor. performed at 301 kHz 17.5 kA.m-1, using multifunctional nanocarrier. Surface temperature...
Silymarin (SM), a standardized extract derived from Silybum marianum (L.) Gaertn, is primarily composed of flavonolignans, with silibinin (SB) as its major active constituent. The present study aimed to evaluate the antigenotoxic activities SM and SB using alkaline comet assay in whole blood cells assess their effects on expression genes associated carcinogenesis chemopreventive processes. Different concentrations or (1.0, 2.5, 5.0, 7.5 mg/ml) were used combination DNA damage-inducing agent...
The aim of this article is to characterize the biological aspects oral strains C. albicans in children with Down's syndrome. These yeasts were analyzed as their macromorphological and enzymatic tested vitro susceptibility antifungal drugs using broth microdilution determine minimum inhibitory concentration (MIC). morphotyping revealed that all isolates from syndrome promoted formation fringes regardless size, while control group presented smaller fringes. All produced proteinase, but those...
Peritoneal carcinomatosis is considered as a potentially lethal clinical condition, and the therapeutic options are limited. The antitumor effectiveness of [Ru(l-Met)(bipy)(dppb)]PF6(1) [Ru(l-Trp)(bipy)(dppb)]PF6(2) complexes were evaluated in peritoneal model, Ehrlich ascites carcinoma–bearing Swiss mice. This first study that effect Ru(II)/amino acid for activity vivo. Complexes 1 2 (2 6 mg kg−1) showed tumor growth inhibition ranging from moderate to high. mean survival time animal groups...
Background Infection with the protozoan Trypanosoma cruzi manifests in mammals as Chagas heart disease. The treatment available for chagasic cardiomyopathy is unsatisfactory. Methods/Principal Findings To study disease pathology and its inhibition, we employed a syngeneic chicken model refractory to T. which chickens hatched from inoculated eggs retained parasite kDNA (1.4 kb) minicircles. Southern blotting EcoRI genomic DNA digests revealed main 18 20 kb bands by hybridization radiolabeled...