A5086718225- Phytochemistry Medicinal Plant Applications
- Iron Metabolism and Disorders
- Plant-Derived Bioactive Compounds
- Hemoglobinopathies and Related Disorders
- Metal complexes synthesis and properties
- Essential Oils and Antimicrobial Activity
- Carcinogens and Genotoxicity Assessment
- Biological Stains and Phytochemicals
- Phytochemical compounds biological activities
- Pomegranate: compositions and health benefits
- Intraperitoneal and Appendiceal Malignancies
- Edible Oils Quality and Analysis
- Advanced biosensing and bioanalysis techniques
- Intestinal and Peritoneal Adhesions
- Immune Response and Inflammation
- Fish biology, ecology, and behavior
- Vibrio bacteria research studies
- Biodiesel Production and Applications
- Click Chemistry and Applications
- Hemostasis and retained surgical items
- Sepsis Diagnosis and Treatment
- Phytochemistry and biological activity of medicinal plants
- Bioactive Natural Diterpenoids Research
- Mosquito-borne diseases and control
- Biomarkers in Disease Mechanisms
Pontifícia Universidade Católica de São Paulo
2015-2025
Pontifícia Universidade Católica de Goiás
2012-2022
Fundação de Apoio a Pesquisa do Estado de Goiás
2020
Universidade Federal de Goiás
2006
Punicalagin is the major ellagitannin constituent from leaves of Lafoensia pacari, a Brazilian medicinal plant widely used for treatment peptic ulcer and wound healing. Genotoxic, cytotoxic, antigenotoxic, anticytotoxic effects punicalagin were assessed using micronucleus (MN) test comet assay in mice. Due to extensive use L. pacari healing process, we also angiogenic activity chick chorioallantoic membrane (CAM) assay. The highest dose (50mg/kg) showed significant cytotoxic effect by MN...
O uso de plantas medicinais com propriedades terapêuticas é uma prática ancestral e continua a ser essencial na criação medicamentos tratamentos naturais. De acordo Organização Mundial da Saúde (OMS), grande parcela população países em desenvolvimento utiliza para cuidados básicos saúde. óleo lavanda (Lavandula angustifolia) possui diversas que o tornam amplamente utilizado produtos farmacêuticos aromaterapia. Estudos demonstram seus compostos, como α-pineno, terpin-4-ol linalol, possuem...
A utilização de plantas medicinais e das substâncias delas extraídas é tão antiga quanto a própria história do homem. evolução dos medicamentos se deu forma empírica, em processos descobertas por tentativas, erros acertos. Nesse sentido, o buriti (Mauritia flexuosa), uma palmeira da família Palmae, com distribuição ampla toda América tropical, incluindo as regiões Nordeste, Norte Centro-Oeste Brasil. Dessa forma, possui variedade aplicações uso popular todas suas partes (raízes, folhas,...
Abstract Antimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make ruthenium(ii) complexes attractive the development of new chemotherapeutic agents cancer treatment. In this study, cytotoxic activities possible mechanism death induced by three ruthenium were evaluated, [Ru(MIm)(bipy)(dppf)]PF6 (1), [RuCl(Im)(bipy)(dppf)]PF6 (2) [Ru(tzdt)(bipy)(dppf)]PF6 (3). The results showed indexes triple-negative breast line (MDA-MB-231) with IC50 value index complex 1...
Abstract The Brazilian Cerrado biome consists of a great variety endemic species with several bioactive compounds, and Anadenanthera peregrina (L.) Speg is promising species. In this study, we aimed to perform phytochemical characterization evaluate the antioxidant antibacterial activities against Staphylococcus aureus Escherichia coli hydroethanolic extract A. stem bark. barks were collected in Botanical Garden Goiânia, Brazil. was obtained by percolation subjected physicochemical...
The Hancornia speciosa latex reveals angiogenic, osteogenic, and anti-inflammatory properties, which present its potential for developing of wound healing drugs; however, the compounds responsible angiogenesis remain unknown. One strategy to screen these active is evaluation fractions. This study aimed obtain different fractions evaluate angiogenic activity separately using chick chorioallantoic membrane (CAM) assay. serum (SE) fraction was angiogenesis, subject biochemical characterization...
This study analyzed the physicochemical and photophysical properties of essential oil Curcuma longa its angiogenic potential. The results showed that curcumin is main fluorescent component present in oil, although amount relatively small. experimental chorioallantoic membrane model was used to evaluate activity, showing a significant increase vascular network positive control groups when compared neutral inhibitor controls (P <0.05), but no difference found between >0.05). Histological...
RESUMO O Barbatimão (Stryphnodendron adstringens) planta medicinal encontrada no bioma Cerrado apresenta propriedades físico-químicas que lhe garante importantes atividades farmacológicas tais como: anti-inflamatória, analgésica e uma atividade protetora da mucosa gástrica. A casca do tronco é a principal matéria-prima usada para o desenvolvimento de produtos medicinais. Neste estudo, objetivo foi investigar influência solução aquosa barbatimão processo formação vasos sanguíneos na membrana...
Peritoneal carcinomatosis is considered as a potentially lethal clinical condition, and the therapeutic options are limited. The antitumor effectiveness of [Ru(l-Met)(bipy)(dppb)]PF6(1) [Ru(l-Trp)(bipy)(dppb)]PF6(2) complexes were evaluated in peritoneal model, Ehrlich ascites carcinoma–bearing Swiss mice. This first study that effect Ru(II)/amino acid for activity vivo. Complexes 1 2 (2 6 mg kg−1) showed tumor growth inhibition ranging from moderate to high. mean survival time animal groups...
The aim of this study was to evaluate the possible protective C. guianensis oil against MMC and CP, which are direct- indirect-acting chemical mutagens, using micronucleus test. Three experiments were performed. First co-administered mice at doses 250, 500 1000 mg/kg bw with 4 or 50 CP. Second, mutagenic drug (CP) administered ip after 6 12 hours 250 administered. In last, administrated (250 bw) during five days it results obtained showed that is not cytotoxic neither genotoxic mouse bone...
As anemias hereditárias, que englobam as hemoglobinopatias e talassemias são doenças determinadas geneticamente. Na maioria dos casos os heterozigotos assintomáticos desconhecem o defeito genético do qual portadores. De uma forma geral existe deficiência no diagnóstico clínico laboratorial para a investigação destas acometem parcela significativa da população brasileira. A comunicação deste caso à comunidade científica tem como objetivo destacar importância de um clínico-laboratorial...
Background: The use of plants the family Euphorbiaceae, particularly Euphorbia tirucalli (avelós) has been popularly widespread for treating a variety diseases infectious, tumoral, and inflammatory. Aim: To demonstrated antimicrobial immunomodulatory effects these extracts, evaluating effect topical treatment with an aqueous solution avelós latex on survival intestinal adhesions in rats experimental peritonitis. Methods: Peritonitis was induced 24 Wistar rats, that were randomized into four...
Background: The development of drugs capable enhance or inhibit the cell proliferation is an area in expansion at modern biomedical sciences. Recent researches have shown that latex has strong angiogenic potential. Methods: We performed a bibliometric analysis on global literature trying to identify: main scientometrics data, botanical families and species, antiangiogenic properties also discussed results obtained this topic up now. Results: different approaches, showed continuous increase...
Sepsis induces a severe systemic inflammatory response that may result in multiple organ dysfunction and death. Studies using protein derived from natural Hevea brasiliensis (rubber tree) latex, denominated Hev b 13, have demonstrated important anti-inflammatory effects, but no data been published regarding its effects on sepsis. The aim of this study was to investigate the 13 lung lesions septal rats. Male Wistar rats were submitted cecal ligation puncture (CLP), randomized into groups...
Chalcones are chemically defined as α,β–unsaturated ketones with a 1,3-diphenyl-2-propen-1-one nucleus. These compounds occur naturally in plants and considered precursors of flavonoids. Given that evaluating genetic toxicology tests is essential investigating the safe use chemopreventive potential different natural synthetic compounds, this study aimed to assess genotoxic, cytotoxic, antigenotoxic, anticytotoxic activity chalcone...
Aims: To assess the angiogenic activity of sucupira (Pterodon emarginatus) oil, popularly used as an antirheumatic, analgesic, antimicrobial, and anti-inflammatory agent.Methods: The chick (Gallus domesticus) embryo chorioallantoic membrane (CAM) assay was experimental model, incubated in a temperature- humidity- controlled automatic incubator during first five days. A circular hole made at wider base eggshell on fifth day. After 13 days incubation, filter paper discs containing oil control...
A Aloe vera, popularmente conhecida como babosa, é uma das plantas mais utilizadas no tratamento de feridas, visto que inúmeras pesquisas relatam suas propriedades cicatrizantes e anti-inflamatórias. O objetivo do estudo foi avaliar a influência da vera na atividade cicatricial feridas induzidas em dorso ratos. Foram utilizados 15 ratos saudáveis espécie Rattus norvegicus albinus. Por intermédio criação lesão cada rato utilizando um molde tamanho retangular 2,0 x 3,0 cm, aplicado o gel...
As anemias hereditárias, em especial as talassemias e hemoglobinas (Hb) variantes, são mais comuns das alterações genéticas humanas; sua freqüência na população brasileira é muito variável, dependendo dos grupos raciais formadores de cada região. O povoamento Goiás, que teve início logo após o seu descobrimento, 1726, motivado pela procura ouro, foi composto principalmente por portugueses escravos africanos, contexto favoreceu a mestiçagem entre eles. Considerando esses povos apresentam...
The present study aimed to assess the cytotoxic, genotoxic, and antigenotoxic activities of sucupira oil (Pterodon emarginatus), which is commonly used as an anti-rheumatic, analgesic, antimicrobial, anticercariae, anti-inflammatory. We mouse bone marrow micronucleus test experimental model. groups, consisted 5 animals, was administered (100 mg/kg body weight) intraperitoneally evaluated 24 h after treatment. negative control group treated with sterile distilled water, positive received...