Yeast recycling, which is a common practice in sugarcane ethanol plants, could be expanded if it successfully implemented corn-based production. However, the process of recycling yeast remaining after fermentation hampered by contaminating microorganisms that reduce efficiency and compete with for fermentable sugars. Currently, antibiotics are used to control microbial contamination. This study proposes chlorine dioxide electron beam irradiation as alternative methods completely inactivating...

INTRODUÇÃO: A hemorragia digestiva alta (HDA) é definida pelo sangramento do trato digestivo alto, uma das emergências gastroenterológicas mais comuns, com mortalidade de cerca 10% em 30 dias, especialmente idosos. OBJETIVOS: Comparar os desfechos (óbito, e ressangramento) pacientes admitidos HDA aos fatores preditores clínicos identificados na admissão. METODOLOGIA: Estudo longitudinal, retrospectivo analítico realizado no Hospital Cirurgia. Foram incluídos maiores 18 anos por excluídos...

Abstract The Brazilian Cerrado biome consists of a great variety endemic species with several bioactive compounds, and Anadenanthera peregrina (L.) Speg is promising species. In this study, we aimed to perform phytochemical characterization evaluate the antioxidant antibacterial activities against Staphylococcus aureus Escherichia coli hydroethanolic extract A. stem bark. barks were collected in Botanical Garden Goiânia, Brazil. was obtained by percolation subjected physicochemical...

High-gravity fermentation, used for ethanol production from sugarcane, corn, and mixed substrates, offers several benefits. Yeast, a rapidly multiplying unicellular microorganism, can be adapted high sugar tolerance on lab scale. However, different substrates enhance fermentation efficiency. Our study consisted of two experiments. In the first, we compared simple batch feeding with fed-batch system yeast selection in high-gravity fermentation. We ran eight cycles increasing initial contents...

The Hancornia speciosa latex reveals angiogenic, osteogenic, and anti-inflammatory properties, which present its potential for developing of wound healing drugs; however, the compounds responsible angiogenesis remain unknown. One strategy to screen these active is evaluation fractions. This study aimed obtain different fractions evaluate angiogenic activity separately using chick chorioallantoic membrane (CAM) assay. serum (SE) fraction was angiogenesis, subject biochemical characterization...

Pedunculagin (PD), an ellagitannin found in different plant species, possesses several pharmaceutical properties, including antitumor, antioxidant, gastroprotective, hepatoprotective, and anti-inflammatory properties. However, the effects of PD alone on DNA remain to be determined. The aim this study was investigate potential cytotoxic, genotoxic, antigenotoxic activities isolated from Plinia cauliflora seeds using silico vitro assays. To elucidate biological PD, tools indicative...

This paper presents an approach for assisting low-literacy readers in accessing Web online information. The “Educational FACILITA” tool is a content adaptation that provides innovative features and follows more intuitive interaction models regarding accessibility concerns. Especially, we propose model application explore the natural language processing tasks of lexical elaboration named entity labeling improving accessibility. We report on results obtained from pilot study usability analysis...

In this paper we describe a web content adaptation tool for assisting low-literacy readers to access online information. The "Educational FACILITA" provides innovative features and the design of more intuitive interaction models. Especially, propose an model application that explore Natural Language Processing tasks lexical elaboration named entity labeling improving accessibility.

This work showcased the first physicochemical investigation of psoralen (PSO) binding to double stranded DNA (dsDNA) through electroanalytical methods. Results evidenced that PSO presents one non-reversible anodic peak at electric potential (Epa) ≈ 1.42 V, which is associated with its oxidation and formation an epoxide derivative. Moreover, analytical signal (i.e., faradaic current) decreases linearly addition dsDNA, while shifts towards more positive values, indicating thence dsDNA hinders...

In this work, we developed and validated a HPLC-PDA method for the quantification of hibalactone in Hydrocotyle umbellata L., Araliaceae, subterraneous parts extracts optimized its ultrasound-assisted extraction. Chromatographic separations were carried out with an isocratic mobile phase acetonitrile/methanol/water (10:65:25), flow 0.8 ml min−1, detection at 290 nm C18 column (250 × 4.6 mm, 5 μm). The validation parameters determined according to Brazilian legislation. optimization...

Hibalactone (HB) is a lignan related to the anxiolytic-like effects of Hydrocotyle umbellata L. However, there need understand better mechanism action this support ethnopharmacological uses species. This work aimed evaluate by in vivo and silico analysis HB involved its effects.The mice were evaluated on light-dark box (LDB) elevated plus maze (EPM) tests. The participation 5-HT1A receptor benzodiazepine site GABAA was investigate possible action. In tools used elucidate HB.Oral treatment...

Coumarins and chalcones are compounds widely found in plants or obtained by synthetic methods which possess several biological properties including antioxidant, anti-inflammatory, antitumor effects. A series of coumarin-chalcone hybrids were synthesized to improve their actions reduce potential adverse Considering the applications these molecules, a hybrid [7-methoxy-3-(E)-3-(3,4,5-trimethoxyphenyl) acryloyl-2 H-chromen-2-one] (4-MET) was genotoxic, cytotoxic, protective effects assessed...

Oenothein B (OeB) is a dimeric ellagitannin with potent antioxidative, antitumor, immunomodulatory, and anti-inflammatory properties. Despite the promising activities of OeB, studies examining genotoxic or protective effects this on DNA are scarce. Therefore, to further comprehensively elucidate chemopreventive profile aim study was evaluate mutagenic antimutagenic actions OeB using Salmonella typhimurium strains Ames test. The micronucleus (MN) test comet assay were used assess...

To propose a plausible binding mode between piperine and derivatives inside acetylcholinesterase (AChE) by molecular docking simulations, which might explain the observed experimental inhibitory activity of enzyme, anticholinesterase compounds was tested using microplate- reader assay based on Ellman method modified Rhee. Docking simulations were performed with GOLD 4.1 program AChE donepezil due to structural similarity this drug piperine. Piperine, piperic acid, ester exhibit in vitro...

Eugenia punicifolia (Kunth) DC, known as “pedra ume-caá” or “pitanguinha do cerrado”, is popularly used to treat infectious diseases like inflammation, and diabetes. Therefore, this study aimed develop validate an analytical method by high-performance liquid chromatography with diode array detector (HPLC-DAD) for the seasonal quantification of gallic acid (GA) ellagic (EA), co-validate from ethanol extract fractions E. leaves. Chromatographic separations were performed a mobile phase...

Hydrocotyle umbellata L., Araliaceae, is a species that recommended in Ayurvedic medicine for its effects on the central nervous system, such as anxiolytic and memory-stimulant effects. Despite medicinal potential of this species, phytopharmaceutical technological to produce standardized extracts has not been investigated. This study analyzes influence spray drying parameters contents chemical markers (total phenolic, total flavonoid, hibalactone) functional properties H. extract. The...

Cancer disease is characterized by genomic abnormalities and gene expression aberrations that leads to misregulated activity of apoptosis, angiogenesis cell proliferation. Heterogeneous ribonucleoprotein K (hnRNP K) a constitutive protein found in nucleus, cytoplasm mitochondria cells interacts with molecules involved signal transduction pathways. It believed the over hnRNP prostate, breast colorectal cancer types. The binding nucleotides main interaction triggers biological mediated its...

Background: Capsaicinoids content of peppers is one the major parameters that determine its commercial and nutritional values. Despite their properties application in food industry, capsaicinoid compounds have been widely studied pharmaceutical area due to therapeutic activities such as antioxidant, antimicrobial, antitumor, antiobesity, anti-inflammatory analgesic effects. Keywords: Pepper, capsaicin, bioactivity prediction, acetylcholinesterase.

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A cárie dentária é uma das doenças crônicas mais prevalentes em todo o mundo, especialmente entre crianças, sendo amplamente reconhecida como um desafio de saúde pública. Apesar dos avanços na odontologia preventiva e promoção bucal, a continua afetando parcela significativa da população infantil, principalmente contextos socioeconômicos vulneráveis. Assim, este estudo teve objetivo analisar as principais estratégias prevenção destacando intervenções eficazes suas aplicações práticas no...