A5014288455- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Porphyrin and Phthalocyanine Chemistry
- Protein Interaction Studies and Fluorescence Analysis
- Synthesis of Tetrazole Derivatives
- Synthesis and Biological Evaluation
- Lanthanide and Transition Metal Complexes
- Synthesis and Characterization of Heterocyclic Compounds
- DNA and Nucleic Acid Chemistry
Universidade Federal de Goiás
2019-2021
Institut des Sciences Biologiques
2019
Ru(<sc>ii</sc>)/2-mercaptopyrimidine complexes active against cancer cells did not present toxic effects during embryonic and larval development of zebrafish.
This study reports the synthesis, structural characterization and cytotoxic activity of four new palladium/pyridylporphyrin complexes, with general formula {TPyP[PdCl(P-P)]4}(PF6)4, where P-P is 1,2-bis(diphenylphosphino)ethane (dppe), 1,3-bis(diphenylphosphino)propane (dppp), 1,2-bis(diphenylphosphino)butane (dppb) or 1,1'-bis(diphenylphosphino)ferrocene (dppf). The complexes were characterized by elemental analysis, FT-IR, UV/Vis, 1H 31P{1H} NMR (1D/2D) spectroscopy. slow evaporation a...
There is a concern about stablishing the clinical risk of drugs used for cancer treatment. In this study, cytotoxic, clastogenic and genotoxic properties cis-tetraammine(oxalato)ruthenium(III) dithionite - cis-[Ru(C2O4)(NH3)4]2(S2O6), were evaluated in vitro human lymphocytes. The mitotic index (MI), chromosomal aberrations (CA) DNA damage by comet assay also analyzed. MTT test revealed that ruthenium compound showed slight cytotoxic effect at highest concentration tested. IC50 value after...