A5000513798- Glycosylation and Glycoproteins Research
- Peripheral Neuropathies and Disorders
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Toxin Mechanisms and Immunotoxins
- Hereditary Neurological Disorders
- Innovations in Medical Education
- Cell Adhesion Molecules Research
- Autoimmune Neurological Disorders and Treatments
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Clinical practice guidelines implementation
- Complement system in diseases
- Proteoglycans and glycosaminoglycans research
- Child Nutrition and Feeding Issues
- Erythrocyte Function and Pathophysiology
- Resilience and Mental Health
- Phonetics and Phonology Research
- Grit, Self-Efficacy, and Motivation
- Congenital Heart Disease Studies
- Trace Elements in Health
- Vestibular and auditory disorders
- Ion Transport and Channel Regulation
- Clinical Reasoning and Diagnostic Skills
- Respiratory viral infections research
Tokyo Medical and Dental University
1998-2024
Iwata City Hospital
2024
Kyoto Prefectural University of Medicine
2012-2020
Tokyo Medical and Dental University Hospital
2010
Williams & Associates
2000
Tokyo Metropolitan Institute of Medical Science
2000
Tokyo Metropolitan Neurological Hospital
1999
Virginia Commonwealth University Medical Center
1993-1998
Virginia Commonwealth University
1995-1997
Inserm
1996
This report was written by the Japanese Society of Dysphagia Rehabilitation, Association Rehabilitation Nutrition, on Sarcopenia and Frailty, Swallowing Japan to consolidate currently available evidence topics sarcopenia dysphagia. Histologically, swallowing muscles are different embryological origin from somatic muscles, receive constant input stimulation respiratory center. Although striated, their characteristics those skeletal muscles. The inevitably affected malnutrition disuse;...
Objectives As more emphasis is placed on the acquisition of competencies in medical education, portfolios are increasingly being used for evaluation. EPOC2 (E-POrtfolio Clinical training) an e-portfolio system developed Japan and by about 800 clinical training hospitals. The study objective to identify learning trajectory junior residents provide insights into provision better postgraduate undergraduate education Japan. Design Longitudinal cohort study. Setting Hospitals nationwide adopting...
Using an in vitro blood-nerve barrier (BNB) model, the authors tested effect of various monoclonal antiganglioside antibodies on BNB function. Only anti-GM1 antibody significantly facilitated leakage a concentration-dependent, complement-independent manner. This study provided evidence that antibody, frequently detected sera from patients with inflammatory neuropathies, may participate dysfunction and contribute to development neuropathy.
Treatment of cultured bovine brain microvascular endothelial cells (BMECs) with interleukin 1 beta (IL-1 beta), an inflammatory cytokine, was shown to induce the accumulation sulfoglucuronosyl paragloboside (SGPG), a glycolipid bearing HNK-1 epitope. This resulted in attachment greater number human lymphocytes treated than untreated BMEC monolayers. Attachment IL-1 beta-activated could be blocked either by incubation anti-L-selectin antibody or application anti-SGPG BMECs. These results...
Depression amongst medical students is a crucial matter. Grit, which potentially modifiable psychological factor, has been inversely linked to depressive symptoms. However, it remains unclear how grit associated with depression. This study aims examine the relationship between and symptoms further investigate potential effect modification by academic performance on association depression among students. We focus total score its subscales, namely perseverance of effort consistency interest. A...
To evaluate morphologic changes in small endoneurial vessels patients with autoimmune demyelinative neuropathy and antiglycosphyngolipid antibodies.Although a humoral immune cause has been postulated for various demyelinating neuropathies, the mechanism by which large molecules like immunoglobulins can traverse blood-nerve barrier (BNB) to enter endoneurium is not understood.We examined histologic ultrastructural sural nerve biopsy specimens from patients, or without anti-glycosphingolipid...
In Guillain-Barré syndrome (GBS), the destruction or malfunction of blood-nerve barrier (BNB) has been considered to be beginning disease process. It is unclear whether sera from patients with GBS can open BNB, and which component patient most important in dysregulation BNB.The authors evaluated effect on permeability an vitro BNB model using bovine endoneurial microvascular endothelial cells (PnMEC) cultured luminal side a collagen-coated culture insert (pore size: 0.4 micro m).PnMEC...
Penetration of immunoglobulins and/or migration activated lymphocytes into peripheral nervous system (PNS) parenchyma are the initial key steps to develop immunological disorders PNS including Guillain-Barré syndrome, IgM neuropathy and chronic inflammatory demyelinating polyradiculoneuropathy. Hence, it is important know cellular property endothelial cells endoneurial tissue origin (PnMEC) because these constitute bulk blood-nerve barrier (BNB). For this purpose, we developed a method...
We have studied the glycolipid composition of human cataractous lenses. Neutral and acidic lipid fractions were isolated by column chromatographies on DEAE-Sephadex Iatrobeads. The neutral fraction contained 0.6-0.9 micrograms lipid-bound glucose (Glc) per mg protein 0.8-1.3 sialic acid (NeuAc) protein, respectively. was found to contain LacCer (39.0% total glycolipids), Gb3 (16.2%), Gb4 (1.1%), nLc4 (5.0%), X (29.0%), Y (9.2%). mainly GM3 (33.1% ganglioside fraction), GM1 (8.3%), LM1...
Abstract Glycosphingolipid (GSL) antigens have been considered to be involved in the pathogenesis of autoimmune neurologic disorders including multiple sclerosis. To establish GSL pattern specific for endothelial cells forming blood–brain barrier (BBB), we established a method yield sufficient quantities highly purified human brain microvascular (HBMECs) and compared their composition that umbilical cord vein (HUVECs), as representative not BBB. The major gangliosides were GM3 sialyl...
Cryptococcus neoformans (C. neoformans) var. gattii infection usually occurs in tropical and subtropical areas, rarely the northern hemisphere. We report first Japanese with cryptococcal meningoencephalitis caused by C. that occurred during a trip to Australia. This agent was identified cerebellar biopsy specimen immunohistochemical technique serotype-specific anti-sera. Because meningitis it did not respond well conventional therapy, we used an aggressive therapeutic regimen successfully...
The COVID-19 pandemic had an additional negative impact on the mental health of healthcare workers, including residents. Previous studies revealed that grit, which is individual trait to achieve long-term goals unrelated intelligence quotient, not only positively associated with academic achievement and career success but also negatively correlated depression. This study aimed examine association between grit depressive symptoms among residents at time job start during coronavirus disease...
Abstract Background Most Japanese medical schools likely continue to rely on peer physical examination (PPE) as a tool for teaching skills students. However, the attitudes of students in Japan toward PPEs have not be identified. Therefore, we evaluated students’ PPE school preparation developing policy tailored context culture. Methods We conducted mixed-methods study with an explanatory sequential approach, which qualitative data were used interpret quantitative findings. Surveys and...
This study examines the impact of 2010 and 2016 Model Core Curriculum (MCC) revisions on medical education across all 82 schools in Japan.
Antibodies against sulfoglucuronosyl glycosphingolipids (SGGLs) are known to be present in sera of patients with chronic polyneuropathy associated IgM paraproteinemia. We recently studied rats sensitized paragloboside (SGPG), a major SGGL species, emulsified keyhold limpet hemocyanin and Freund's adjuvant. The titer the class antibodies SGPG increased up 1:1,600, while that IgG 1:800 2 weeks after sensitization. showed high degree antigenic specificity; no cross-reactivity other brain...
Female sexual behavior is controlled by central estrogenic action in the ventromedial nucleus of hypothalamus (VMN). This region plays a pivotal role facilitating sex-related response to estrogen stimulation via neural activation several neurotransmitters, including histamine, which participates this mechanism through its strong potentiating action. However, signaling linked histamine system VMN unclear. study was undertaken investigate relationship between and receptor subtype H1 (H1R),...
The commonly used procedures for in situ hybridization require treatment of the tissue with non-ionic detergents and proteolytic enzymes, resulting considerable loss morphological detail. In this study proteinase pre-treatment was replaced by saponin, a highly surface-active plant glycoside. This saponin allowed good preservation morphology, as determined differential interference contrast enhanced video microscopy. Saponin resulted an equal or even better sensitivity probes recognizing...
Sulfoglucuronosyl paragloboside (SGPG) is a member of the sulfated glucuronic acid-containing glycolipid (SGGL) family found primarily in peripheral nerves. These glycolipids contain HNK-1 carbohydrate epitope and are recognized by monoclonal IgM from patients with chronic demyelinating neuropathy paraproteinemia. Recent studies indicate that SGGLs may serve as ligands for selectins, amphoterin, laminin, suggesting these play an important role cellular adhesion. To elucidate biological...