A5021621511- Arsenic contamination and mitigation
- Heavy Metal Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Drug Transport and Resistance Mechanisms
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- RNA Research and Splicing
- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Trace Elements in Health
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neuropharmacology Research
- Data Mining Algorithms and Applications
- Advanced Image and Video Retrieval Techniques
- Heavy metals in environment
- RNA modifications and cancer
- Pomegranate: compositions and health benefits
- RNA regulation and disease
- Geophysical and Geoelectrical Methods
- Lipid Membrane Structure and Behavior
- Pregnancy and Medication Impact
- Fish Biology and Ecology Studies
- Molecular Biology Techniques and Applications
- Image Retrieval and Classification Techniques
- Rough Sets and Fuzzy Logic
Indian Institute of Technology Jodhpur
2025
University of Louisville
2020-2024
University of Alberta
2014-2024
University of Louisville Hospital
2023
Center for Environmental Health
2023
University of Burdwan
2018
Indian Institute of Chemical Biology
1995-2014
University of Manchester
2010-2014
Zhejiang University
2014
Council of Scientific and Industrial Research
2008-2011
Abstract Arsenic in drinking water may cause major deleterious health impacts including death. Although arsenic rice has recently been demonstrated to be a potential exposure route for humans, there date no direct evidence the impact of such on human health. Here we show first time, through cohort study West Bengal, India, involving over 400 subjects not otherwise significantly exposed water, elevated genotoxic effects, as measured by micronuclei (MN) urothelial cells, associated with staple...
Microplastics (MP) derived from the weathering of polymers, or synthesized in this size range, have become widespread environmental contaminants and found their way into water supplies food chain. Despite awareness, little is known about health consequences MP ingestion. We previously shown that consumption polystyrene (PS) beads was associated with intestinal dysbiosis diabetes obesity mice. To further evaluate systemic metabolic effects PS on gut-liver-adipose tissue axis, we supplied...
The gene for glutathione-S-transferase (GST) M1 (GSTM1), a member of the GST-superfamily, is widely studied in cancer risk with regard to homozygous deletion (GSTM1 null), leading lack corresponding enzymatic activity. Many these studies have reported inconsistent findings regarding its association risk. Therefore, we employed silico, vitro and vivo approaches investigate whether absence functional GSTM1 enzyme null variant can be compensated by other family members. Through silico approach,...
In West Bengal, India more than 6 million people are exposed to high levels of arsenic through drinking water. Since, only 15–20% the individuals show arsenic-induced skin lesions, it is assumed that genetic variation might play an important role in toxicity and carcinogenicity. Arsenic exposure often leads development hyperkeratosis, precursor cancer. ERCC2 (excision repair cross-complementing rodent deficiency, complementation group 2) a nucleotide excision pathway gene, its SNPs have been...
Abstract In West Bengal, India, although more than 6 million people are exposed to arsenic through drinking water, only 15–20% showed arsenic‐induced skin lesions, including premalignant hyperkeratosis. This indicates toward some factors that confer susceptibility carcinogenicity. this work, we wanted explore whether differences in DNA repair capacity could impart carcinogenicity, Comet assay, chromosomal aberration (CA) assay and challenge assay. Sixty (30 individuals with hyperkeratosis 30...
Hundreds of millions people worldwide are exposed to unacceptable levels arsenic in drinking water. This is a public health crisis because Group I (proven) human carcinogen. Human cells methylate monomethylarsonous acid (MMA<sup>III</sup>), monomethylarsonic (MMA<sup>V</sup>), dimethylarsinous (DMA<sup>III</sup>), and dimethylarsinic (DMA<sup>V</sup>). Although the liver predominant site for methylation, elimination occurs mostly urine. The protein(s) responsible transport from (into blood),...
Abstract Chronic arsenic exposure causes skin cancer, although the underlying molecular mechanisms are not well defined. Altered microRNA and mRNA expression likely play a pivotal role in carcinogenesis. Changes genome-wide differential of miRNA at 3 strategic time points upon chronic sodium arsenite (As 3+ ) were investigated well-validated HaCaT cell line model arsenic-induced cutaneous squamous carcinoma (cSCC). Quadruplicate independent cultures exposed to 0 or 100 nM As for up 28-weeks...
Background: Chronic arsenic exposure via drinking water is associated with an increased risk of developing cancer and noncancer chronic diseases. Pre-mRNAs are often subject to alternative splicing, generating mRNA isoforms encoding functionally distinct protein isoforms. The resulting imbalance in isoform species can result pathogenic changes critical signaling pathways. Alternative splicing as a mechanism arsenic-induced toxicity carcinogenicity understudied. Objective: This study aimed...
Exposure to arsenic, a class I carcinogen, affects 200 million people globally. Skin is the major target organ, but molecular etiology of arsenic-induced skin carcinogenesis remains unclear. Arsenite (As3+)-induced disruption alternative splicing could be involved, mechanism unknown. Zinc finger proteins play key roles in splicing. As3+ can displace zinc (Zn2+) from C3H1 and C4 motifs (zfm's), affecting protein function. ZRANB2, an regulator with two zfm's integral its structure function,...