Tharanga Samarakoon

ORCID: 0000-0003-3038-6170
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About
Contact & Profiles
Research Areas
  • Essential Oils and Antimicrobial Activity
  • Phytochemistry and Biological Activities
  • Natural product bioactivities and synthesis
  • Psidium guajava Extracts and Applications
  • Ethnobotanical and Medicinal Plants Studies
  • Plant and animal studies
  • Genetic diversity and population structure
  • Botany, Ecology, and Taxonomy Studies
  • Phytochemical compounds biological activities
  • Pharmacological Effects of Natural Compounds

Emory University
2020-2023

The rise of antibiotic resistance presents a significant healthcare challenge and precludes the use many otherwise valuable antibiotics. One potential solution to this problem is antibiotics in combination with resistance-modifying agents, compounds that act synergistically existing resensitize previously resistant bacteria. In study, 12(S),16ξ-dihydroxycleroda-3,13-dien-15,16-olide, clerodane diterpene isolated from medicinal plant Callicarpa americana, was found synergize oxacillin against...

10.1021/acsinfecdis.0c00307 article EN ACS Infectious Diseases 2020-06-24

Abstract Throughout the SARS-CoV-2 pandemic, use of botanical dietary supplements in United States has increased, yet their safety and efficacy against COVID-19 remains underexplored. The Quave Natural Product Library is a phylogenetically diverse collection fungal natural product extracts including popular supplement ingredients. Evaluation 1867 18 compounds for virus spike protein binding to host cell ACE2 receptors pseudotyped system identified 310 derived from 188 species across 76...

10.1038/s41598-023-28303-x article EN cc-by Scientific Reports 2023-01-23

Abstract Premise Glacial/interglacial cycles and topographic complexity are both considered to have shaped today's diverse phylogeographic patterns of taxa from unglaciated eastern North America (ENA). However, few studies focused on the phylogeography population dynamics wide‐ranging ENA herbaceous species occurring in forest understory habitat. We examined pattern evolutionary history Podophyllum peltatum L., a widely distributed herb inhabiting deciduous forests ENA. Methods Using...

10.1002/ajb2.16254 article EN American Journal of Botany 2023-11-01
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