A5022879656- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Genomics and Phylogenetic Studies
- Microbial Natural Products and Biosynthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Metabolomics and Mass Spectrometry Studies
- Hops Chemistry and Applications
- Plant and Fungal Species Descriptions
- Traditional and Medicinal Uses of Annonaceae
- Phytochemistry and Biological Activities
- Plant Gene Expression Analysis
- Sesquiterpenes and Asteraceae Studies
- Fungal Plant Pathogen Control
- Piperaceae Chemical and Biological Studies
- Enzyme Structure and Function
- Herbal Medicine Research Studies
- Phytochemistry and Bioactivity Studies
- Synthesis and Biological Evaluation
- Mycorrhizal Fungi and Plant Interactions
- Plant Molecular Biology Research
- Plant chemical constituents analysis
- Cancer therapeutics and mechanisms
- DNA and Nucleic Acid Chemistry
- Plant Toxicity and Pharmacological Properties
Emory University
2022-2024
Seoul National University
2016-2023
Sookmyung Women's University
2021
The depside and depsidone series compounds of polyketide origin accumulate in the cortical or medullary layers lichen thalli. Despite taxonomic ecological significance chemistry its pharmaceutical potentials, there has been no single piece genetic evidence linking biosynthetic genes to substances. Thus, we systematically analyzed synthases (PKSs) for categorization identification gene cluster (BGC) involved depside/depsidone production. Our in-depth analysis interspecies PKS diversity genus
Selaginellins are unique pigments found in the genus Selaginella, largest of Lycopodiophyta. Recent studies reported that some selaginellin analogues have potent phosphodiesterase-4 (PDE4) inhibitory activity. In this study, chemical diversity natural derivatives was revealed by an MS/MS molecular networking-based dereplication Selaginella tamariscina extract. It led to prioritization chromatographic peaks predicted as previously unknown derivatives. Targeted isolation these compounds...
Abstract Throughout the SARS-CoV-2 pandemic, use of botanical dietary supplements in United States has increased, yet their safety and efficacy against COVID-19 remains underexplored. The Quave Natural Product Library is a phylogenetically diverse collection fungal natural product extracts including popular supplement ingredients. Evaluation 1867 18 compounds for virus spike protein binding to host cell ACE2 receptors pseudotyped system identified 310 derived from 188 species across 76...
The structural determination of natural products (NPs) can be arduous because sample heterogeneity. This often demands iterative purification processes and characterization complex molecules that may available only in miniscule quantities. Microcrystal electron diffraction (microED) has recently shown promise as a method to solve crystal structures NPs from nanogram quantities analyte. However, its implementation NP discovery remains hampered by throughput purity requirements, akin...
Novel mutations of OsCOP1 were identified to be responsible for yellowish pericarp and embryo lethal phenotype, which revealed that plays a crucial role in flavonoid biosynthesis embryogenesis rice seed. Successful production viable seeds is major component plant life cycles, seed development complex, highly regulated process affects characteristics such as viability color. In this study, three yellowish-pericarp (yel) mutants, yel-hc, yel-sk, yel-cc, produced from different japonica...
Biological species collections are critical for natural product drug discovery programs. However, prioritization of target in massive remains difficult. Here, we introduce an untargeted metabolomics-based workflow that uses MS/MS molecular networking to estimate scaffold-level distribution. As a demonstration, applied the 40 polyporoid fungal species. Nine were prioritized as candidates based on chemical structural and compositional similarity (CSCS) metric. Most selected showed relatively...
The genus Artemisia is an important source of medicines in both traditional and modern pharmaceutics, particularly East Asia. Despite the great benefits herbal medicine, quality assessment methods for these medicinal herbs are lacking. young leaves from species generally used, most have similar morphology, which often leads to adulteration misuse. This study assembled five complete chloroplast genomes three species, two accessions A. gmelinii capillaris, one fukudo. Through comparative...
Taraxacum platycarpum and mongolicum are perennial plants utilized for medicinal purposes in the family Asteraceae. The complete chloroplast genome sequences of two species were characterized by de novo assembly with whole sequencing data. genomes T. 151,307 151,451 bp length, respectively, showed a typical quadripartite structure. both contained same number genes, 79 protein-coding 29 tRNA genes 4 rRNA genes. Phylogenetic analysis indicated that grouped officinale, all which sister...
Two new dimeric selaginellins, diselaginellins C and D (1 2), a unusual derivative, selapiginellin A (4), selaginpulvilin U (5), known diselaginellin (3), were isolated from Selaginella tamariscina (P. Beauv.) Spring. Among these compounds, (4) is the first naturally occurring compound comprising an ether-linked dimer of selaginellin selaginpulvilin. The absolute configurations 1, 2, 4 elucidated by spectroscopic data analyses. Compound 5 was found to regulate mRNA expression low-density...
A new phenolic compound (1) and together with 12 known compounds-eight flavonoids (2 ∼ 9), two compounds (10 11) benzoic acid (12 13)-were isolated from Phedimus middendorffianus (Maxim.). The structures of all were determined on the basis spectroscopic (MS NMR) analyses. Compounds 4, 5, 7 11 13 showed anti-proliferative activities against MCF-7 than PC-3 cell line. Also significant cytotoxic cancer lines, MCF-7.
Liriope platyphylla F.T. Wang & Tang and Ophiopogon japonicus (Thunb.) Ker Gawl are morphologically similar perennial herbaceous plants belonging to the Asparagaceae family used as evergreen ornamental well for medicinal purposes. Complete plastid genomes (plastomes) 45S nuclear ribosomal DNA (45S rDNA) sequences were obtained from two L. accessions one O. using low-coverage, whole-genome data. Phylogenomic analysis plastomes or rDNA of three showed identical topology. Comparative...
Hop (Humulus lupulus L., Cannabaceae) is widely distributed in Kosovo and known to be rich valuable secondary metabolites. This study aimed evaluate the natural variability xanthohumol, α-acids, β-acids, total phenolic content (TPC), flavonoid (TFC), antioxidant activity (2.2-diphenyl-1-picrylhydrazyl (DPPH) ferric reducing power (FRAP)) within wild hops Kosovo. Female inflorescences from 21 populations were collected, dried, then extracted using methanol. The TPC, TFC, activities analysed a...
The structural determination of natural products (NPs) can be arduous due to sample heterogeneity. This often demands itera-tive purification processes and characterization complex molecules that may only available in miniscule quantities. Microcrystal electron diffraction (microED) has recently shown promise as a method solve crystal structures NPs from nanogram quantities analyte. However, its implementation NP discovery remains hampered by throughput purity requirements akin traditional...
Hop (Humulus lupulus L., Cannabaceae) is widely distributed in Kosovo and known to be rich valuable secondary metabolites. This study aimed evaluate the natural variability xanthohumol, α-acids, β-acids, total phenolic content (TPC), flavonoid (TFC), antioxidant activity (2.2-diphenyl-1-picrylhydrazyl (DPPH) ferric reducing power (FRAP)) within wild hops Kosovo. Female inflorescences from 21 populations were collected, dried, then extracted using methanol. The TPC, TFC, activities analysed a...
Background : Plants belonging to 5 species of the genus Eleutherococcus are currently distributed in Korean peninsula. The traditional medicine ‘Ogapi’, derived from sessiliflorus and other related species, ‘Gasiogapi’, senticosus, frequently mixed up marketed. Therefore, accurated identification their origins urgently required. Methods Results Candidate genes nuclear ribosomal DNA (nrDNA) chloroplast (cpDNA) plants were analyzed. Whereas nrDNA-internal transcribed spacer (ITS) regions...
Plants within the genus Selaginella are widely distributed around globe including more than 700 species [1]. Among genus, aerial part of tamariscina (Beauv.) Spring has been used as human cancer traditionally. Hundreds compounds biflavonoids, selaginellins and terpenoids have reported from S.tamariscina. However, chemical constituents roots rarely studied owing to its difficulty for collection, compared other parts this plant. The recently rare naturally occurring fluorene derivatives...
Selaginellins, unique pigments found in the genus Selaginella, were reported as potent phosphodiesterase-4 (PDE4) inhibitors recent studies. To isolate diverse natural selaginellin derivatives, we applied a MS/MS based molecular networking strategy enhanced by silico structural annotation to Selaginella tamariscina extracts. It led prioritization of chromatographic peaks predicted previously unknown derivatives. As result, could ten compounds containing two unusual analogs with...