A5049295416- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- Pneumocystis jirovecii pneumonia detection and treatment
- Essential Oils and Antimicrobial Activity
- interferon and immune responses
- HIV/AIDS drug development and treatment
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Biochemical and Molecular Research
- Pharmacological Effects of Natural Compounds
- Herbal Medicine Research Studies
- Enzyme Structure and Function
- SARS-CoV-2 detection and testing
- Pneumonia and Respiratory Infections
- Hepatitis B Virus Studies
- Piperaceae Chemical and Biological Studies
- vaccines and immunoinformatics approaches
- Mosquito-borne diseases and control
- Cytomegalovirus and herpesvirus research
- Phytochemistry and Biological Activities
- Pharmacological Receptor Mechanisms and Effects
- Hepatitis C virus research
- Protein Structure and Dynamics
Children's Healthcare of Atlanta
2020-2024
Emory University
2020-2024
Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or CoV-2). Some reports claimed certain nucleoside analogs to be active against CoV-2 and thus needed confirmation. Here, we evaluated panel of compounds identified novel with antiviral activity HCoV-OC43 while ruling out others. Of significance, sofosbuvir demonstrated no effect CoV-2, its triphosphate did not inhibit RNA polymerase.
Remdesivir, a monophosphate prodrug of nucleoside analog GS-441524, is widely used for the treatment moderate to severe COVID-19. It has been suggested use GS-441524 instead remdesivir in clinic and new inhalation formulations. Thus, we compared anti-SARS-CoV-2 activity Vero E6, CCL-81, Calu-3, Caco-2 cells, anti-HCoV-OC43 Huh-7 cells. We also cellular pharmacology these two compounds Caco-2, Huh-7, 293T, BHK-21, 3T3 human airway epithelial (HAE) cells. Overall, exhibited greater potency...
Abstract Throughout the SARS-CoV-2 pandemic, use of botanical dietary supplements in United States has increased, yet their safety and efficacy against COVID-19 remains underexplored. The Quave Natural Product Library is a phylogenetically diverse collection fungal natural product extracts including popular supplement ingredients. Evaluation 1867 18 compounds for virus spike protein binding to host cell ACE2 receptors pseudotyped system identified 310 derived from 188 species across 76...
Most repurposed drugs have proved ineffective for treating COVID-19. We evaluated median effective and toxic concentrations (EC50, CC50) of 49 drugs, mostly from previous clinical trials, in Vero cells. Ratios reported unbound peak plasma concentrations, (Cmax)/EC50, were used to predict the potential vivo efficacy. The 20 with highest ratios retested human Calu-3 Caco-2 cells, their CC50 was determined an expanded panel cell lines. Many inactive Antivirals controlled trials had Cmax/EC50 ≥...
Over the past decades, both 4′-modified nucleoside and carbocyclic analogs have been under spotlight as several compounds from either family showed anti-HIV, HCV, RSV or SARS-CoV-2 activity. Herein, we designed combining these two features report synthesis of a series novel 4′-substituted uracil derivatives along with their corresponding monophosphate prodrugs. These were successfully prepared in 19 to 22 steps commercially available (-)-Vince lactam evaluated against panel RNA viruses...
Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molnupiravir, ester prodrug form of N4-hydroxycytidine (NHC), was recently emergency-use approved for treatment early SARS-CoV-2 infections. Herein, we report synthesis evaluation a series novel NHC analogs.
The design and synthesis of antiviral compounds were guided by computationally predicted data against highly conserved non-structural proteins (Nsps) the SARS-CoV-2 coronavirus. Chromenephenylmethanone-1 (CPM-1), a novel biphenylpyran (BPP), was selected from unique natural product library based on in silico docking scores to coronavirus Nsps with high specificity methyltransferase protein (2′-O-MTase, Nsp10–16), which is responsible for viral mRNA maturation host innate immune response...
Yellow fever virus (YFV) is a potentially lethal, zoonotic, blood-borne flavivirus transmitted to humans and non-human primates by mosquitoes. Owing multiple deadly epidemics, the WHO classifies YFV as "high impact, high threat disease" with resurgent epidemic potential. At present, there are no approved antiviral therapies combat infection. Herein we report on 2'-halogen-modified nucleoside analogs potential anti-YFV agents. Of 11 compounds evaluated, three showed great promise low...
The examination of biodiversity across the world has historically been a critical part drug development and led to discovery common medications for many medical issues including pain management, cancer, heart disease, infections. During SARS-CoV-2 pandemic, use natural supplements in United States increased. efficacy these products prevent infection safety their remains unexplored; therefore, more research must be done determine which have antiviral properties. Quave Natural Product Library...