A5034403065- Fungal and yeast genetics research
- Plant Pathogens and Fungal Diseases
- Protist diversity and phylogeny
- Plant-Microbe Interactions and Immunity
- Chromosomal and Genetic Variations
- Legume Nitrogen Fixing Symbiosis
- Plant Disease Resistance and Genetics
- Genomics and Chromatin Dynamics
- Genomics and Phylogenetic Studies
- Grouting, Rheology, and Soil Mechanics
- Fungal Biology and Applications
- Mycotoxins in Agriculture and Food
- Yeasts and Rust Fungi Studies
- DNA Repair Mechanisms
- French Language Learning Methods
- Insect symbiosis and bacterial influences
- Civil and Structural Engineering Research
- Nematode management and characterization studies
- Geotechnical Engineering and Soil Stabilization
Université Paris Cité
2024
Institut Pasteur
2020-2024
Terra
2022
Institut de Biologie Intégrative de la Cellule
2018-2021
CEA Paris-Saclay
2019-2021
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2019-2021
Centre National de la Recherche Scientifique
2019-2021
Université Paris-Saclay
2019-2021
Université Paris-Sud
2019
Abstract Background Selective gene silencing is key to development. It generally accepted that H3K27me3-enriched heterochromatin maintains transcriptional repression established during early development and regulates cell fate. Conversely, H3K9me3-enriched prevents differentiation but constitutes protection against transposable elements. We exploited the fungus Podospora anserina , a valuable alternative higher eukaryote models, question biological relevance functional interplay of these two...
DNA methyltransferases are ubiquitous enzymes conserved in bacteria, plants and opisthokonta. These enzymes, which methylate cytosines, involved numerous biological processes, notably development. In mammals higher plants, methylation patterns established maintained by the cytosine (DMTs) essential to zygotic fungi, some members of an extensively fungal-specific methyltransferase class both mediators Repeat Induced Point mutation (RIP) genome defense system key players sexual reproduction....
In eukaryotes, repetitive DNA can become silenced de novo, either transcriptionally or post-transcriptionally, by processes independent of strong sequence-specific cues. The mechanistic nature such remains poorly understood. We found that in the fungus Neurospora crassa , novo initiation both transcriptional and post-transcriptional silencing was linked to perturbed chromatin, which produced experimentally aberrant activity transcription factors at tetO operator array. Transcriptional...
ABSTRACT In eukaryotes, repetitive DNA can become silenced de novo , either transcriptionally or post-transcriptionally, by processes independent of strong sequence-specific cues. The mechanistic nature such remains poorly understood. We found that in the fungus Neurospora crassa initiation both transcriptional and post-transcriptional silencing was linked to perturbed chromatin, which produced experimentally aberrant activity transcription factors at tetO operator array. Transcriptional...
Abstract Selective gene silencing is key to development. The H3K27me3 enriched heterochromatin maintains transcription repression established during early development and regulates cell fate. Conversely, H3K9me3 prevents differentiation but constitutes a permanent protection against transposable element. We exploited the fungus Podospora anserina , valuable alternative higher eukaryote models question biological relevance interplay of these two distinct conformations. found that...
Abstract DNA methyltransferases are ubiquitous enzymes conserved in bacteria, plants and opisthokonta. These enzymes, which methylate cytosines, involved numerous biological processes, notably development. In mammals higher plants, methylation patterns established maintained by the cytosine (DMTs) essential to zygotic fungi, some members of an extensively fungal-specific methyltransferase class both mediators Repeat Induced Point mutation (RIP) genome defense system key players sexual...
ABSTRACT Repeat-induced point mutation (RIP) is a genetic process that creates cytosine-to-thymine (C-to-T) transitions in duplicated genomic sequences fungi. RIP detects duplications irrespective of their origin, particular sequence, coding capacity, or positions. Previous studies suggested involves cardinally new mechanism sequence recognition operates on intact double-stranded DNAs. In the fungus Neurospora crassa , can be mediated by putative C5-cytosine methyltransferase (CMT) RID...