A5087579652- Telomeres, Telomerase, and Senescence
- Metabolomics and Mass Spectrometry Studies
- Genetics, Aging, and Longevity in Model Organisms
- Nutritional Studies and Diet
- Food Security and Health in Diverse Populations
- Vitamin C and Antioxidants Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nutrition, Genetics, and Disease
- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Long-Term Effects of COVID-19
- Agriculture Sustainability and Environmental Impact
- Medicinal Plants and Neuroprotection
- Cholesterol and Lipid Metabolism
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Fatty Acid Research and Health
- Microplastics and Plastic Pollution
- Global Public Health Policies and Epidemiology
- Lipid metabolism and biosynthesis
- Exercise and Physiological Responses
- Gut microbiota and health
- Advanced Chemical Sensor Technologies
- Adrenal Hormones and Disorders
University of Crete
2018-2025
Athens Medical Center
2019-2024
The General Hospital of Heraklion "Venizeleio-Pananio"
2020
Telomere length, a marker of cellular aging, decreases with age and it has been associated aging‑related diseases. Environmental factors, including diet lifestyle affect the rate telomere shortening which can be reversed by telomerase. Telomerase activation natural molecules suggested to an anti‑aging modulator that play role in treatment This study aimed investigate effect compounds on telomerase activity human peripheral blood mononuclear cells (PBMCs). The tested included Centella...
Autoimmune diseases (ADs) are rapidly increasing worldwide and accumulating data support a key role of disrupted metabolism in ADs. This study aimed to identify an improved combination Total Fatty Acids (TFAs) biomarkers as predictive factor for the presence autoimmune diseases. A retrospective nested case-control was conducted 403 individuals. In case group, 240 patients diagnosed with rheumatoid arthritis, thyroid disease, multiple sclerosis, vitiligo, psoriasis, inflammatory bowel other...
Telomeres are nucleotide tandem repeats located at the tip of eukaryotic chromosomes that maintain genomic integrity. The gradual shortening telomeres leads to cellular senescence and apoptosis, a key mechanism aging age‑related chronic diseases. Epigenetic factors, such as nutrition, exercise tobacco can affect rate which shorten modify risk developing In this study, we evaluated effects combination nutraceutical supplements (NS) on telomere length (TL) in healthy volunteers with no medical...
Abstract Background Dietary habits have a profound influence on the metabolic activity of gut microorganisms and their health. Concerns been raised as to whether consumption foodstuffs contaminated with pesticides can contribute development chronic disease by affecting microbiome. We performed first pesticide biomonitoring survey British population, subsequently used results perform association study microbiome composition function from TwinsUK registry. Methods exposure 186 common...
Telomeres, the protective caps of chromosomes, shorten with age, as telomerase, enzyme responsible for compensation telomere erosion, is inactive in majority cells. Telomere shortening and subsequent cell senescence lead to tissue aging age‑related diseases. Neurodegenerative disorders, characterized by progressive loss neurons among other hallmarks aged tissue, poor cognitive function, have been associated a short length. Thus, telomerase activity has emerged therapeutic target, novel...
Fatty acids (FAs) play critical roles in health and disease. The detection of FA imbalances through metabolomics can provide an overview individual's status, particularly as regards chronic inflammatory disorders. In this study, we aimed to establish sensitive reference value ranges for targeted plasma FAs a well‑defined population healthy adults. Plasma samples were collected from 159 participants admitted outpatients. A total 24 analyzed using gas chromatography‑mass spectrometry,...
Telomeres are major contributors to cell fate and aging through their involvement in cycle arrest senescence. The accelerated attrition of telomeres is associated with aging‑related diseases, agents able maintain telomere length (TL) telomerase activation may serve as potential treatment strategies. aim the present study was assess potency a novel activator on TL activity vivo. administration nutraceutical formulation containing Centella asiatica extract, vitamin C, zinc D3 18‑month‑old rats...
Chronic obstructive lung disease (COLD) is a group of airway diseases, previously known as emphysema and chronic bronchitis. The heterogeneity COLD does not allow early diagnosis leads to increased morbidity mortality. increasing number incidences stresses the need for precision medicine approaches that are specific patient. Metabolomics an emerging technology allows discrimination metabolic changes in cell result environmental factors genetic background. Thus, quantification metabolites...
Introduction: Telomere length (TL) is causally related to aging and several age-related diseases. Specifically, the abundance of short telomeres rate telomere shortening are strong determinants cell homeostasis. Thus, tools for analyzing manipulating TL data can vastly improve research focused on aging. Aim: In this study, we developed a semi-automated worksheet, BIOTEL, generate individual group statistics provide crude estimation biological age. Results: Data from Length Database Project...
Psoriasis is a chronic, immune-mediated skin condition with significant metabolic complications. Although lipid metabolism linked to its pathogenesis, reliable biomarkers and the impact of modifiable factors remain underexplored. The aim present study was identify potential biomarkers, affected networks, assess role dietary lifestyle in psoriasis. Plasma samples from 56 patients psoriasis 49 healthy controls were analyzed, as part Metabolic Biomarkers Hashimoto's Thyroiditis (METHAP)...
Non-communicable diseases (NCDs), known as chronic diseases, significantly impact patients' quality of life (QoL) and increase medical expenses. The majority risk factors are modifiable, metabolomics has been suggested a promising strategy for their evaluation, though real-world data scarce. This study evaluated the QoL improvement cost-effectiveness metabolomics-based treatment NCDs, aiming to restore metabolic dysfunctions nutritional deficiencies. We performed pre-post intervention...
Dear Editors, Reading the recent article by McAuliffe et al ,1 we were interested in approach presented to target micronutrient deficiencies of high-risk population for COVID-19 and empower their immune system against infection.1 The authors present evidence on central role selected nutrients function respiratory infections while showing clinical data from studies using prophylactic supplementation. However, have not yielded conclusive results beneficial nutrient supplementation support...
Hashimoto's thyroiditis and psoriasis are inflammatory disorders that significantly impact patients' quality of life, stressing the need for novel biomarkers early diagnosis. This randomized clinical trial (NCT04693936) aims to identify thyroiditis' psoriasis' metabolic investigate effect environmental factors on disease-related imprint life. Patients with thyroiditis, patients psoriasis, healthy individuals aged 18-60 will be recruited, enrolled according eligibility criteria (medical...
Telomere length is an important biomarker in a number of diseases, including male infertility. A decreased telomere has been reported several diseases and shortening may occur due to aging, telomerase activity, oxidative stress or cell division. In recent years, studies have indicated that males with infertility shorter sperm than fertile males. Sperm associated through mechanisms, the apoptosis spermatozoa, motility, low count, incorrect chromosomal pairing movement during meiosis, failed...