A5015256508- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Insect and Pesticide Research
- Synthesis and biological activity
- Parasites and Host Interactions
- Synthesis and Biological Evaluation
- Silymarin and Mushroom Poisoning
- Clostridium difficile and Clostridium perfringens research
- Plant and animal studies
- HIV/AIDS drug development and treatment
- Insect and Arachnid Ecology and Behavior
- Synthesis and Characterization of Heterocyclic Compounds
- Phytochemical compounds biological activities
- Synthesis and bioactivity of alkaloids
Universidad Complutense de Madrid
2016-2023
Research Institute Hospital 12 de Octubre
2016-2019
Abstract Infected dogs are the main reservoir of zoonotic visceral leishmaniasis, a widespread parasitic disease caused by Leishmania infantum . Therefore, control canine infections is required to reduce incidence human cases. Disease outcome in depends on fine balance between parasite virulence and efficacy immune system. Thus, knowledge early response could yield relevant information for diagnosis follow-up. In our study, 20 Beagle were intravenously infected with 10 8 amastigotes fresh...
We report the discovery of new 4-hydroxyphenyl phosphonium salt derivatives active in submicromolar range (EC50 from 0.04 to 0.28 μM, SI > 10) against protozoan parasite Leishmania donovani. The pharmacokinetics and vivo oral efficacy compound 1 [(16-(2,4-dihydroxyphenyl)-16-oxohexadecyl)triphenylphosphonium bromide] a mouse model visceral leishmaniasis were established. Compound reduced load spleen (98.9%) liver (95.3%) infected mice after an dosage four daily doses 1.5 mg/kg. Mode action...
Abstract Background Zoonotic visceral leishmaniasis by Leishmania infantum is a first-order pathology in canine veterinary clinics endemic areas. Moreover, infections are considered the main reservoir for human disease; despite their importance control of disease within One Health approach, no scientometric study has been published. Aims included analyzing impact (CanL) on scientific literature, drugs or combinations used, trends period from 2000 to 2020 and efficacy criteria employed....
Flavonolignans from the seeds of milk thistle (Silybum marianum) have been extensively used in folk medicine for centuries. Confirmation their properties as hepatoprotective, antioxidant and anticancer has obtained using standardized extracts purified flavonolignans. Information on potential effect Leishmania is very scarce. We investigated silymarin, silybin related flavonolignans multiplication promastigotes vitro ex vivo intracellular amastigotes L. infantum (Li) donovani (Ld), causative...
Chemical modulation of the flavonol 2-(benzo[d][1,3]dioxol-5-yl)-chromen-4-one (1), a promising anti-Trypanosomatid agent previously identified, was evaluated through phenotypic screening approach. Herein, we have performed structure–activity relationship studies around hit compound 1. The pivaloyl derivative (13) showed significant anti-T. brucei activity (EC50 = 1.1 μM) together with selectivity index higher than 92. early in vitro ADME-tox properties (cytotoxicity, mitochondrial toxicity,...
Abstract Leishmania infantum is the etiological agent of zoonotic visceral leishmaniasis. In endemic areas, canine infections are considered main source infection for human populations. Therefore, any control leishmaniasis must include infections. Chemotherapy inadequate and immunoprophylaxis has important limitations. Reports on response infected dogs abundant but no clear picture immune events emerged. To shed some light these shortcomings specific IgG subclass was followed in 20 Beagle...
Visceral leishmaniasis (VL) is the most severe form of all leishmanial infections and caused by infection with protozoa Leishmania donovani infantum. This parasitic disease occurs in over 80 countries its geographic distribution on rise. Although interaction between intestinal microbiome immune response has been established several pathologies, it not widely studied leishmaniasis. The Syrian hamster advanced laboratory model for developing vaccines new drugs against VL. In study reported...
Visceral leishmaniasis (VL), a vector-borne parasitic disease caused by Leishmania donovani and L. infantum (Kinetoplastida), affects humans dogs, being fatal unless treated. Miltefosine (MIL) is the only oral medication for VL considered first choice drug when resistance to antimonials present. Comorbidity comedication are common in many affected patients but relationship between microbiome composition, drugs administered their pharmacology still unknown. To explore effect of clindamycin on...
Abstract Background: Zoonotic visceral leishmaniasis by Leishmania infantum is a first order pathology in veterinary clinics of dogs endemic areas. Moreover, canine infections are considered the main reservoir for human disease; despite their importance control disease within One Health approach no scientometric study has been published. Aims included impact (CanL) on scientific literature, drugs or combinations used, trends period from 2000-2020 and efficacy criteria employed. Methods: A...
Abstract Background Zoonotic visceral leishmaniasis by Leishmania infantum is a first order pathology in veterinary clinics of dogs endemic areas. Moreover, canine infections (CanL) are considered the main reservoir for human disease. Despite importance CanL control diseases within One Health approach no scientometric study has been published. Aims included impact on scientific literature, drugs or combinations used, trends period from 2000-2017 and efficacy criteria employed. Methods A Web...