A5057282805- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Nonlinear Optical Materials Studies
- Photochromic and Fluorescence Chemistry
- Luminescence and Fluorescent Materials
- Carbon Dioxide Capture Technologies
- Synthesis and biological activity
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Origins and Evolution of Life
- Metal-Organic Frameworks: Synthesis and Applications
- Silicon Nanostructures and Photoluminescence
- Covalent Organic Framework Applications
- Nanoplatforms for cancer theranostics
- Bone Tissue Engineering Materials
- Membrane Separation and Gas Transport
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Sensors
- Synthesis and Biological Evaluation
- Gas Sensing Nanomaterials and Sensors
- Traditional and Medicinal Uses of Annonaceae
- T-cell and B-cell Immunology
- Catalytic Processes in Materials Science
- Computational Drug Discovery Methods
- Molecular Sensors and Ion Detection
Instituto de Química Médica
2018-2025
Institut des Sciences Moléculaires
2014-2024
Université de Bordeaux
2013-2024
École Nationale Supérieure de Chimie de Montpellier
2018-2023
Université de Montpellier
2019-2023
Centre National de la Recherche Scientifique
2013-2023
Institut Charles Gerhardt Montpellier
2018-2023
Centro de Astrobiología
2020-2023
Centre Occitanie-Montpellier
2019
Canadian Nautical Research Society
2015
Porous silicon nanoparticles (pSiNP), modified to target dendritic cells (DC), provide an alternate strategy for the delivery of immunosuppressive drugs. Here, we aimed develop a DC-targeting pSiNP displaying c-type lectin, cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), and CD11c monoclonal antibodies. The in vivo tracking these fluorescent was assessed both C57BL/6 mice common marmosets (Callithrix jacchus) by intravenous injection (20 mg/kg). Rapamycin...
We present a modular approach to photo-labile protecting groups based on photoinduced electron transfer, providing high sensitivity two-photon excitation.
New caffeine analogues, derived from theobromine and theophylline, exhibit potent selective acetylcholinesterase inhibition, positioning them as promising lead compounds for the development of novel drugs targeting neurodegenerative diseases.
In this work, we have described the characterization of hybrid silica nanoparticles 50 nm size, showing outstanding size homogeneity, a large surface area, and remarkable CO2 sorption/desorption capabilities. A wide battery techniques was conducted ranging from spectroscopies such as: UV-Vis IR, to microscopies (SEM, AFM) isotherms, thus with purpose full material. The bare SiO2 (50 nm) modified 3-aminopropyl (triethoxysilane), APTES@SiO2 nm), show sequestration enhancement compared pristine...
The concept of using two-photon excitation in the NIR for spatiotemporal control biological processes holds great promise. However, its use delivery nucleic acids has been very scarcely described and reported procedures are not optimal as they often involve potentially toxic materials irradiation conditions. This work prepares a simple system made biocompatible porous silicon nanoparticles (pSiNP) safe siRNA photocontrolled gene silencing cells upon excitation. PSiNP linked to an azobenzene...
Abstract Tandem uncaging systems in which a two‐photon absorbing module and cage moiety, linked via phosphorous clip, that act together by Förster resonance energy transfer (FRET) have been developed. A library of these compounds, using different linkers cages (7‐nitroindolinyl or nitroveratryl) has synthesized. The investigation their absorption properties demonstrates the scope versatility engineering strategy towards efficient reveals surprising cooperative topological effects....
Tandem systems allowing enhanced two-photon (2P) absorption in a wavelength range permitting coupling of the primary excitation by energy transfer to an intramolecular cage known have fragmentation properties suited photolysis neuroscience is demonstrated lead 10-fold improvement 2P cross-section at experimentally compatible wavelengths.
Carbon dioxide solid sorbents produced from mesoporous functionalized silica microparticles (SBA-15) have been investigated (i) theoretically using density functional theory and (ii) evaluated empirically for assessing their CO2 adsorption capacity. Two different families of organosilyl groups tested possessing a common anchoring group (silanol), in one extreme, but bearing two types sensitive the other extreme; hyperbranched polymeric PAMAM moieties, carrying multiple −NH2 groups,...
A series of dyads that combine a photolabile protecting group (PPG) 4,5-dimethoxy-2-nitrobenzyl and different bis-donor or bis-acceptor dissymmetric chromophores acting as two-photon (2P) absorbers were synthesized. Even for low energy transfer efficiency from the 2PA subunit to uncaging one, improvement 2P sensitivity in NIR is achieved compared isolated PPG. Moreover enhancement response by tuning electronic dissymmetry arrangement complementary subunits dyads.
Scheme of gene transfer into a cell nucleus using porous silicon nanoparticle based non viral vector.
We report the discovery of new 4-hydroxyphenyl phosphonium salt derivatives active in submicromolar range (EC50 from 0.04 to 0.28 μM, SI > 10) against protozoan parasite Leishmania donovani. The pharmacokinetics and vivo oral efficacy compound 1 [(16-(2,4-dihydroxyphenyl)-16-oxohexadecyl)triphenylphosphonium bromide] a mouse model visceral leishmaniasis were established. Compound reduced load spleen (98.9%) liver (95.3%) infected mice after an dosage four daily doses 1.5 mg/kg. Mode action...
The SAR of 4-hydroxybenzaldehyde inhibitors the trypanosome alternative oxidase (TAO), a critical enzyme for respiration bloodstream forms trypanosomes, was investigated. Replacing aldehyde group with methyl ester resulted in 10-fold increase TAO inhibition and activity against T. brucei. Remarkably, two analogues containing 2-hydroxy-6-methyl scaffold (9e 16e) displayed single digit nanomolar inhibition, which constitute most potent 4-alkoxybenzoic acid derivatives described to date. 9e...
The role of minerals in the origin life and prebiotic evolution remains unknown controversial. Mineral surfaces have potential to facilitate polymerization due their ability adsorb concentrate biomolecules that subsequently can catalyse reactions; however, precise nature interaction between mineral host guest biomolecule still needs be understood. In this context, we spectroscopically characterized, using infrared, X-ray photoemission spectroscopy (XPS) diffraction (XRD) techniques,...
A single layer of silica nanoparticles with an average size ∼200 nm was deposited over the surface pristine gold wafers, aided by (3-mercaptopropyl)trimethoxysilane.
The trypanosome alternative oxidase (TAO), a mitochondrial enzyme involved in the respiration of bloodstream form trypomastigotes Trypanosoma brucei, is validated drug target against African trypanosomes. Earlier series TAO inhibitors having 2,4-dihydroxy-6-methylbenzoic acid scaffold ("head") and triphenylphosphonium or quinolin-1-ium cation as mitochondrion-targeting group ("tail") were shown to be nanomolar enzymatic cellular assays. We investigated here effect different cations other...
"Tandem" uncaging systems, in which a photolabile protecting group (PPG) is sensitized by an energy-harvesting antenna, may increase the photosensitivity of PPGs several orders magnitude for two-photon (2P) photorelease. Yet, they remain poorly accessible because arduous multi-step synthesis. In this work, we design efficient tandem systems (i) using convenient assembly building blocks relying on click chemistry, (ii) introducing H-bonding induced proximity thus facilitating (iii)...
Nanostructured porous silicon (pSi) is a synthetic silicon-based material. Its biocompatibility and bioresorbability in body fluids make pSi an appealing biomaterial for tissue engineering, with surfaces characteristics facilitating human cell adhesion differentiation. The resorption kinetics of such biomaterials crucial vivo bone regeneration, order to adapt formation, control the release loaded bioactive molecules. We investigated as scaffold emphasis on release. PSi particles chips were...
We have recently reported on the development and trypanocidal activity of a class inhibitors Trypanosome Alternative Oxidase (TAO) that are targeted to mitochondrial matrix by coupling lipophilic cations via C14 linkers enable optimal interaction with enzyme's active site. This strategy resulted in much-enhanced anti-parasite effect, which we ascribed greater accumulation compound at location target protein, i.e. mitochondrion, but date this localization has not been formally established....