A5061479574- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Microbial infections and disease research
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- Complement system in diseases
- Insect and Pesticide Research
- Insect-Plant Interactions and Control
- Platelet Disorders and Treatments
- Insect Pest Control Strategies
- Leptospirosis research and findings
- Veterinary medicine and infectious diseases
- Multiple Myeloma Research and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Diagnosis and treatment of tuberculosis
- Diphtheria, Corynebacterium, and Tetanus
- Infectious Diseases and Tuberculosis
- Viral Infections and Vectors
- T-cell and Retrovirus Studies
- Cutaneous lymphoproliferative disorders research
- Advanced Biosensing Techniques and Applications
Instituto de Salud Carlos III
2016-2025
Centro Nacional de Microbiologia
2016-2025
Banc de Sang i Teixits
2024
Hospital General Universitario de Albacete
2021-2022
Universidad Politécnica de Cartagena
2014-2020
GlaxoSmithKline (Spain)
2019
Junta de Andalucía
2008
Andalusian Institute of Agricultural and Fisheries Research and Training
2008
Acerinox (Spain)
2002
Factor H (FH) is a crucial complement regulator that prevents complement-mediated injury to healthy cells and tissues. This regulatory function can be disrupted by autoantibodies (FHAA), which then leads diseases such as atypical hemolytic uremic syndrome (aHUS) C3 Glomerulopathy (C3G). In pediatric aHUS, the FHAA incidence ~10-15%, although in Indian population, it rises ~50%. The specific regions of FH targeted FHAAs correlate with pathogenic mechanism associated disease. target...
The whitefly Bemisia tabaci Gennadius is a severe pest in many field and greenhouse crops worldwide has developed resistance to insecticides from most chemical classes. ease with which this develops makes it essential incorporate new compounds different modes of action no cross-resistance those previously used into insecticide management strategies. To that end, the systemic effect diamide cyantraniliprole was tested multiresistant, selected populations Q-biotype B. Mediterranean...
Spiromesifen and spirotetramat are novel insecticides belonging to the chemical class of tetronic tetramic acid derivatives. Both compounds have proven very effective against field populations Bemisia tabaci around world. However, several growers recently reported control failures in Spain. Therefore, we studied resistance level these reporting failures. In addition, further selected a spiromesifen-resistant strain study mechanisms involved cross-resistance pattern.All new collected were...
Since March 2020, Spain (along with many other countries) has been severely affected by the ongoing coronavirus disease 19 (COVID-19) pandemic caused rapid spread of a new virus (severe acute respiratory syndrome 2; SARS-CoV-2). As part global efforts to improve surveillance, we investigated how readily SARS-CoV-2 RNA could be detected in environmental samples collected from an isolated rural community high COVID-19 prevalence (6% population 883 inhabitants). The first diagnosis...
The disease produced by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is currently one of primary concerns worldwide. Knowing zoonotic origin and that several animal species, including dogs cats, are susceptible to viral infection, it critical assess relevance pets in this pandemic. Here, we performed a large-scale study on SARS-CoV-2 serological prevalence cats Spain order elucidate their role susceptibility. Samples from animals contact with COVID-19 positive...
Bovine purified protein derivative (bPPD) and avian (aPPD) are widely used for bovine tuberculosis diagnosis. However, little is known about their qualitative quantitative characteristics, which makes standardisation difficult. In addition, bPPD can give false-positive results because of sequence homology between Mycobacterium bovis (M. bovis) M. avium proteins. Thus, the objective this study was to carry out a proteomic characterisation bPPD, aPPD an immunopurified subcomplex from called...
Leishmaniasis is one of the most important neglected zoonosis and remains endemic in at least 88 developing countries world. In addition, anthropogenic environmental changes urban areas are leading to its emergency world wide. Zoonotic leishmaniasis control might only be achieved by an integrated approach targeting both human host animal reservoirs, which certain sylvatic cycles yet identified. Recently, hares have been pointed out as competent reservoirs Leishmania infantum Spain, but role...
Attaining and maintaining the Official Tuberculosis Free status continues to be a challenge when several domestic wild hosts contribute maintenance of Mycobacterium tuberculosis complex (MTC). Local hotspots are sometimes identified in cattle low-prevalence regions. We have, therefore, studied one such hotspot depth order produce an epidemiological diagnosis. Host population size MTC prevalence were estimated selected wildlife livestock, while on-cattle environmental DNA detection was...
In normal human serum (NHS), axenic promastigotes of Crithidia, Phytomonas, and Leishmania trigger complement activation, from 1.2 to 1.8 × 105 C3 molecules are deposited per promastigote within 2.5 min. Leishmania, binding capacity remains constant during in vitro metacyclogenesis. deposition on activated through the classical pathway reaches a 50% maximum after ∼50 s, represents >85% total bound. C1q- C2-deficient sera, cannot activate (CP) unless purified C1q or C2 factors,...
Serum antibody detection has potential as a complementary diagnostic tool in animal tuberculosis (TB) control, particularly multi-host systems. The objective of the present study was to assess specificity (Sp) an enzyme-linked immunosorbent assay (ELISA) based on new multiprotein complex P22 for specific antibodies against Mycobacterium (MTC) four most relevant domestic animals acting MTC hosts: cattle, goat, sheep and pig. We used sera from officially TB-free (OTF) country, Norway, non-OTF...
Wild lagomorphs play a key epidemiological role as reservoirs of Leishmania infantum, causative agent the largest outbreak human leishmaniosis in Europe to date. A large-scale survey study was conducted on wild rabbit (Oryctolagus cuniculus) and Iberian hare (Lepus granatensis) populations Spanish Mediterranean ecosystems evaluate exposure L. infantum investigate potential risk factors associated with this zoonotic parasite. Between 2018 2021, total 631 (471 rabbits 160 hares) were collected...
One of the attractive properties artemisinins is their extremely fast-killing capability, quickly relieving malaria symptoms. Nevertheless, unique benefits these medicines are now compromised by prolonged parasite clearance times and increasing frequency treatment failures, attributed to increased tolerance Plasmodium falciparum artemisinin. This emerging artemisinin resistance threatens undermine effectiveness antimalarial combination therapies. Herein, we describe medicinal chemistry...
To evaluate the efficacy of combination allicin and amphotericin deoxycholate (AmB) in chemotherapy Leishmania infantum infection with final aim reducing dose AmB visceral leishmaniasis. Hamsters were intraperitoneally (ip) infected L. (107 stationary phase promastigotes). On day 45 post-infection animals treated ip (1 or 5 mg/kg/day), (5 mg/kg/day) a + for days. Animals clinically biopathologically monitored antibody response (IgG, IgG1, IgG2) was determined. Parasite burdens estimated by...
In recent decades, habitat change and the intensive management of wild ungulates for hunting have led to an increase in their populations south-central Spain. This implies a higher generation waste, which can favour transmission infectious diseases, including tuberculosis (TB). The aim this study was assess usefulness proper disposal waste as TB control measure boar (Sus scrofa) red deer (Cervus elaphus) during 2008/2009 2016/2017 seasons. Blood samples from 664 934 were obtained 14 game...
Tuberculosis (TB) is a zoonotic infectious disease caused by bacteria belonging to the Mycobacterium tuberculosis complex (MTC), which can affect wide variety of domestic and wild animal species. Although role goats as reservoir MTC has been evidenced, information about circulation strains in this species still very scarce. The aim present study was determine seroprevalence, spatial distribution, risk factors spoligotypes circulating from Andalusia (Southern Spain), Spanish region with...