A5022118573- Layered Double Hydroxides Synthesis and Applications
- Magnesium Oxide Properties and Applications
- Regulation of Appetite and Obesity
- Cannabis and Cannabinoid Research
- Inorganic Chemistry and Materials
- Sleep and Wakefulness Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Genetics and Neurodevelopmental Disorders
- Wnt/β-catenin signaling in development and cancer
- Developmental Biology and Gene Regulation
- Meat and Animal Product Quality
- Nicotinic Acetylcholine Receptors Study
- Neuroinflammation and Neurodegeneration Mechanisms
- Catalysis and Oxidation Reactions
- Diet and metabolism studies
- Axon Guidance and Neuronal Signaling
- Comparative International Legal Studies
- Genomics and Rare Diseases
- Environmental remediation with nanomaterials
- Corneal Surgery and Treatments
- Neurological disorders and treatments
- Nerve injury and regeneration
- Legal processes and jurisprudence
- Adipose Tissue and Metabolism
- Sarcoidosis and Beryllium Toxicity Research
Universidad Complutense de Madrid
2004-2023
Instituto Cajal
2011-2023
Consejo Superior de Investigaciones Científicas
2022-2023
Instituto de Salud Carlos III
2023
Biomedical Research Networking Center on Neurodegenerative Diseases
2023
Centro de Biología Molecular Severo Ochoa
2014-2019
Universidad Autónoma de Madrid
2014-2019
Centre for Biomedical Network Research on Rare Diseases
2014-2018
Centro de Investigación Biomédica en Red
2014
University of Córdoba
1997-2011
Lafora progressive myoclonus epilepsy (Lafora disease) is a fatal autosomal recessive neurodegenerative disorder characterized by the presence of glycogen-like intracellular inclusions called bodies. The vast majority patients carry mutations in either EPM2A or EPM2B genes, encoding laforin, glucan phosphatase, and malin, an E3 ubiquitin ligase, respectively. Although precise physiological role these proteins not fully understood, work past years has established link between glycogen...
Ghrelin is an endogenous regulator of energy homeostasis synthesized by the stomach to stimulate appetite and positive balance. Similarly, endocannabinoid system part our internal machinery controlling food intake expenditure. Both peripheral central mechanisms regulate CB1-mediated control a functional relationship between hypothalamic ghrelin cannabinoid CB1 receptor has been proposed. First all, we investigated brain actions on in rats with different metabolic status (negative or...
Abstract Changes in the transcription factor (TF) expression are critical for brain development, and they may also underlie neurodevelopmental disorders. Indeed, T-box brain1 (Tbr1) is a TF crucial formation of neocortical layer VI, mutations microdeletions that gene associated with malformations human cerebral cortex, alterations accompany autism spectrum disorder (ASD). Interestingly, Tbr1 upregulation has been related to occurrence ASD-like symptoms, although limited studies have...
The mammalian dorsal telencephalic neuroepithelium develops-from medial to lateral-into the choroid plaque, cortical hem, hippocampal primordium and isocortex under influence of Bmp, Wnt Notch signaling. Correct development requires a tight coordination extent/duration these signals, but identification possible molecular coordinators is still limited. Here, we postulated that Secreted Frizzled Related Protein 1 (Sfrp1), multifunctional regulator signaling strongly expressed during early...
Hydrotalcite-like compounds containing (a) MgII, AlIII and VIII in the layers carbonate interlayers, or (b) MgII decavanadate have been synthesized characterized using powder X-ray diffraction, thermal analysis, FTIR spectroscopy. temperature-programmed reduction, specific surface-area determination. The crystalline phases formed after calcination air at 700 °C identified these same experimental techniques. It has found that nature of precursor determines Mg–V–O formed; thus, when starting...
The thermal decomposition of hydrotalcite-like materials containing Zn(II), Fe(III), and Al(III) is studied. One these samples contains zinc aluminum in the brucite-like layers, while iron incorporated as hexacyanoferrate(III) anions interlayer space. A second set with Fe/Al atomic ratios range 0−1 zinc, iron, cations layer carbonate anion. When started from latter precursors, X-ray diffraction only detects formation ZnO after calcination at 400−600 °C, absorption spectra recorded Fe Al−K...
Durante la producción de jugo naranja se producen grandes cantidades desechos, cerca del 50% peso total fruta. México es uno los mayores productores a nivel mundial, y deben considerar estudiar nuevas técnicas rentables amigables con el medio ambiente para reducir emisión gases efecto invernadero atmósfera debido residuos naranja. Los contenidos permitidos metales pesados como Cd II son frecuentemente excedidos en cuerpos agua subterráneos superficiales procesos antropogénicos naturales,...
Insulin-like growth factor-I (IGF-I) exerts multiple actions, yet the role of IGF-I from different sources is poorly understood. Here, we explored functional and behavioral consequences conditional deletion Igf-I in nervous system ( Δ/Δ ), demonstrated that long-term potentiation was impaired hippocampal slices. Moreover, mice showed spatial memory deficits Morris water maze, significant sex-dependent differences displayed by Ctrl/Ctrl disappeared open field rota-rod tests. Brain...
En paralelo al surgimiento del derecho internacional de inversiones extranjeras se perfecciona todo un sistema solución controversias que cuenta con centros arbitraje dedicados exclusivamente a la resolución conflictos en materia inversión, como es el Centro Internacional Arreglo Disputas relativas Inversiones. Este Centro, conocido por sus siglas CIADI español, ICSID inglés y CIRDI francés, una organización autónoma creada través Convenio Washington sobre Diferencias Inversiones entre...
Lopez-Moreno, J.A.1 2; Scherma, M.3; Fattore, L.3; Moreno, G.1; González-Cuevas, Crespo, I.1; Gómez de Heras, R.1; Rodríguez Fonseca, F.4; Fratta, W.3; Navarro, M.1 Author Information