A5075796885- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Antifungal resistance and susceptibility
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Vaccine Coverage and Hesitancy
- Sinusitis and nasal conditions
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- Immunotherapy and Immune Responses
- Food Allergy and Anaphylaxis Research
- Enzyme Production and Characterization
- Antimicrobial Peptides and Activities
- Protease and Inhibitor Mechanisms
- Blood donation and transfusion practices
Universitätsmedizin Greifswald
2020-2024
TÜV Rheinland (Germany)
2023
Paul Ehrlich Institut
2023
COVID-19 vaccines are highly effective in inducing protective immunity. While the serum antibody response to vaccination has been studied depth, our knowledge of underlying plasmablast and memory B cell (Bmem) responses is still incomplete. Here, we determined a naïve population contrasted it with single influenza primed cohort. In addition, analyzed against four endemic human coronaviruses (HCoVs).
Staphylococcus aureus is an opportunistic pathogen that can cause life-threatening infections, particularly in immunocompromised individuals. The high-level virulence of S. largely relies on its diverse and variable collection factors immune evasion proteins, including the six serine protease-like proteins SplA to SplF. Spl are expressed by most clinical isolates aureus, but little known about molecular mechanisms which these modify host's response for benefit bacteria. Here, we identify...
In cystic fibrosis (CF) infectious and allergic airway inflammation cause pulmonary exacerbations that destroy the lungs. Staphylococcus aureus is a common long-term colonizer of recurrent infections in CF. The pathogen also associated with respiratory allergy; especially staphylococcal serine protease-like proteins (Spls) can induce type 2 immune responses humans mice. We measured serum IgE levels specific to 7 proteases S. by ELISA, targeting 5 Spls (76 CF patients 46 controls) staphopains...
Background Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with barrier defects and misdirected type 2 immune response against harmless antigens. The microbiome in AD characterized by reduction microbial diversity dominance of staphylococci, including Staphylococcus epidermidis ( S. ). Objective To assess whether antigens play role AD, we screened for candidate allergens studied the T cell humoral extracellular serine protease (Esp). Methods identify allergens,...
The serine protease like (Spl) proteases of
According to the World Health Organization, blood must be screened for major transmitted infections before transfusion prevent possibility of passing an infection recipient. For accurate detection infectious disease pathogens in donors, in-vitro diagnostic medical devices (IVDs) high specificity and sensitivity should used. In mature healthcare systems, regulatory authorities authorize usage with highest performance capabilities, which are also controlled through active market oversight....
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by barrier defects and misdirected type 2 immune response against antigens. The microbiome in AD characterised reduction microbial diversity with dominance of staphylococci, including Staphylococcus epidermidis (S. epidermidis). To assess whether S. antigens play role AD, we studied the extracellular serine protease (Esp). Methods: We analyzed binding human IgG4 to proteins using immunoblotting mass...