A5004338201- Immune Cell Function and Interaction
- Childhood Cancer Survivors' Quality of Life
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Platelet Disorders and Treatments
- Cell Adhesion Molecules Research
- Cancer Risks and Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Galectins and Cancer Biology
- NF-κB Signaling Pathways
- RNA Research and Splicing
- Cholesterol and Lipid Metabolism
- Electrospun Nanofibers in Biomedical Applications
- Lipid metabolism and disorders
- 3D Printing in Biomedical Research
- Alcohol Consumption and Health Effects
- Histone Deacetylase Inhibitors Research
- Cancer Immunotherapy and Biomarkers
- Chronic Myeloid Leukemia Treatments
- Angiogenesis and VEGF in Cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
The Wallace H. Coulter Department of Biomedical Engineering
2025
Georgia Institute of Technology
2025
Emory University
2019-2024
Children's Healthcare of Atlanta
2020-2024
Aflac (United States)
2020-2024
Center for Cancer and Blood Disorders
2020
Florida Agricultural and Mechanical University
2018
Ulster Hospital
2009
South Eastern Health and Social Care Trust
2009
Abstract The incidence of obesity is rising with greater than 40% the world’s population expected to be overweight or suffering from by 2030. This alarming because increases mortality rates in patients various cancer subtypes including leukemia. survival differences between lean and are largely attributed altered drug pharmacokinetics receiving chemotherapy; whereas, direct impact an adipocyte-enriched microenvironment on cells rarely considered. Here we show that adipocyte secretome...
Vascular hypo-fibrinolysis is a historically underappreciated and understudied aspect of venous thromboembolism (VTE). This paper describes the development micro-clot dissolution assay for quantifying fibrinolytic capacity endothelial cells - key driver VTE development. enabled using aqueous two-phase systems (ATPS) to bioprint microscale fibrin clots over human umbilical vein (HUVECs). Importantly, these micro-clots are orders magnitude smaller than conventional constructs allow...
Lipotoxicity, resulting from the buildup of excess lipids in non-adipose tissues, is increasingly recognized as a major contributor to progression kidney disease, highlighting need for alternative models assess its effects on renal cells. The main aim this study was investigate usefulness Caki-1, human proximal tubule (PT) and cell carcinoma (RCC) representative line, 3D model system studying free fatty acid-induced PT lipotoxicity. Caki-1 spheroids were generated maintained ultra-low...
Aging-associated declines in innate and adaptive immune responses are well documented pose a risk for the growing aging population, which is predicted to comprise greater than 40 percent of world's population by 2050. Efforts have been made improve immunity aged populations; however, safe effective protocols accomplish this goal not universally established. chronic inflammation postulated compromise mice humans. Interleukin-37 (IL-37) potent anti-inflammatory cytokine, we present data...
Abstract Immunotherapies have revolutionized the treatment of B-cell acute lymphoblastic leukemia (B-ALL), but duration responses is still sub-optimal. We sought to identify mechanisms immune suppression in B-ALL and strategies overcome them. Plasma collected from children with measurable residual disease after induction chemotherapy showed differential cytokine expression, particularly IL-7, while single-cell RNA-sequencing revealed expression genes associated exhaustion cell subsets. also...
Obesity is a major public health crisis given its rampant growth and association with an increased risk for cancer. Interestingly, patients obesity tend to have tumor burden decreased T-cell function. It remains unclear how compromises mediated immunity. To address this question, we modeled the adipocyte niche using secretome released from adipocytes as well of stromal cells investigated these factors modulated We found that secretomes altered antigen-specific receptor (TCR) triggering...
Abstract The life expectancy of the world's elderly population (65 and older) continues to reach new milestones with older individuals currently comprising greater than 8.5% (617 million) population. This percentage is predicted approach 20% by 2050 (representing 1.6 billion people). Despite this amazing feat, many healthcare systems are not equipped handle multitude diseases that commonly manifest age, including most types cancers. As aging grows, cancer treatments continue evolve....
The world's population with obesity is reaching pandemic levels. If current trends continue, it predicted that there will be 1.5 billion people by 2030. This projection alarming due to the association of numerous diseases including cancer, recent studies demonstrating a positive acute myeloid leukemia (AML) and B cell lymphoblastic (B-ALL). Interestingly, several epidemiological suggest converse relationship may exist in patients T (T-ALL). To determine between T-ALL development, we employed...
ABSTRACT Glioblastoma (GBM) is the most common primary malignant brain tumor and resistant to current therapies. Here, using a combination of proteomic genetic approaches in both Drosophila human GBM models, we identify novel signaling effectors that act downstream EGFR PI3K pathways, which drive GBM. Our results indicate RIOK2, an atypical serine/threonine kinase, forms complex with RNA-binding protein, IMP3 (Imp ), dRIOK2/RIOK-Imp/IMP3 pathway necessary for tumorigenesis. Furthermore, our...
Abstract Background Obese pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) have inferior overall survival outcomes compared to lean patients, obese having a 2.5-fold increased risk of an adverse event and almost 4-fold greater death. Emerging data suggest that the presence factors in microenvironment may directly promote chemoresistance B-ALL cells. Objective Given increasing prevalence obesity negative impact on cancer, this study, we sought determine how adipocytes...