Upon hormone stimulation, the sst2 somatostatin receptor couples to adenylyl cyclase through G_i/o proteins and undergoes rapid endocytosis via clathrin-coated pits. In this study, we determined relationship between ability of ligands induce internalization inhibit cyclase. Immunocytochemical studies demonstrated that peptide agonists [such as somatostatin-14, cortistatin-17, octreotide, vapreotide, KE108 (Tyr0-cyclo[d-diaminobutyric acid-Arg-Phe-Phe-d-Trp-Lys-Thr-Phe]), SOM230...

The introduction of the aliphatic amines en (ethylenediamine), aep (N-(2-aminoethyl)piperazine) and tepa (tetraethylenepentamine), aromatic species 2,2'-bipy (2,2'-bipyridine) dpe (1,2-di(4-pyridyl)ethylene) as structure directing agents (SDAs) into inorganic iodoplumbates affords six hybrids, namely [(Hen)4(H2.5O)2I](PbI6) (1), Cs2n[Pb3I8(en)2]n (2), (H3tepa)n(PbI5)n (3), (H2aep)n(PbI4)n (4), (Et22,2'-bipy)n(Pb2I6)n (5) (Et2dpe)n(Pb2I6)n (6). 1 contains a discrete octahedral (PbI6)(4-)...

Precise health diagnostics and prognostics for batteries, which can improve the reliability efficiency of energy storage technologies are significant. It is still a challenge to predict diagnose state-of-health (SOH) batteries due complicated unobservable electrochemical reaction inside batteries. In this article, novel battery estimation framework based on an optimized multiple indicators (MHIs) system using fuzzy comprehensive evaluation (FCE) improved multivariate grey model (IMGM)...

Abstract Leukapheresis is a potentially life-saving therapy for children with symptomatic hyperleukocytosis. However, the standard centrifugation-based approach exposes pediatric patients to significant complications due its large extracorporeal volume, high flow rates, and considerable platelet loss. Here, we tested whether performing cell separation high-throughput microfluidic technology could alleviate these limitations. In vitro, our devices removed ~85% of leukocytes ~90% spiked...

ABSTRACT Background Tetrabromobisphenol A (TBBPA), the most widely used brominated flame retardant, has raised concerns about its potential embryonic developmental toxicity due to frequent detection in environmental samples and human body fluids, particularly umbilical cord blood. TBBPA affects zebrafish heart development, is first organ form, we aim assess whether it have on embryos. Methods This study investigated effects of environmentally relevant concentrations (1–100 nM) development...

Somatostatin (SRIF), originally described as a hypothalamic hormone that inhibits the release of growth was subsequently shown to inhibit secretion multiple pituitary hormones. Five genes encoding six different SRIF receptors (sst1,2A,2B,3,4 and 5) have been cloned mRNAs for all five are expressed in anterior pituitary. We used double immunostaining determine which cells bear sst2A sst5 receptors. Our results show these two widely distributed gland both present large percentage GH cells. In...

Regioregular poly(3-hexylthiophene) (P3HT) was employed as a hole transport material and assistant light absorber for the fabrication of CdS quantum dot-sensitized solid-state solar cell, by which power-conversion efficiency 1.42% achieved under an AM1.5 G (100 mW cm−2) condition.

Although great progress has been made in hybrid iodocuprates(i) as lighting phosphors, the effects of aromatic and aliphatic structure directing agents (SDAs) on their water stability, photoluminescence (PL) properties are still not clear. Herein, N-heterocyclic 1,2-di(4-pyridyl)ethylene (dpe), 1,8-diazabicyclo[5.4.0]undec-7-ene (dbu) N-aminoethylpiperazine (app) were selected to be SDAs construct two types via a facile situ approach. Aromatic dpe-derived cations successfully directed form...

State of charge (SOC) estimation deep-discharging Li-ion batteries under complicated working conditions at different temperatures is still challenging. Nowadays, the depth discharge (DOD) in electric vehicles (EVs) generally low, resulting insufficient use battery energy. This paper proposes a SOC method using novel partial adaptive forgetting factors recursive least square (PAFFRLS), which adjusts based on own physical properties each parameter equivalent circuit models (ECMs) to...

Liver‐intestine cadherin (CDH17) represents a novel type of within the superfamily, and is distinguished from other cadherins by its distinct structural functional features. Our previous studies had identified that increased CDH17 was significantly associated with tumor differentiation lymph node metastasis in gastric cancer. In this study, we tested hypothesis proliferation invasiveness cancer using recombinant lentivirus‐mediated miRNA targeting to both vitro vivo . We also detected...

Somatostatin receptor subtype 2A (sst2A) mediates many of the endocrine and neuronal actions somatostatin is target analogs in cancer therapy. As with G-protein-coupled receptors, agonist stimulation causes sst2A desensitization internalization, events that require phosphorylation. Furthermore, heterologous activation protein kinase C (PKC) also increases phosphorylation internalization. Here we analyzed a series mutants biochemically to identify residues carboxyl terminus were...

An LLC resonant converter would have light-load voltage regulation problems due to the effect of parasitic capacitances in a high-frequency range. In this paper, an energy feedback control method is proposed improve capacity by using synchronous rectifiers (SRs). The SR bridges are controlled ahead primary inverter deliver from load source, reducing output independent load. Then desired can be achieved even no-load conditions regulating operation time mode. gain, ripple, and efficiency...

Focal adhesion kinase (FAK) is suggested to be intimately involved in the progression of malignancies. Our previous research has demonstrated that activation cholecystokinin-2 receptor (CCK2R) by gastrin stimulates a rapid FAK pathway human colon cancer cells. The purpose this study determine role CCK2R and cancer. In study, matched tissue samples primary adjacent normal mucosa from same patient were collected 45 patients with undergoing surgical resection. expression was detected using...

Research investigating the intricacies of how self-regulated writing strategies are used in a finely focused area second language (L2) process is still lacking. This study takes mixed-methods approach to explore Chinese English as Foreign Language (EFL) learners' use when revising based on automated, peer, and teacher feedback an online EFL context. Thirty-six university learners filled three questionnaires (one per source). In addition, four followed think-aloud protocol while responding...

A thermally stable polyimide (PI-SP) was designed as a functional material for the fabrication of memory device, and its optoelectrical dual-mode studied. In an Al/PI-SP/Al can be switched on with negative or positive voltage on/off current ratios about 104. Besides, PI-SP also undergo reversibly photochromic reactions in solution solid state high fatigue resistance, which serve optical recording material. The based device exhibit electrical switching properties independently, while their...

Somatostatin analogues, which are used to treat neuroendocrine tumors, target the high levels of somatostatin receptor subtype 2 (SSTR1; alias sst2) expressed in these cancers. However, some tumors resistant and it is unknown whether defect lies sst2 activation or downstream signaling events. Because phosphorylation occurs rapidly after activation, we examined phosphorylated tumors. The was evaluated by IHC Western blot analysis with new Ra-1124 antibody specific for at Ser341/343...

Based on data mining classification technique, the neural network and decision tree algorithms were studied to build a prediction system of water inrushes through coal floors. The back propagation probabilistic compared select features algorithms. Rules floors obtained by C4.5 regression tree. inrush was built using result shows which based technique is practical workable system.

The state-of-health (SOH) is a critical parameter to determine the degradation degree of lithium-ion batteries, thus plays an important part in energy management problems electric vehicles (EVs). Due estimation dispersion health indicators, it difficult monitor conveniently and robustly SOH on-board batteries. In this paper, monitoring method for application battery system (BMS) has been presented solve issue. First all, necessity multiple indicators (MIs) demonstrated through analysis...